{"id":"https://openalex.org/W16910600","doi":null,"title":"Monitoring of residual disease in chronic myelogenous leukemia by quantitative polymerase chain reaction.","display_name":"Monitoring of residual disease in chronic myelogenous leukemia by quantitative polymerase chain reaction.","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W16910600","mag":"16910600","pmid":"https://pubmed.ncbi.nlm.nih.gov/1602787"},"language":"en","primary_location":{"id":"pmid:1602787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1602787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042206697","display_name":"Thomas Lion","orcid":"https://orcid.org/0000-0001-9346-0994","observed_orcids":["https://orcid.org/0000-0001-9346-0994"]},"institutions":[{"id":"https://openalex.org/I4210123554","display_name":"St Anna Children's Hospital","ror":"https://ror.org/02qb3f692","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210123554"]},{"id":"https://openalex.org/I4388891777","display_name":"St. Anna Children's Cancer Research Institute","ror":"https://ror.org/05bd7c383","country_code":"AT","type":"nonprofit","lineage":["https://openalex.org/I4388891777"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"T Lion","raw_affiliation_strings":["Children's Cancer Research Institute, St Anna Kinderspital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Research Institute, St Anna Kinderspital, Vienna, Austria","institution_ids":["https://openalex.org/I4210123554","https://openalex.org/I4388891777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026358643","display_name":"Shai Izraeli","orcid":"https://orcid.org/0000-0002-6938-2540","observed_orcids":["https://orcid.org/0000-0002-6938-2540","https://orcid.org/0009-0001-2131-8638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Izraeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109125443","display_name":"Traudl Henn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Henn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086655791","display_name":"Alexander Gaiger","orcid":"https://orcid.org/0000-0001-6340-3446","observed_orcids":["https://orcid.org/0000-0001-6340-3446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Gaiger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021746823","display_name":"Wolfgang Mor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Mor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012680652","display_name":"Helmut Gadner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Gadner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7022,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.94997614,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"6","first_page":"495","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bcr-abl-rearrangement","display_name":"BCR-ABL rearrangement","score":0.8629999756813049},{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9039999842643738},{"id":"https://openalex.org/keywords/relapse-detection","display_name":"relapse detection","score":0.7620000243186951},{"id":"https://openalex.org/keywords/prognostic-monitoring","display_name":"prognostic monitoring","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.8661841154098511},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.7428483963012695},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.6524851322174072},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5750173330307007},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5318298935890198},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5218514204025269},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5043462514877319},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.49756672978401184},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44516465067863464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41712796688079834},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.41433200240135193},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.41216135025024414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40709030628204346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3861411511898041},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3386628031730652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26153677701950073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06627359986305237},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06421363353729248},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002873","descriptor_name":"Chromosome Fragility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016313","descriptor_name":"Genes, abl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1602787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1602787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"mag:16910600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1602787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044696883","https://openalex.org/W2468135478","https://openalex.org/W2089872439","https://openalex.org/W2396398508","https://openalex.org/W2400734080","https://openalex.org/W1652033010","https://openalex.org/W2438416536","https://openalex.org/W1971474320","https://openalex.org/W2067502899","https://openalex.org/W271139275"],"abstract_inverted_index":{"The":[0,30],"polymerase":[1],"chain":[2],"reaction":[3],"(PCR)":[4],"has":[5],"become":[6],"a":[7,150,159],"standard":[8],"method":[9],"for":[10,89,126,153],"highly":[11],"sensitive":[12],"detection":[13,38,52,154],"of":[14,33,39,53,66,74,81,92,101,105,131,134,142,155],"the":[15,34,37,51,63,67,79,87,95,127,132,135,146],"bcr/abl":[16,96,137],"rearrangement":[17,97],"in":[18,78],"patients":[19,107],"with":[20,115],"chronic":[21],"myelogenous":[22],"leukemia":[23,28],"(CML)":[24],"or":[25,45],"acute":[26],"lymphoblastic":[27],"(ALL).":[29],"exquisite":[31],"sensitivity":[32],"PCR":[35,71,88],"facilitates":[36],"residual":[40,55,82,136,143],"leukemic":[41],"cells":[42,93],"after":[43,46,108],"chemotherapy":[44],"bone":[47,109],"marrow":[48,110],"transplantation.":[49],"However,":[50],"minimal":[54],"disease":[56,144],"does":[57],"not":[58],"yield":[59],"any":[60],"information":[61],"on":[62],"malignant":[64],"potential":[65],"bcr/abl-rearranged":[68],"cells.":[69],"Qualitative":[70],"is":[72,124],"therefore":[73],"limited":[75],"prognostic":[76],"value":[77],"monitoring":[80,141],"leukemia.":[83],"We":[84],"have":[85],"adapted":[86],"quantitative":[90],"evaluation":[91],"carrying":[94],"and":[98,112],"by":[99,145],"means":[100],"two":[102],"exemplary":[103],"cases":[104],"CML":[106],"transplantation":[111],"under":[113],"treatment":[114],"alpha-interferon,":[116],"respectively,":[117],"we":[118],"show":[119],"that":[120],"this":[121],"new":[122],"technique":[123,147],"suitable":[125],"long":[128],"term":[129],"follow-up":[130],"activity":[133],"rearranged":[138],"clone.":[139],"Longitudinal":[140],"presented":[148],"provides":[149],"novel":[151],"tool":[152],"incipient":[156],"relapse":[157],"at":[158],"very":[160],"early":[161],"stage.":[162]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}