{"id":"https://openalex.org/W169385167","doi":null,"title":"Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome.","display_name":"Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome.","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W169385167","mag":"169385167","pmid":"https://pubmed.ncbi.nlm.nih.gov/9322139"},"language":"en","primary_location":{"id":"pmid:9322139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9322139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090459826","display_name":"Steven Kesten","orcid":"https://orcid.org/0000-0002-5522-7910","observed_orcids":["https://orcid.org/0000-0002-5522-7910"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Kesten","raw_affiliation_strings":["Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052687488","display_name":"C. Chaparro","orcid":"https://orcid.org/0000-0003-0119-5412","observed_orcids":["https://orcid.org/0000-0003-0119-5412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Chaparro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028576135","display_name":"M Scavuzzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Scavuzzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089402006","display_name":"Carlos Guti\u00e9rrez","orcid":"https://orcid.org/0000-0003-0764-7408","observed_orcids":["https://orcid.org/0000-0003-0764-7408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Gutierrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.2446,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.97242089,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"16","issue":"9","first_page":"905","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.996999979019165},{"id":"https://openalex.org/keywords/bronchiolitis-obliterans-syndrome","display_name":"bronchiolitis obliterans syndrome","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chronic-lung-allograft-rejection","display_name":"chronic lung allograft rejection","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fev1-decline","display_name":"FEV1 decline","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.7720000147819519},{"id":"https://openalex.org/keywords/immunosuppressant-toxicity","display_name":"immunosuppressive drug toxicity","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9210889339447021},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.9131337404251099},{"id":"https://openalex.org/C2776739411","wikidata":"https://www.wikidata.org/wiki/Q614750","display_name":"Bronchiolitis obliterans","level":4,"score":0.8873754739761353},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.6013644933700562},{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.5790229439735413},{"id":"https://openalex.org/C55520419","wikidata":"https://www.wikidata.org/wiki/Q660995","display_name":"Vital capacity","level":5,"score":0.5114401578903198},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.48780205845832825},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.486261248588562},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4820786118507385},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4778423011302948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4774106740951538},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4188287556171417},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.1979910135269165},{"id":"https://openalex.org/C165637977","wikidata":"https://www.wikidata.org/wiki/Q11067835","display_name":"Diffusing capacity","level":4,"score":0.14812925457954407},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.14026561379432678}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001989","descriptor_name":"Bronchiolitis Obliterans","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001989","descriptor_name":"Bronchiolitis Obliterans","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9322139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9322139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","raw_type":"Journal Article"},{"id":"mag:169385167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9322139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059125624","https://openalex.org/W2077127271","https://openalex.org/W1973588187","https://openalex.org/W2058851228","https://openalex.org/W2065134162","https://openalex.org/W2165001333","https://openalex.org/W1998379866","https://openalex.org/W2052647445","https://openalex.org/W2166218591","https://openalex.org/W2006640227"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"lung":[2,10,21,44,76,240],"allograft":[3],"rejection":[4],"manifested":[5],"by":[6,72],"sustained":[7,73,245],"declines":[8],"in":[9,75,88,122,152,160,164,182,201,218,222,234,239],"function":[11,77,241],"is":[12],"the":[13,33,65,93,113,235],"most":[14],"common":[15],"cause":[16],"of":[17,35,53,82,84,102,120,129,176,187,237],"late":[18],"death":[19],"after":[20,43,100,108,127,185],"transplantation.":[22,45],"Numerous":[23],"strategies":[24],"have":[25],"shown":[26],"variable":[27],"results.":[28],"We":[29],"sought":[30],"to":[31,60,228,251],"evaluate":[32],"effect":[34],"FK506":[36],"(tacrolimus)":[37],"on":[38],"bronchiolitis":[39],"obliterans":[40],"syndrome":[41],"(BOS)":[42],"METHODS:":[46],"A":[47,178],"single-center":[48],"open":[49],"study":[50,225],"was":[51,58,96,124,162,205],"conducted":[52],"15":[54],"patients":[55,68,95],"whose":[56],"treatment":[57],"converted":[59],"tacrolimus":[61,130,213],"from":[62],"cyclosporine.":[63,80],"Of":[64],"15,":[66],"12":[67,94],"had":[69,170],"BOS":[70],"characterized":[71],"loses":[74],"while":[78],"receiving":[79],"Rate":[81],"decline":[83,121,159,238],"forced":[85],"expiratory":[86],"volume":[87],"1":[89],"second":[90],"(FEV1)":[91],"for":[92,112],"calculated":[97],"before":[98,106],"and":[99,107,167,193,242],"administration":[101,128,186],"tacrolimus.":[103,188],"Biochemical":[104],"changes":[105,217],"conversion":[109],"were":[110],"compared":[111],"entire":[114],"group.":[115],"RESULTS:":[116],"Median":[117],"monthly":[118],"rate":[119,236],"FEV1":[123,161,219],"significantly":[125],"reduced":[126],"(5.3%":[131],"vs":[132],"1.1%;":[133],"p":[134],"=":[135,209],"0.002).":[136],"Forced":[137],"vital":[138],"capacity":[139],"did":[140],"not":[141,215],"change":[142,172,200],"significantly.":[143],"No":[144],"subjects":[145,169],"experienced":[146],"at":[147],"least":[148,155],"a":[149,156,232],"10%":[150,157,175],"improvement":[151],"FEV1.":[153],"At":[154],"further":[158],"noted":[163],"five":[165],"subjects,":[166],"seven":[168],"no":[171,243],"(i.e.,":[173],"within":[174],"baseline).":[177],"minor":[179],"nonsignificant":[180],"increase":[181],"creatinine":[183],"occurred":[184],"Blood":[189],"cell":[190],"count,":[191],"electrolytes,":[192],"liver":[194],"enzymes":[195],"remained":[196],"unchanged.":[197],"The":[198],"median":[199],"fasting":[202],"blood":[203],"glucose":[204],"+0.7":[206],"mmol/L":[207],"(p":[208],"0.02).":[210],"CONCLUSION:":[211],"Although":[212],"does":[214],"reverse":[216],"with":[220,231],"BOS,":[221],"this":[223,253],"nonrandomized":[224],"it":[226],"seemed":[227],"be":[229],"associated":[230],"decrease":[233],"significant":[244],"toxicity.":[246],"Further":[247],"studies":[248],"are":[249],"necessary":[250],"substantiate":[252],"observation.":[254]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}