{"id":"https://openalex.org/W1692895162","doi":null,"title":"Dissociated effects of physical activity and weight loss on fibrinogen concentrations and markers of red blood cell aggregation. Relevance for life style modification in atherothrombosis.","display_name":"Dissociated effects of physical activity and weight loss on fibrinogen concentrations and markers of red blood cell aggregation. Relevance for life style modification in atherothrombosis.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1692895162","mag":"1692895162","pmid":"https://pubmed.ncbi.nlm.nih.gov/17726255"},"language":"en","primary_location":{"id":"pmid:17726255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17726255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112618545","display_name":"Olga Raz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"O Raz","raw_affiliation_strings":["Nutrition and Diet Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Diet Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061280877","display_name":"Ori Rogowski","orcid":"https://orcid.org/0000-0002-7807-9471","observed_orcids":["https://orcid.org/0000-0002-7807-9471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Rogowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050856199","display_name":"Itzhak Shapira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Shapira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079488262","display_name":"Nitsan Maharshak","orcid":"https://orcid.org/0000-0002-9324-0024","observed_orcids":["https://orcid.org/0000-0002-9324-0024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Maharshak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048399419","display_name":"Y. Karni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Karni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111732783","display_name":"Shlomo A. Berliner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Berliner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2415,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.79840533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"3","first_page":"253","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9629999995231628},{"id":"https://openalex.org/keywords/red-blood-cell-aggregation","display_name":"erythrocyte aggregation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lifestyle-modification","display_name":"lifestyle modification","score":0.9660000205039978},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":0.9210000038146973},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9229999780654907},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.859000027179718},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8370000123977661},{"id":"https://openalex.org/keywords/biorheology","display_name":"biorheology","score":0.6809999942779541},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4269999861717224},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.43299999833106995},{"id":"https://openalex.org/keywords/lifestyle-intervention","display_name":"lifestyle intervention","score":0.3179999887943268},{"id":"https://openalex.org/keywords/lifestyle-modification-program","display_name":"lifestyle modification program","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.8107285499572754},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7506934404373169},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.6914279460906982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6901815533638},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6197243928909302},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5321300029754639},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.49580463767051697},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.4602481424808502},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.44947901368141174},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.435139536857605},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4150368571281433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3994256556034088},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3569543659687042}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004903","descriptor_name":"Erythrocyte Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17726255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17726255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},{"id":"mag:1692895162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17726255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W81013767","https://openalex.org/W233393858","https://openalex.org/W1727728043","https://openalex.org/W1785238995","https://openalex.org/W1969311688","https://openalex.org/W1973243032","https://openalex.org/W1978039741","https://openalex.org/W1980431670","https://openalex.org/W1988031515","https://openalex.org/W1992145690","https://openalex.org/W2005941538","https://openalex.org/W2015652521","https://openalex.org/W2021048165","https://openalex.org/W2025001402","https://openalex.org/W2026150929","https://openalex.org/W2026878362","https://openalex.org/W2054226753","https://openalex.org/W2056834577","https://openalex.org/W2059547681","https://openalex.org/W2066874480","https://openalex.org/W2070377185","https://openalex.org/W2077395975","https://openalex.org/W2085697534","https://openalex.org/W2086876265","https://openalex.org/W2095688768","https://openalex.org/W2095729983","https://openalex.org/W2096191357","https://openalex.org/W2101003091","https://openalex.org/W2110264385","https://openalex.org/W2117033473","https://openalex.org/W2117707671","https://openalex.org/W2148322270","https://openalex.org/W2151767156","https://openalex.org/W2160234571","https://openalex.org/W2160378223","https://openalex.org/W2222034223","https://openalex.org/W2281016161","https://openalex.org/W2288948543","https://openalex.org/W2332489171","https://openalex.org/W2396292535","https://openalex.org/W2404499512","https://openalex.org/W2913967451","https://openalex.org/W2947589465"],"related_works":["https://openalex.org/W1976239845","https://openalex.org/W2057321028","https://openalex.org/W2782451146","https://openalex.org/W2061615809","https://openalex.org/W1980444916","https://openalex.org/W2332489171","https://openalex.org/W1984866928","https://openalex.org/W2162177278","https://openalex.org/W4299636892","https://openalex.org/W4410953866"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"shown":[3],"that":[4,228],"weight":[5,79],"loss":[6,80],"and":[7,40,43,61,72,89,156,178,219,250],"physical":[8,74,236],"activity":[9,237],"contribute":[10],"to":[11,86,97,119,137,144,152,161,174,186],"a":[12,51,82,126,191,200,216],"better":[13],"biorheological":[14],"profile.":[15],"Yet,":[16],"the":[17,31,108,130,179,195,206,223,229,242],"concentrations":[18,112,196],"of":[19,53,64,84,113,197,208,222,232,245],"fibrinogen":[20,115,233],"are":[21,238],"not":[22],"always":[23],"reduced":[24,41],"following":[25,59,234],"life":[26,66],"style":[27],"modification.":[28],"We":[29],"evaluated":[30],"inter-relations":[32],"between":[33],"fibrinogen's":[34],"pro":[35],"red":[36,209],"cell":[37,210],"aggregation":[38,211],"potential":[39],"inflammation":[42],"improved":[44,247],"lipid":[45,248],"profile":[46,249],"as":[47,165,167,212],"anti-aggregating":[48],"forces":[49],"in":[50,91,103,129,169,194,205],"group":[52],"20":[54],"apparently":[55],"healthy":[56],"obese":[57],"volunteers":[58],"4":[60],"8":[62],"months":[63],"intensive":[65],"modification":[67],"program":[68],"which":[69],"included":[70],"diet":[71],"strenuous":[73],"activity.":[75],"A":[76],"significant":[77,127,192,201],"(p=0.005)":[78],"(from":[81,95,135,142,150,159,172],"mean+/-SD":[83],"121.4+/-20.9":[85],"98.0+/-21.3":[87],"kg)":[88],"decrease":[90,168],"body":[92],"mass":[93],"index":[94,182],"40.8+/-4.3":[96],"32.9+/-5.3":[98],"kg/m(2),":[99],"p=0.005)":[100,155],"was":[101,125,203],"noted":[102,204],"fourteen":[104],"individuals":[105],"who":[106],"completed":[107],"8-month":[109],"program.":[110],"The":[111],"clottable":[114,198],"rose":[116],"from":[117,184],"318+/-96":[118],"387+/-72":[120],"mg/dl":[121],"(p=0.012)":[122],"while":[123],"there":[124],"reduction":[128,202],"erythrocyte":[131],"sedimentation":[132],"rate":[133],"(ESR)":[134],"19.0+/-12.6":[136],"10.8+/-7.5":[138],"mm/h,":[139],"p=0.018),":[140],"triglycerides":[141],"143+/-80":[143],"80+/-44":[145],"mg/dl,":[146,154,163],"p=0.005),":[147],"LDL":[148],"cholesterol":[149,158],"128+/-34":[151],"103+/-17":[153],"total":[157],"211+/-40":[160],"171+/-17":[162],"p=0.007),":[164],"well":[166],"insulin":[170,180],"concentration":[171],"36.1+/-21.3":[173],"20.6+/-8.0":[175],"microu/ml,":[176],"p=0.01)":[177],"resistance":[181],"(HOMA-R,":[183],"9.1+/-6.4":[185],"4.9+/-2.1":[187],"glu*ins/405,":[188],"p=0.008).":[189],"Despite":[190],"increment":[193],"fibrinogen,":[199],"degree":[207],"measured":[213],"by":[214,241],"using":[215],"slide":[217],"test":[218],"direct":[220],"visualization":[221],"aggregates.":[224],"Our":[225],"conclusion":[226],"is":[227],"pro-aggregating":[230],"properties":[231,244],"intense":[235],"probable":[239],"counterbalanced":[240],"anti-aggregatory":[243],"an":[246,251],"attenuated":[252],"acute":[253],"phase":[254],"response.":[255]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}