{"id":"https://openalex.org/W169645331","doi":null,"title":"The endogenous cardiac cannabinoid system: a new protective mechanism against myocardial ischemia.","display_name":"The endogenous cardiac cannabinoid system: a new protective mechanism against myocardial ischemia.","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W169645331","mag":"169645331","pmid":"https://pubmed.ncbi.nlm.nih.gov/16618028"},"language":"en","primary_location":{"id":"pmid:16618028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives des maladies du coeur et des vaisseaux","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000012041","display_name":"Daniel Lamontagne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D Lamontagne","raw_affiliation_strings":["Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, QC, Canada. daniel.lamontagne@umontreal.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, QC, Canada. daniel.lamontagne@umontreal.ca","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075075585","display_name":"Philippe L\u00e9picier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L\u00e9picier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091513065","display_name":"Caroline Lagneux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Lagneux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053353268","display_name":"Jean\u2010Fran\u00e7ois Bouchard","orcid":"https://orcid.org/0000-0001-9622-6239","observed_orcids":["https://orcid.org/0000-0001-9622-6239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Bouchard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4299,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.91963348,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"99","issue":"3","first_page":"242","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":0.824999988079071},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anandamide","display_name":"anandamide","score":0.8460000157356262},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.847000002861023},{"id":"https://openalex.org/keywords/synthetic-cannabinoids","display_name":"synthetic cannabinoids","score":0.640999972820282},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7250000238418579},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.7950000166893005},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.9113745093345642},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.8378568887710571},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.7430866360664368},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.7300959825515747},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.658424973487854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6085633635520935},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.5865422487258911},{"id":"https://openalex.org/C2780433416","wikidata":"https://www.wikidata.org/wiki/Q5032579","display_name":"Cannabinoid receptor antagonist","level":5,"score":0.5738451480865479},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5533292293548584},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.55259108543396},{"id":"https://openalex.org/C158026453","wikidata":"https://www.wikidata.org/wiki/Q18026372","display_name":"GPR18","level":5,"score":0.4781028628349304},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.36558961868286133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3113415837287903}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063387","descriptor_name":"Cannabinoid Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16618028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives des maladies du coeur et des vaisseaux","raw_type":"Journal Article"},{"id":"mag:169645331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W101692089","https://openalex.org/W1581998318","https://openalex.org/W1593645241","https://openalex.org/W1651476949","https://openalex.org/W1832918544","https://openalex.org/W1918234784","https://openalex.org/W1963665235","https://openalex.org/W1968366571","https://openalex.org/W1969453374","https://openalex.org/W1972766090","https://openalex.org/W1973196998","https://openalex.org/W1974642601","https://openalex.org/W1980923223","https://openalex.org/W1987096508","https://openalex.org/W1989073099","https://openalex.org/W1997357791","https://openalex.org/W2003594380","https://openalex.org/W2015614945","https://openalex.org/W2030142394","https://openalex.org/W2030159344","https://openalex.org/W2036334874","https://openalex.org/W2038882750","https://openalex.org/W2053635170","https://openalex.org/W2056188558","https://openalex.org/W2056873485","https://openalex.org/W2056993290","https://openalex.org/W2057468498","https://openalex.org/W2064819108","https://openalex.org/W2065648126","https://openalex.org/W2066626783","https://openalex.org/W2067532534","https://openalex.org/W2068129165","https://openalex.org/W2075894678","https://openalex.org/W2084691167","https://openalex.org/W2089640223","https://openalex.org/W2094435043","https://openalex.org/W2096529235","https://openalex.org/W2103297906","https://openalex.org/W2106833965","https://openalex.org/W2114103705","https://openalex.org/W2116169298","https://openalex.org/W2120141818","https://openalex.org/W2125376647","https://openalex.org/W2126766019","https://openalex.org/W2136399145","https://openalex.org/W2138318413","https://openalex.org/W2150053033","https://openalex.org/W2158771670","https://openalex.org/W2248504579","https://openalex.org/W4406382335"],"related_works":["https://openalex.org/W2422574619","https://openalex.org/W2036334874","https://openalex.org/W1982485199","https://openalex.org/W1976426436","https://openalex.org/W2089640223","https://openalex.org/W1611613250","https://openalex.org/W2334869634","https://openalex.org/W1982638440","https://openalex.org/W1983876972","https://openalex.org/W2066807462"],"abstract_inverted_index":{"The":[0,83,110,159],"pharmacological":[1],"(and":[2],"recreational)":[3],"effects":[4,34,154],"of":[5,23,35,43,85,136,161,194,202],"cannabis":[6],"have":[7],"been":[8,168],"known":[9],"for":[10,49],"centuries.":[11],"However,":[12],"it":[13],"is":[14,94,101,131],"only":[15],"recently":[16],"that":[17,46],"one":[18],"has":[19,167],"identified":[20],"two":[21,67],"subtypes":[22],"G-protein-coupled":[24],"receptors,":[25],"namely":[26],"CB1":[27,79,87,148],"and":[28,37,54,62,76,88,141,175],"CB2-receptors,":[29,150,195],"which":[30],"mediate":[31],"the":[32,41,65,91,134,144,187],"numerous":[33],"delta9-tetrahydrocannabinol":[36],"other":[38],"cannabinoids.":[39],"Logically,":[40],"existence":[42],"cannabinoid-receptors":[44],"implies":[45],"endogenous":[47,97,188],"ligands":[48],"these":[50],"receptors":[51],"(endocannabinoids)":[52],"exist":[53],"exert":[55,151],"a":[56,137],"physiological":[57],"role.":[58],"Hence,":[59],"arachidonoylethanolamide":[60],"(anandamide)":[61],"sn-2":[63],"arachidonoylglycerol,":[64],"first":[66],"endocannabinoids":[68],"identified,":[69],"are":[70],"formed":[71],"from":[72],"plasma":[73],"membrane":[74],"phospholipids":[75],"act":[77],"as":[78],"and/or":[80],"CB2":[81],"agonists.":[82],"presence":[84,135],"both":[86],"CB2-receptors":[89],"in":[90,103,112,119,133,155,170,172],"rat":[92,156],"heart":[93],"noteworthy.":[95],"This":[96,177],"cardiac":[98,189],"cannabinoid":[99,190],"system":[100],"involved":[102],"several":[104],"phenomena":[105],"associated":[106],"with":[107],"cardioprotective":[108,153],"effects.":[109],"reduction":[111],"infarct":[113,165],"size":[114,166],"following":[115],"myocardial":[116,205],"ischemia,":[117],"observed":[118],"rats":[120],"exposed":[121],"to":[122,163,181,197],"either":[123,147],"LPS":[124],"or":[125,149],"heat":[126],"stress":[127],"24":[128],"hours":[129],"before,":[130],"abolished":[132],"CB2-receptor":[138],"antagonist.":[139],"Endocannabinoids":[140],"synthetic":[142],"cannabinoids,":[143],"latter":[145,178],"through":[146,184,192],"direct":[152],"isolated":[157],"hearts.":[158],"ability":[160],"cannabinoids":[162],"reduce":[164],"confirmed":[169],"vivo":[171],"anesthetized":[173],"mice":[174],"rats.":[176],"effect":[179],"appears":[180,196],"be":[182,198],"mediated":[183],"CB2-receptors.":[185],"Thus,":[186],"system,":[191],"activation":[193],"an":[199],"important":[200],"mechanism":[201],"protection":[203],"against":[204],"ischemia.":[206]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
