{"id":"https://openalex.org/W169590802","doi":null,"title":"Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics.","display_name":"Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics.","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W169590802","mag":"169590802","pmid":"https://pubmed.ncbi.nlm.nih.gov/7581127"},"language":"en","primary_location":{"id":"pmid:7581127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7581127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone marrow transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111377980","display_name":"John T. Slattery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J T Slattery","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103391116","display_name":"Jean E. Sanders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Sanders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110892853","display_name":"C. Dean Buckner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C D Buckner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006825195","display_name":"Randy L. Schaffer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Schaffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K W Lambert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K W Lambert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F P Langer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F P Langer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060783496","display_name":"Claudio Anasetti","orcid":"https://orcid.org/0000-0002-0119-0622","observed_orcids":["https://orcid.org/0000-0002-0119-0622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Anasetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113514827","display_name":"William Bensinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W I Bensinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108076832","display_name":"Lloyd D. Fisher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L D Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056405520","display_name":"Frederick R. Appelbaum","orcid":"https://orcid.org/0000-0002-1839-5069","observed_orcids":["https://orcid.org/0000-0002-1839-5069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F R Appelbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4727,"has_fulltext":false,"cited_by_count":343,"citation_normalized_percentile":{"value":0.88834655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"31","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/busulfan","display_name":"busulfan","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.746999979019165},{"id":"https://openalex.org/keywords/steady-state-plasma-concentration","display_name":"steady-state plasma concentration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8420000076293945},{"id":"https://openalex.org/keywords/regimen-related-toxicity","display_name":"regimen-related toxicity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/autologous-transplantation","display_name":"autologous transplantation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hla-matched-donor","display_name":"HLA-matched donor","score":0.597000002861023},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2780611847","wikidata":"https://www.wikidata.org/wiki/Q348922","display_name":"Busulfan","level":4,"score":0.9787087440490723},{"id":"https://openalex.org/C2777501473","wikidata":"https://www.wikidata.org/wiki/Q1796666","display_name":"Body surface area","level":2,"score":0.6997986435890198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6736021041870117},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5578450560569763},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5144572257995605},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5048795342445374},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.502589225769043},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4736386835575104},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.4413513243198395},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.43685805797576904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.395801305770874},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3820153772830963},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3490567207336426},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.301776647567749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15173274278640747},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7581127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7581127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone marrow transplantation","raw_type":"Journal Article"},{"id":"mag:169590802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7581127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3034927040","display_name":"AUTOLOGOUS MORROW TRANSPLANTATION","funder_award_id":"P01CA047748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4454968240","display_name":"IMMUNOLOGIC STUDIES IN STEM CELL GRAFTS FOR MALIGNANCIES","funder_award_id":"P01CA018221","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000906164","display_name":"Adult Leukemia Research Center","funder_award_id":"P01CA018029","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2334769895","https://openalex.org/W1997472326","https://openalex.org/W2073950086","https://openalex.org/W2084783894","https://openalex.org/W2581431531","https://openalex.org/W1976623989","https://openalex.org/W2317796628","https://openalex.org/W2332514522","https://openalex.org/W2028418551","https://openalex.org/W2004720617"],"abstract_inverted_index":{"We":[0,214],"have":[1,21],"determined":[2],"the":[3,23,130,160,166,171,197,233,241],"relationships":[4],"between":[5],"busulfan":[6,26,38,79,94,135,217,236],"average":[7,91,136],"concentration":[8,80,92,137,218],"at":[9,95,98,138],"steady-state":[10,96,139],"and":[11,16,20,31,190,228,231,250],"(1)":[12],"rejection":[13,106,118],"of":[14,25,37,44,85,93,97,107,119,129,163,169,173,199,225,235,243],"graft,":[15,110],"(2)":[17],"regimen-related":[18,229],"toxicity,":[19,230],"evaluated":[22],"dependence":[24],"clearance/F":[27,144,176,183,204],"on":[28],"body":[29,148,151,194,212],"size":[30],"age.":[32],"Patients":[33],"received":[34],"16-30":[35],"mg/kg":[36,50],"followed":[39],"by":[40],"cyclophosphamide":[41],"in":[42,54,63,175,186,219],"doses":[43],"120,":[45],"150,":[46],"174,":[47],"or":[48,51,59,122,153,210],"200":[49,100],"8":[52],"g/m2":[53],"preparation":[55],"for":[56,177,193,203,247],"autologous,":[57],"syngeneic":[58],"allogeneic":[60],"grafts":[61],"varying":[62],"compatibility":[64],"from":[65],"HLA-matched":[66,123],"siblings":[67],"to":[68,104,116,147,208],"HLA-partially-matched":[69,120],"unrelated":[70,124],"donors.":[71],"In":[72],"a":[73,82,108,244],"multivariate":[74],"Cox":[75],"time-to-rejection":[76],"analysis,":[77],"only":[78],"remained":[81],"significant":[83],"determinant":[84,224],"rejection,":[86],"P":[87],"=":[88,141],"0.0154.":[89],"An":[90],"least":[99],"ng/ml":[101,113],"was":[102,114,180,184,201],"needed":[103,115],"avoid":[105,117],"matched-sibling":[109],"while":[111],"600":[112],"related":[121],"donor":[125],"grafts.":[126],"The":[127],"toxicity":[128],"cytoreductive":[131],"regimen":[132],"correlated":[133],"with":[134,157,238],"(rs":[140],"0.717).":[142],"Busulfan":[143],"expressed":[145,185,206],"relative":[146,207],"weight,":[149],"ideal":[150,211],"weight":[152],"surface":[154,195],"area":[155],"declined":[156],"age":[158,239],"during":[159],"first":[161],"decade":[162],"life.":[164],"Over":[165],"entire":[167],"span":[168],"age,":[170],"coefficient":[172,198],"variation":[174,200],"all":[178,248],"ages":[179,249],"similar":[181],"when":[182,191,205],"absolute":[187],"terms":[188],"(ml/min)":[189],"adjusted":[192],"area;":[196],"greater":[202],"total":[209],"weight.":[213],"conclude":[215],"that":[216,232],"plasma":[220],"is":[221],"an":[222],"important":[223],"graft":[226],"survival":[227],"variability":[234],"pharmacokinetics":[237],"precludes":[240],"use":[242],"fixed":[245],"dose":[246],"indications.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}