{"id":"https://openalex.org/W169560053","doi":null,"title":"Adjuvant Effect of Chaperone-Rich Cell Lysate: The Effects of CRCL on the Activation of Immune Cells","display_name":"Adjuvant Effect of Chaperone-Rich Cell Lysate: The Effects of CRCL on the Activation of Immune Cells","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W169560053","mag":"169560053"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/195380","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035262856","display_name":"Jessica Cantrell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jessica Cantrell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035262856"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.6830000281333923},{"id":"https://openalex.org/keywords/adjuvant-effect","display_name":"adjuvant effect","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.6380000114440918},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.753000020980835},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.6320000290870667},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.8283063769340515},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.795231819152832},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6883792281150818},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6394192576408386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5228450894355774},{"id":"https://openalex.org/C3020653616","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cell mediated immunity","level":4,"score":0.4547703266143799},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4373360276222229},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42628055810928345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3455996513366699},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3220983147621155},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3205331563949585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3136078119277954},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.28023478388786316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2204107642173767},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09885790944099426}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/195380","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:169560053","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/195380","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W2693788","https://openalex.org/W78655967","https://openalex.org/W333385333","https://openalex.org/W1483162601","https://openalex.org/W1491508553","https://openalex.org/W1507525689","https://openalex.org/W1512806851","https://openalex.org/W1515599953","https://openalex.org/W1518351006","https://openalex.org/W1518851630","https://openalex.org/W1529036199","https://openalex.org/W1530044612","https://openalex.org/W1555650656","https://openalex.org/W1557404445","https://openalex.org/W1558109280","https://openalex.org/W1567420244","https://openalex.org/W1569070916","https://openalex.org/W1585754595","https://openalex.org/W1589943699","https://openalex.org/W1604363681","https://openalex.org/W1661544713","https://openalex.org/W1679259039","https://openalex.org/W1834041853","https://openalex.org/W1844093494","https://openalex.org/W1898102248","https://openalex.org/W1903082827","https://openalex.org/W1930746622","https://openalex.org/W1948343798","https://openalex.org/W1959729040","https://openalex.org/W1962132325","https://openalex.org/W1966073503","https://openalex.org/W1968846402","https://openalex.org/W1969534996","https://openalex.org/W1978926805","https://openalex.org/W1980785340","https://openalex.org/W1987589866","https://openalex.org/W1990854674","https://openalex.org/W1992245975","https://openalex.org/W1997390346","https://openalex.org/W2001015172","https://openalex.org/W2002704444","https://openalex.org/W2002726823","https://openalex.org/W2004708987","https://openalex.org/W2008267385","https://openalex.org/W2012588209","https://openalex.org/W2013707917","https://openalex.org/W2019060341","https://openalex.org/W2019505133","https://openalex.org/W2022369366","https://openalex.org/W2024786578","https://openalex.org/W2026426963","https://openalex.org/W2029157767","https://openalex.org/W2029173765","https://openalex.org/W2031000782","https://openalex.org/W2031745114","https://openalex.org/W2033328196","https://openalex.org/W2037882509","https://openalex.org/W2038381158","https://openalex.org/W2044269184","https://openalex.org/W2047003662","https://openalex.org/W2051793369","https://openalex.org/W2053925603","https://openalex.org/W2054247098","https://openalex.org/W2054626405","https://openalex.org/W2055730705","https://openalex.org/W2061561495","https://openalex.org/W2062289724","https://openalex.org/W2064061480","https://openalex.org/W2064626913","https://openalex.org/W2066641743","https://openalex.org/W2069015517","https://openalex.org/W2073694191","https://openalex.org/W2077273880","https://openalex.org/W2079439641","https://openalex.org/W2079684065","https://openalex.org/W2083682196","https://openalex.org/W2085307511","https://openalex.org/W2090640877","https://openalex.org/W2094605832","https://openalex.org/W2097811455","https://openalex.org/W2098394317","https://openalex.org/W2098958083","https://openalex.org/W2099735866","https://openalex.org/W2106511557","https://openalex.org/W2107993295","https://openalex.org/W2110393497","https://openalex.org/W2110753254","https://openalex.org/W2110836981","https://openalex.org/W2111220263","https://openalex.org/W2113030185","https://openalex.org/W2113769407","https://openalex.org/W2116013738","https://openalex.org/W2123311867","https://openalex.org/W2124993705","https://openalex.org/W2129319296","https://openalex.org/W2130282385","https://openalex.org/W2130486201","https://openalex.org/W2132207502","https://openalex.org/W2135923075","https://openalex.org/W2137560059","https://openalex.org/W2138163780","https://openalex.org/W2139226941","https://openalex.org/W2141785549","https://openalex.org/W2145736817","https://openalex.org/W2146934919","https://openalex.org/W2148573587","https://openalex.org/W2148911309","https://openalex.org/W2149723200","https://openalex.org/W2149864243","https://openalex.org/W2151151763","https://openalex.org/W2154224978","https://openalex.org/W2155906523","https://openalex.org/W2160117150","https://openalex.org/W2161545566","https://openalex.org/W2162819001","https://openalex.org/W2163175900","https://openalex.org/W2163443542","https://openalex.org/W2164987676","https://openalex.org/W2165113979","https://openalex.org/W2166732256","https://openalex.org/W2166798619","https://openalex.org/W2166982025","https://openalex.org/W2167523219","https://openalex.org/W2168985658","https://openalex.org/W2169233545","https://openalex.org/W2171446213","https://openalex.org/W2387951605","https://openalex.org/W2564152524"],"related_works":["https://openalex.org/W2029770349","https://openalex.org/W2101136647","https://openalex.org/W2061561495","https://openalex.org/W2010874837","https://openalex.org/W2693788","https://openalex.org/W764125587","https://openalex.org/W2053925603","https://openalex.org/W2082903790","https://openalex.org/W2026377720","https://openalex.org/W2079684065"],"abstract_inverted_index":{"Cancer":[0],"immunotherapy":[1],"aims":[2],"to":[3,11,21,29,77,115,140,148,166,194,333],"use":[4],"and":[5,24,93,96,152,210,224,233,245,254,264,267,291,295,329],"manipulate":[6],"the":[7,102,149,167,183,196,202,216,270,282,287,296,299,318],"host\u2019s":[8],"immune":[9,26,99,150],"system":[10,151],"fight":[12],"against":[13,81,101],"cancer.":[14],"The":[15,130,189],"objective":[16],"of":[17,46,66,85,133,145,169,185,219,222,252,272,277,285,289,298,312],"this":[18,268],"strategy":[19],"is":[20,314],"induce":[22],"specific":[23,47,94],"persistent":[25],"responses":[27,100],"leading":[28],"tumor":[30,72,103,128,146],"eradication.":[31],"Heat":[32],"shock":[33],"proteins":[34],"(HSP)":[35],"purified":[36,125],"from":[37,71,104,136,173],"cancer":[38],"tissues":[39],"have":[40,54],"been":[41,108,113],"identified":[42],"as":[43],"unique":[44],"mediators":[45],"anti-tumor":[48],"immunity.":[49],"In":[50],"our":[51],"laboratory,":[52],"we":[53],"developed":[55],"an":[56,78],"original":[57],"vaccine,":[58],"termed":[59],"CRCL":[60,74,111,134,204,213,230,241,250,280,309],"(Chaperone-Rich":[61],"Cell":[62],"Lysate)":[63],"that":[64],"consists":[65],"multiple":[67],"HSP":[68,126],"complexes":[69],"enriched":[70],"lysates.":[73,129],"immunization":[75],"leads":[76],"efficient":[79,118],"protection":[80],"a":[82,90,142],"wide":[83,143],"variety":[84,144],"murine":[86],"cancers":[87],"by":[88,153,201,235,306,317],"inducing":[89,236],"strong,":[91],"long-lasting,":[92],"T":[95,161],"NK-cell":[97],"dependent":[98],"which":[105],"it":[106],"has":[107,112],"generated.":[109],"Tumor-derived":[110],"shown":[114],"be":[116],"more":[117],"in":[119,206,248,257,262,265,344],"triggering":[120],"DC":[121,223,232,253,290,313,328],"activation":[122,251,261,271,297,311],"than":[123],"individual":[124],"or":[127],"immunostimulatory":[131],"effects":[132,218],"arise":[135],"its":[137],"superior":[138],"ability":[139],"provide":[141],"antigens":[147],"providing":[154],"potent":[155],"adjuvant":[156],"effects.":[157],"However,":[158],"CD4\u207aCD25\u207a":[159],"regulatory":[160],"lymphocytes":[162],"(Treg)":[163],"critically":[164],"contribute":[165],"mechanisms":[168],"cancer-induced":[170],"suppression.":[171],"Data":[172],"independent":[174],"groups":[175],"including":[176],"ours":[177],"suggests":[178],"they":[179],"may":[180,214],"also":[181],"restrain":[182],"function":[184],"antigen":[186,207],"presenting":[187,208],"cells.":[188],"current":[190],"study":[191],"was":[192],"designed":[193],"elucidate":[195],"molecular":[197],"signaling":[198,274],"events":[199],"triggered":[200],"tumor-derived":[203,326],"vaccine":[205],"cells":[209],"evaluate":[211],"whether":[212],"overcome":[215],"inhibitory":[217],"Treg":[220,334],"modulation":[221],"macrophage":[225,292],"activation.":[226],"Our":[227,323],"results":[228,256,324,337],"indicate":[229,325],"activates":[231],"macrophages":[234,255,330],"proinflammatory":[237],"cytokine":[238,320],"chemokine":[239],"secretion.":[240],"induces":[242],"iNOS":[243],"expression":[244],"NO":[246],"production":[247,288],"macrophages.":[249],"transcription":[258,300],"factor":[259,301],"NF-\u03baB":[260,302],"vitro":[263],"vivo,":[266],"includes":[269],"additional":[273],"molecules":[275],"upstream":[276],"NF-\u03baB.":[278],"Following":[279],"treatment":[281],"phenotypic":[283],"maturation":[284],"DC,":[286],"pro-inflammatory":[293],"cytokines,":[294],"are":[303,331,338],"not":[304,315],"affected":[305],"Treg.":[307],"Additionally,":[308],"induced":[310],"diminished":[316],"immunosuppressive":[319],"TGF-\u03b2":[321],"1.":[322],"CRCL-treated":[327],"refractory":[332],"inhibition.":[335],"These":[336],"important":[339],"for":[340],"advancing":[341],"CRCL-based":[342],"vaccines":[343],"Phase":[345],"I":[346],"clinical":[347],"trials.":[348]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
