{"id":"https://openalex.org/W1696562329","doi":"https://doi.org/10.1089/scd.2014.0427","title":"Engineering Strategies for the Formation of Embryoid Bodies from Human Pluripotent Stem Cells","display_name":"Engineering Strategies for the Formation of Embryoid Bodies from Human Pluripotent Stem Cells","publication_year":2015,"publication_date":"2015-04-21","ids":{"openalex":"https://openalex.org/W1696562329","doi":"https://doi.org/10.1089/scd.2014.0427","mag":"1696562329","pmid":"https://pubmed.ncbi.nlm.nih.gov/25900308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4499791"},"language":"en","primary_location":{"id":"doi:10.1089/scd.2014.0427","doi":"https://doi.org/10.1089/scd.2014.0427","is_oa":false,"landing_page_url":"https://doi.org/10.1089/scd.2014.0427","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells and Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4499791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008549906","display_name":"Giuseppe Pettinato","orcid":"https://orcid.org/0000-0001-6785-6370","observed_orcids":["https://orcid.org/0000-0001-6785-6370"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Pettinato","raw_affiliation_strings":["Virginia Commonwealth University","Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103526914","display_name":"Xuejun Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xuejun Wen","raw_affiliation_strings":["Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, People's Republic of China","Virginia Commonwealth University","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]},{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100404874","display_name":"Ning Zhang","orcid":"https://orcid.org/0000-0002-6430-4236","observed_orcids":["https://orcid.org/0000-0002-6430-4236"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ning Zhang","raw_affiliation_strings":["Virginia Commonwealth University","Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100404874","https://openalex.org/A5103526914"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I184840846","https://openalex.org/I4210128175"],"apc_list":null,"apc_paid":null,"fwci":0.3233,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.25879127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"24","issue":"14","first_page":"1595","last_page":"1609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.8529999852180481},{"id":"https://openalex.org/keywords/directed-differentiation","display_name":"directed differentiation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/germ-layer-formation","display_name":"germ layer formation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.5180000066757202},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cell-dissociation","display_name":"cell dissociation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5789999961853027},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.41200000047683716},{"id":"https://openalex.org/keywords/terminal-differentiation","display_name":"terminal differentiation","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.9212011098861694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8270150423049927},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8028457164764404},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6842952966690063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5366636514663696},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.527399480342865},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4622120261192322},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4587692320346832},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34293311834335327},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21910718083381653},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12427079677581787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0523529052734375}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1089/scd.2014.0427","doi":"https://doi.org/10.1089/scd.2014.0427","is_oa":false,"landing_page_url":"https://doi.org/10.1089/scd.2014.0427","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells and Development","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3910417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4499791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4499791","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4499791","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Dev","raw_type":"Text"},{"id":"pmid:25900308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25900308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells and development","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3910417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4499791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1153853416","display_name":null,"funder_award_id":"81271369","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1914250801","display_name":null,"funder_award_id":"2012CB966300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3838804245","display_name":"CAREER: A novel space-creation concept to enhance the survival and functionality of transplanted human stem cells","funder_award_id":"0748129","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8622369499","display_name":"CAREER: Brain tissue regeneration after stroke","funder_award_id":"1055922","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W207992492","https://openalex.org/W1504504549","https://openalex.org/W1567176008","https://openalex.org/W1603508604","https://openalex.org/W1896694210","https://openalex.org/W1948275303","https://openalex.org/W1965674737","https://openalex.org/W1972662556","https://openalex.org/W1976338715","https://openalex.org/W1976628761","https://openalex.org/W1981048865","https://openalex.org/W1983707878","https://openalex.org/W1983935256","https://openalex.org/W1992426586","https://openalex.org/W1993807325","https://openalex.org/W1994665356","https://openalex.org/W1997910229","https://openalex.org/W1999459866","https://openalex.org/W2002828554","https://openalex.org/W2006557127","https://openalex.org/W2007727233","https://openalex.org/W2008048796","https://openalex.org/W2010022393","https://openalex.org/W2010353459","https://openalex.org/W2013498422","https://openalex.org/W2019131512","https://openalex.org/W2020755558","https://openalex.org/W2023315677","https://openalex.org/W2024371190","https://openalex.org/W2024457290","https://openalex.org/W2027074821","https://openalex.org/W2028634943","https://openalex.org/W2030983339","https://openalex.org/W2032105444","https://openalex.org/W2032707537","https://openalex.org/W2035741764","https://openalex.org/W2038484136","https://openalex.org/W2038723730","https://openalex.org/W2041450701","https://openalex.org/W2044880526","https://openalex.org/W2046573256","https://openalex.org/W2048722591","https://openalex.org/W2048973711","https://openalex.org/W2055151337","https://openalex.org/W2057732983","https://openalex.org/W2061166523","https://openalex.org/W2061997335","https://openalex.org/W2062118486","https://openalex.org/W2066390373","https://openalex.org/W2066960006","https://openalex.org/W2068078989","https://openalex.org/W2068959359","https://openalex.org/W2070211958","https://openalex.org/W2074431288","https://openalex.org/W2077547257","https://openalex.org/W2082003932","https://openalex.org/W2088640544","https://openalex.org/W2089562225","https://openalex.org/W2091723974","https://openalex.org/W2093764045","https://openalex.org/W2095998404","https://openalex.org/W2104269891","https://openalex.org/W2107307011","https://openalex.org/W2108080239","https://openalex.org/W2108910200","https://openalex.org/W2109850567","https://openalex.org/W2110335719","https://openalex.org/W2111786367","https://openalex.org/W2111790269","https://openalex.org/W2114879349","https://openalex.org/W2116935514","https://openalex.org/W2117036932","https://openalex.org/W2117336213","https://openalex.org/W2124066511","https://openalex.org/W2126432370","https://openalex.org/W2126816036","https://openalex.org/W2126890416","https://openalex.org/W2128268397","https://openalex.org/W2136607014","https://openalex.org/W2137843024","https://openalex.org/W2138442302","https://openalex.org/W2140395408","https://openalex.org/W2143751064","https://openalex.org/W2144010803","https://openalex.org/W2145089654","https://openalex.org/W2146776134","https://openalex.org/W2148890861","https://openalex.org/W2159004580","https://openalex.org/W2166305181","https://openalex.org/W2168967248","https://openalex.org/W2169859308","https://openalex.org/W2170941561","https://openalex.org/W2416507861","https://openalex.org/W2472555719","https://openalex.org/W4211042291"],"related_works":["https://openalex.org/W174493436","https://openalex.org/W127312914","https://openalex.org/W2514414406","https://openalex.org/W2117036932","https://openalex.org/W1567176008","https://openalex.org/W7139653537","https://openalex.org/W7098350796","https://openalex.org/W1965674737","https://openalex.org/W7002490978","https://openalex.org/W4245283060"],"abstract_inverted_index":{"Human":[0],"pluripotent":[1],"stem":[2],"cells":[3,202],"(hPSCs)":[4],"are":[5,106,226,256],"powerful":[6],"tools":[7],"for":[8,211],"regenerative":[9],"therapy":[10],"and":[11,100,110,126,133,216,235,242,253],"studying":[12],"human":[13,195],"developmental":[14,70],"biology,":[15],"attributing":[16],"to":[17,20,38,48,55,66,88,143,161,165,184,192],"their":[18,40],"ability":[19],"differentiate":[21],"into":[22,117,177],"many":[23,83],"functional":[24],"cell":[25,51,76,119,172,185],"types":[26,77,120],"in":[27,33,42,58,64,108,121,136,139,144,151,245,250],"the":[28,50,61,68,128,166,175,208,217,220,224,231,238,243],"body.":[29],"The":[30],"main":[31],"challenge":[32],"realizing":[34],"hPSC":[35,115],"potential":[36],"is":[37,54],"guide":[39],"differentiation":[41,52,116,222,255],"a":[43,90,122,140],"well-controlled":[44],"manner.":[45],"One":[46],"way":[47],"control":[49],"process":[53,241],"recapitulate":[56],"during":[57,174],"vitro":[59],"culture":[60],"key":[62],"events":[63],"embryogenesis":[65],"obtain":[67,89],"three":[69],"germ":[71],"layers":[72],"from":[73,97,155,199,214],"which":[74],"all":[75],"arise.":[78],"To":[79],"achieve":[80],"this":[81,206],"goal,":[82],"techniques":[84],"have":[85,190],"been":[86],"tested":[87],"cellular":[91],"cluster,":[92],"an":[93],"embryoid":[94,196],"body":[95],"(EB),":[96],"both":[98],"mouse":[99,156],"hPSCs.":[101,204],"Generation":[102],"of":[103,130,168,203,223,237],"EBs":[104],"that":[105],"homogeneous":[107],"size":[109],"shape":[111],"would":[112],"allow":[113],"directed":[114,254],"desired":[118],"more":[123],"synchronous":[124],"manner":[125],"define":[127],"roles":[129],"cell-cell":[131],"interaction":[132],"spatial":[134],"organization":[135],"lineage":[137],"specification":[138],"setting":[141],"similar":[142],"vivo":[145],"embryonic":[146],"development.":[147],"However,":[148],"previous":[149],"success":[150],"uniform":[152,194],"EB":[153],"formation":[154,240],"PSCs":[157],"cannot":[158],"be":[159],"extrapolated":[160],"hPSCs":[162,181,215],"possibly":[163],"due":[164],"destabilization":[167],"adherens":[169],"junctions":[170],"on":[171,219,230],"surfaces":[173],"dissociation":[176],"single":[178,201],"cells,":[179],"making":[180],"extremely":[182],"vulnerable":[183],"death.":[186],"Recently,":[187],"new":[188],"advances":[189],"emerged":[191],"form":[193],"bodies":[197],"(hEBs)":[198],"dissociated":[200],"In":[205],"review,":[207],"existing":[209],"methods":[210],"hEB":[212,239,251],"production":[213,252],"results":[218],"downstream":[221],"hEBs":[225],"described":[227],"with":[228],"emphases":[229],"efficiency,":[232],"homogeneity,":[233],"scalability,":[234],"reproducibility":[236],"yield":[244],"terminal":[246],"differentiation.":[247],"New":[248],"trends":[249],"discussed.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}