{"id":"https://openalex.org/W16937178","doi":null,"title":"Myelin protein and lipid sorting mediated by glycosphingolipid-enriched microdomains","display_name":"Myelin protein and lipid sorting mediated by glycosphingolipid-enriched microdomains","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W16937178","mag":"16937178"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-1633","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI9832016","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100605436","display_name":"Tae\u2010Yoon Kim","orcid":"https://orcid.org/0000-0001-8749-6085","observed_orcids":["https://orcid.org/0000-0001-8749-6085"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tae\u2010Yoon Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8749-6085","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100605436"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelin-biogenesis","display_name":"myelin biogenesis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/galactocerebroside","display_name":"galactocerebroside","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sulfatide","display_name":"sulfatide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/udp-galactose-ceramide-galactosyltransferase","display_name":"UDP-galactose:ceramide galactosyltransferase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.8180000185966492},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2776931407","wikidata":"https://www.wikidata.org/wiki/Q418892","display_name":"Glycosphingolipid","level":2,"score":0.9022027254104614},{"id":"https://openalex.org/C134088382","wikidata":"https://www.wikidata.org/wiki/Q6556364","display_name":"Lipid microdomain","level":3,"score":0.6173828840255737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5628443956375122},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.5142204761505127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5017752647399902},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4006504416465759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25552505254745483},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16931480169296265},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12994161248207092},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-1633","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI9832016","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:dissertations-1633","doi":null,"is_oa":false,"landing_page_url":"http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9832016","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:16937178","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/AAI9832016/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W4295354870"],"related_works":["https://openalex.org/W1579537682","https://openalex.org/W1975798362","https://openalex.org/W9509700","https://openalex.org/W2098744846","https://openalex.org/W2160172354","https://openalex.org/W1991871623","https://openalex.org/W2529052722","https://openalex.org/W2103870501","https://openalex.org/W7099886844","https://openalex.org/W4404229621"],"abstract_inverted_index":{"Oligodendrocytes":[0],"(OLs)":[1],"produce":[2],"remarkable":[3],"quantities":[4],"of":[5,19,35,48,84,176,217,232,253,258,270,285,303,326],"proteins":[6,72,119,143,189,260,295],"and":[7,29,38,86,115,147,150,213,228,251,329],"lipids":[8],"during":[9],"myelin":[10,20,36,57,100,114,142,144,188,193,222,259,274,319],"biogenesis.":[11,101],"To":[12,53,102],"target":[13],"them":[14],"precisely":[15],"to":[16,92,117,180],"specific":[17],"domains":[18],"sheaths,":[21],"OLs":[22,95],"must":[23],"utilize":[24,96],"a":[25,204,219,242,265,278,311,323],"highly":[26],"regulated":[27,227],"sorting":[28,40,55,317],"transport":[30],"system.":[31],"A":[32,124],"better":[33],"understanding":[34],"protein":[37,125,146,153,206,283],"lipid":[39,97,122,271],"mechanisms":[41],"should":[42],"furnish":[43],"information":[44],"for":[45,50,173,267,314],"the":[46,64,79,128,139,151,170,174,230,247,268,301,327],"development":[47],"treatments":[49],"demyelinating":[51],"diseases.^":[52],"study":[54],"in":[56,78,88,99,127,191,197,207,246,273,277,318],"biogenesis,":[58,275],"this":[59,104,308],"thesis":[60,309],"is":[61],"focused":[62],"on":[63,300,322],"\"lipid":[65],"rafts\"":[66],"hypothesis,":[67],"which":[68],"states":[69],"that":[70,94,294],"certain":[71],"are":[73,296],"co-sorted":[74],"with":[75,121,136,237,262,291],"glycosphingolipid-enriched":[76,108],"microdomains":[77],"trans-Golgi":[80],"network.":[81],"The":[82,215,256,281],"enrichment":[83],"galactocerebroside":[85],"sulfatide":[87],"OLs/myelin":[89,210],"led":[90],"me":[91],"hypothesize":[93],"rafts":[98,272,332],"test":[103],"hypothesis:":[105],"(1)":[106],"Detergent-insoluble":[107],"complexes":[109],"(DIGs)":[110],"were":[111,156,178,195],"isolated":[112,161],"from":[113,162,182,199,209],"analyzed":[116],"identify":[118],"associated":[120,135,261,304],"rafts.":[123],"localized":[126],"paranodal":[129],"loops,":[130],"$2\\\\sp\\\\prime,3\\\\sp\\\\prime$-cyclic":[131],"nucleotide":[132],"3$\\\\sp\\\\prime$-phosphodiesterase":[133],"was":[134,211,225],"DIGs,":[137],"whereas":[138],"major":[140],"compact":[141],"basic":[145],"proteolipid":[148],"protein,":[149,224],"periaxonal":[152],"myelin-associated":[154],"glycoprotein":[155],"not.":[157],"(2)":[158],"Myelin":[159],"DIGs":[160,194,198,208,263],"knock-out":[163],"mice":[164],"lacking":[165],"UDP-galactose:":[166],"ceramide":[167],"galactosyltransferase":[168],"(CGT),":[169],"enzyme":[171],"responsible":[172],"synthesis":[175],"galactocerebroside,":[177],"compared":[179,290],"those":[181],"wild":[183],"type":[184],"animals.":[185],"Several":[186],"unidentified":[187],"present":[190],"normal":[192],"absent":[196],"CGT-deficient":[200,288],"mice.":[201],"(3)":[202],"MVP17,":[203,218],"highly-enriched":[205],"cloned":[212],"characterized.":[214],"expression":[216],"novel":[220,324],"tetraspan":[221],"membrane":[223],"developmentally":[226],"parallels":[229],"time-course":[231],"active":[233],"myelination.":[234],"Recombinant":[235],"MVP17":[236],"an":[238],"epitope":[239],"tag":[240],"showed":[241],"punctate":[243],"staining":[244],"pattern":[245],"cell":[248],"body,":[249],"processes":[250],"membranes":[252],"transfected":[254],"cells.^":[255],"presence":[257],"provides":[264,310],"clue":[266],"involvement":[269],"presumably":[276],"domain-specific":[279],"manner.":[280],"different":[282],"composition":[284],"glucocerebroside-rafts":[286],"(i.e.,":[287],"mice)":[289],"galactocerebroside-rafts":[292],"suggests":[293],"differently":[297],"sorted":[298],"based":[299,321],"character":[302],"lipids.":[305],"In":[306],"summary,":[307],"new":[312],"direction":[313],"studying":[315],"protein-lipid":[316],"biogenesis":[320],"hypothesis":[325],"domain-":[328],"lipid-specific":[330],"myelinogenic":[331],"formation.":[333],"^":[334]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}