{"id":"https://openalex.org/W1692438467","doi":"https://doi.org/10.1002/stem.1406","title":"Brief Report: Impaired Cell Reprogramming in Nonhomologous End Joining Deficient Cells","display_name":"Brief Report: Impaired Cell Reprogramming in Nonhomologous End Joining Deficient Cells","publication_year":2013,"publication_date":"2013-04-30","ids":{"openalex":"https://openalex.org/W1692438467","doi":"https://doi.org/10.1002/stem.1406","mag":"1692438467","pmid":"https://pubmed.ncbi.nlm.nih.gov/23630174"},"language":"en","primary_location":{"id":"doi:10.1002/stem.1406","doi":"https://doi.org/10.1002/stem.1406","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.1406","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066831844","display_name":"Francisco J. Molina-Est\u00e9vez","orcid":"https://orcid.org/0000-0001-9565-2199","observed_orcids":["https://orcid.org/0000-0001-9565-2199"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F. Javier Molina-Estevez","raw_affiliation_strings":["Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain","institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103483023","display_name":"M. Luz Lozano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Luz Lozano","raw_affiliation_strings":["Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain","institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044688513","display_name":"Susana Navarro","orcid":"https://orcid.org/0000-0002-6753-546X","observed_orcids":["https://orcid.org/0000-0002-6753-546X"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Navarro","raw_affiliation_strings":["Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain","institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030748926","display_name":"Yaima Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yaima Torres","raw_affiliation_strings":["Department of Regenerative Cardiology, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regenerative Cardiology, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040677048","display_name":"Ivana Grabund\u017eija","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ivana Grabundzija","raw_affiliation_strings":["Department of Mobile DNA, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mobile DNA, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066552100","display_name":"Zolt\u00e1n Ivics","orcid":"https://orcid.org/0000-0002-7803-6658","observed_orcids":["https://orcid.org/0000-0002-7803-6658"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zoltan Ivics","raw_affiliation_strings":["Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078541018","display_name":"Enrique Samper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Samper","raw_affiliation_strings":["Department of Regenerative Cardiology, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regenerative Cardiology, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010635866","display_name":"Juan Antonio Bueren","orcid":"https://orcid.org/0000-0002-3228-7013","observed_orcids":["https://orcid.org/0000-0002-3228-7013"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan A. Bueren","raw_affiliation_strings":["Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain","institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003429159","display_name":"Guillermo G\u00fcenechea","orcid":"https://orcid.org/0000-0001-7679-0895","observed_orcids":["https://orcid.org/0000-0001-7679-0895"]},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Guillermo Guenechea","raw_affiliation_strings":["Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopoietic Innovative Therapies (HIT), Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT)/Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain","institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003429159"],"corresponding_institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165411"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.0997,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74181464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"8","first_page":"1726","last_page":"1730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.8460000157356262},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.984000027179718},{"id":"https://openalex.org/keywords/dna-pkcs","display_name":"DNA-PKcs","score":0.9919999837875366},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.8009999990463257},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8389999866485596},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sa-beta-galactosidase","display_name":"SA-\u03b2-galactosidase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sleeping-beauty-transposon","display_name":"Sleeping Beauty transposon","score":0.7889999747276306},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9421652555465698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8485585451126099},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8413738012313843},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.6597914695739746},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5123673677444458},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5025224685668945},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.43014782667160034},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4260685443878174},{"id":"https://openalex.org/C193104389","wikidata":"https://www.wikidata.org/wiki/Q18032397","display_name":"Ku80","level":5,"score":0.42232221364974976},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.41631779074668884},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38134849071502686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37527933716773987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33080554008483887},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2911831736564636},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.20277073979377747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15845850110054016},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.07370787858963013},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07271173596382141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059766","descriptor_name":"DNA End-Joining Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/stem.1406","doi":"https://doi.org/10.1002/stem.1406","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.1406","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:23630174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23630174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:13028","doi":null,"is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/13028/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2624351292","doi":null,"is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/13028/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1155662037","display_name":null,"funder_award_id":"S2010/BMD-2420","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"},{"id":"https://openalex.org/G2694702136","display_name":"Comparative stem cell research in mouse and humans","funder_award_id":"230675","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1970232857","https://openalex.org/W1971496676","https://openalex.org/W1985178687","https://openalex.org/W2001620565","https://openalex.org/W2010901031","https://openalex.org/W2012918968","https://openalex.org/W2025987815","https://openalex.org/W2033617801","https://openalex.org/W2038815755","https://openalex.org/W2041153072","https://openalex.org/W2047036934","https://openalex.org/W2076047032","https://openalex.org/W2091660221","https://openalex.org/W2104209716","https://openalex.org/W2111920812","https://openalex.org/W2121825207","https://openalex.org/W2125987139","https://openalex.org/W2129042241","https://openalex.org/W2140337281","https://openalex.org/W2144512576","https://openalex.org/W2156063202","https://openalex.org/W2160532161","https://openalex.org/W2164618384","https://openalex.org/W2165530426"],"related_works":["https://openalex.org/W2624351292","https://openalex.org/W2171691529","https://openalex.org/W2091617602","https://openalex.org/W2080274817","https://openalex.org/W2164362605","https://openalex.org/W2099644703","https://openalex.org/W2057562851","https://openalex.org/W2010398956","https://openalex.org/W2955802740","https://openalex.org/W2598735320"],"abstract_inverted_index":{"Although":[0],"there":[1],"is":[2],"an":[3],"increasing":[4],"interest":[5],"in":[6,15,23,36,64,101,147],"defining":[7],"the":[8,18,49,91,116,121,125,135,153,158,200,204,221],"role":[9],"of":[10,20,31,51,73,128,137,140,162,167,203],"DNA":[11,32],"damage":[12],"response":[13],"mechanisms":[14],"cell":[16,77,215],"reprogramming,":[17],"relevance":[19],"proteins":[21],"participating":[22],"nonhomologous":[24],"end":[25],"joining":[26],"(NHEJ),":[27],"a":[28,66],"major":[29],"mechanism":[30],"double-strand":[33],"breaks":[34],"repair,":[35],"this":[37],"process":[38],"remains":[39],"to":[40,48,95,176,187,198,212],"be":[41,196],"investigated.":[42],"Herein,":[43],"we":[44],"present":[45],"data":[46],"related":[47],"reprogramming":[50,86,92,132,154,160],"primary":[52],"mouse":[53],"embryonic":[54],"fibroblasts":[55,129],"(MEF)":[56],"from":[57,82],"severe":[58],"combined":[59],"immunodeficient":[60],"(Scid)":[61],"mice":[62],"defective":[63],"DNA-PKcs,":[65],"key":[67],"protein":[68],"for":[69,157,220],"NHEJ.":[70],"Reduced":[71],"numbers":[72],"induced":[74],"pluripotent":[75],"stem":[76],"(iPSC)":[78],"colonies":[79],"were":[80,109,144],"generated":[81],"Scid":[83,106,117,148,163],"cells":[84],"using":[85],"lentiviral":[87],"vectors":[88],"(LV),":[89],"being":[90],"efficiency":[93],"fourfold":[94],"sevenfold":[96],"lower":[97],"than":[98],"that":[99],"observed":[100],"wt":[102,150],"cells.":[103],"Moreover,":[104],"these":[105],"iPSC-like":[107],"clones":[108],"prematurely":[110],"lost":[111],"or":[112],"differentiated":[113],"spontaneously.":[114],"While":[115],"mutation":[118,206],"neither":[119],"reduce":[120],"proliferation":[122],"rate":[123],"nor":[124],"transduction":[126],"efficacy":[127,161],"transduced":[130],"with":[131],"LV,":[133],"both":[134],"expression":[136],"SA-\u03b2-Gal":[138],"and":[139,185,209,216],"P16/INK(4a)":[141],"senescence":[142],"markers":[143],"highly":[145],"increased":[146],"versus":[149],"MEFs":[151],"during":[152,207],"process,":[155],"accounting":[156],"reduced":[159],"MEFs.":[164],"The":[165],"use":[166],"improved":[168],"Sleeping":[169],"Beauty":[170],"transposon/transposase":[171],"systems":[172],"allowed":[173],"us,":[174],"however,":[175],"isolate":[177],"DNA-PKcs-deficient":[178],"iPSCs":[179],"which":[180],"preserved":[181],"their":[182],"parental":[183],"genotype":[184],"hypersensitivity":[186],"ionizing":[188],"radiation.":[189],"This":[190],"new":[191],"disease-specific":[192],"iPSC":[193],"model":[194],"would":[195,210],"useful":[197],"understand":[199],"physiological":[201],"consequences":[202],"DNA-PKcs":[205],"development":[208],"help":[211],"improve":[213],"current":[214],"gene":[217],"therapy":[218],"strategies":[219],"disease.":[222]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}