{"id":"https://openalex.org/W169596199","doi":null,"title":"[Liraglutide (Victoza): human glucagon-like peptide-1 used in once daily injection for the treatment of type 2 diabetes].","display_name":"[Liraglutide (Victoza): human glucagon-like peptide-1 used in once daily injection for the treatment of type 2 diabetes].","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W169596199","mag":"169596199","pmid":"https://pubmed.ncbi.nlm.nih.gov/20857706"},"language":"fr","primary_location":{"id":"pmid:20857706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20857706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue medicale de Liege","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/handle/2268/79460","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039563874","display_name":"Andr\u00e9 Jacques Scheen","orcid":"https://orcid.org/0000-0001-9743-4371","observed_orcids":["https://orcid.org/0000-0001-9743-4371"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"A J Scheen","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge, D\u00e9partement de M\u00e9decine, Belgique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge, D\u00e9partement de M\u00e9decine, Belgique","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111609726","display_name":"Luc F. Van Gaal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L F Van Gaal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5858,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.69887307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"65","issue":"7-8","first_page":"464","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":1.0},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9319999814033508},{"id":"https://openalex.org/keywords/incretin-mimetics","display_name":"incretin mimetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8029999732971191},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7179999947547913},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.7269999980926514},{"id":"https://openalex.org/keywords/subcutaneous-injection","display_name":"subcutaneous injection","score":0.8140000104904175},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.5580000281333923},{"id":"https://openalex.org/keywords/belgium","display_name":"Belgium","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.914206326007843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7829525470733643},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6958032846450806},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5976250767707825},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5435530543327332},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.5134307146072388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5094276070594788},{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.4585729241371155},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4053717255592346},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.39065858721733093},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3355207145214081},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.06510815024375916}],"mesh":[{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20857706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20857706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue medicale de Liege","raw_type":"English Abstract"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/79460","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/79460","pdf_url":"https://orbi.uliege.be/handle/2268/79460","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revue M\u00e9dicale de Li\u00e8ge, 65 (7-8), 464-70 (2010)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/79460","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/79460","pdf_url":"https://orbi.uliege.be/handle/2268/79460","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revue M\u00e9dicale de Li\u00e8ge, 65 (7-8), 464-70 (2010)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W169596199.pdf","grobid_xml":"https://content.openalex.org/works/W169596199.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W31342138","https://openalex.org/W34054004","https://openalex.org/W1504374936","https://openalex.org/W2007217090","https://openalex.org/W2033673890","https://openalex.org/W2037791305","https://openalex.org/W2061549173","https://openalex.org/W2070762414","https://openalex.org/W2071835038","https://openalex.org/W2098459806","https://openalex.org/W2113367996","https://openalex.org/W2118762421","https://openalex.org/W2134806962","https://openalex.org/W2135940808","https://openalex.org/W2137352234","https://openalex.org/W2137830546","https://openalex.org/W2138290933","https://openalex.org/W2149762820","https://openalex.org/W2152835319","https://openalex.org/W2152969995","https://openalex.org/W2159205789","https://openalex.org/W2160001758","https://openalex.org/W2161671847","https://openalex.org/W2170606300","https://openalex.org/W2509949587"],"related_works":["https://openalex.org/W2037791305","https://openalex.org/W4237830553","https://openalex.org/W4298296083","https://openalex.org/W1994262439","https://openalex.org/W2410107832","https://openalex.org/W2055103647","https://openalex.org/W4234847699","https://openalex.org/W4214941009","https://openalex.org/W2340184067","https://openalex.org/W2476906272"],"abstract_inverted_index":{"Liraglutide":[0],"(Victoza)":[1],"is":[2,20,133,163,169],"a":[3,48,53,88,93,151,160,173],"peptide":[4],"produced":[5],"by":[6,78],"DNA":[7],"recombinant":[8],"technology,":[9],"which":[10],"presents":[11],"97%":[12],"homology":[13],"with":[14,70,123,128,143,150,179],"human":[15],"glucagon-like":[16],"peptide-1":[17],"(GLP-1)":[18],"but":[19,112],"resistant":[21],"to":[22,182,193,205],"dipeptidylpeptidase-4,":[23],"the":[24,28,33,107,115,118,187],"enzyme":[25],"that":[26],"degrades":[27],"natural":[29],"hormone.":[30],"It":[31,85],"actives":[32],"GLP-1":[34],"receptor":[35],"and":[36,64,92,120,168,186,203],"exerts":[37],"an":[38],"incretin":[39],"mimetic":[40],"effect":[41,56],"during":[42,106],"at":[43,79,199],"least":[44,80,200],"24":[45],"hours":[46],"after":[47,198],"single":[49],"subcutaneous":[50],"injection.":[51],"Besides":[52],"glucose-dependent":[54],"stimulatory":[55],"of":[57,110,117,153],"insulin":[58],"secretion,":[59],"liraglutide":[60,132],"inhibits":[61],"glucagon":[62],"secretion":[63],"retards":[65],"gastric":[66],"emptying.":[67],"In":[68],"patients":[69,142],"type":[71,144],"2":[72,145],"diabetes,":[73],"it":[74],"reduces":[75],"glycated":[76],"haemoglobin":[77],"1%,":[81],"without":[82],"inducing":[83],"hypoglycaemia.":[84],"also":[86],"induces":[87],"moderate":[89],"weight":[90],"loss":[91],"mild":[94],"reduction":[95],"in":[96,126,136,141,165],"blood":[97],"pressure.":[98],"Gastrointestinal":[99],"adverse":[100],"events":[101],"(nausea,":[102],"vomiting)":[103],"may":[104],"occur":[105],"initial":[108],"phase":[109],"treatment,":[111],"rarely":[113],"impose":[114],"interruption":[116],"medication":[119],"usually":[121],"diminish":[122],"time.Although":[124],"indicated":[125],"combination":[127,152],"other":[129],"glucose-lowering":[130],"agents,":[131],"currently":[134],"reimbursed":[135],"Belgium":[137],"only":[138],"if":[139,210],"administered":[140],"diabetes":[146],"not":[147],"sufficiently":[148],"controlled":[149],"metformin":[154,158],"plus":[155,159],"sulfonylurea":[156],"or":[157],"thiazolidinedione.":[161],"Victoza":[162],"presented":[164],"prefilled":[166],"pens":[167],"injected":[170],"subcutaneously":[171],"once":[172],"day.":[174],"Treatment":[175],"will":[176,190],"be":[177,191],"initiated":[178],"0.6":[180],"mg":[181,195,207],"improve":[183],"digestive":[184],"tolerance":[185],"daily":[188],"dose":[189],"increased":[192],"1.2":[194],"(usual":[196],"dose)":[197,209],"one":[201],"week,":[202],"up":[204],"1.8":[206],"(maximal":[208],"necessary.":[211]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}