{"id":"https://openalex.org/W168938607","doi":null,"title":"Doxorubicin (adriamycin) cardiomyopathy.","display_name":"Doxorubicin (adriamycin) cardiomyopathy.","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W168938607","mag":"168938607","pmid":"https://pubmed.ncbi.nlm.nih.gov/6356608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1021516"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1021516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1021516","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1021516/pdf/westjmed00193-0052.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1021516/pdf/westjmed00193-0052.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060821862","display_name":"Emmanuel Saltiel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Saltiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110484689","display_name":"William Patrick McGuire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W McGuire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5129,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.80750532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"139","issue":"3","first_page":"332","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/anthracycline-based-chemotherapy","display_name":"anthracycline chemotherapy","score":0.746999979019165},{"id":"https://openalex.org/keywords/free-radical-production","display_name":"free radical generation","score":0.753000020980835},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.5640000104904175},{"id":"https://openalex.org/keywords/calcium-metabolism","display_name":"calcium metabolism","score":0.5960000157356262},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6940000057220459},{"id":"https://openalex.org/keywords/toxicity-monitoring","display_name":"toxicity monitoring","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.843999981880188},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.9369999766349792},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.6370000243186951},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nucleosides","display_name":"nucleosides","score":0.8450000286102295},{"id":"https://openalex.org/keywords/razoxane","display_name":"razoxane","score":0.6700000166893005},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/drug-administration-routes","display_name":"drug administration routes","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7338781952857971},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7185378670692444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.687355637550354},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.565642237663269},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5602232813835144},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5065468549728394},{"id":"https://openalex.org/C2909829705","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin Hydrochloride","level":4,"score":0.4866541028022766},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41990065574645996},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31671279668807983},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2800818681716919},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2720802426338196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27182137966156006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22745442390441895}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006334","descriptor_name":"Heart Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1021516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1021516","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1021516/pdf/westjmed00193-0052.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},{"id":"pmid:6356608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6356608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Western journal of medicine","raw_type":"Journal Article"},{"id":"mag:168938607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6356608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1021516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1021516","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1021516/pdf/westjmed00193-0052.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W168938607.pdf","grobid_xml":"https://content.openalex.org/works/W168938607.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W75292454","https://openalex.org/W76396401","https://openalex.org/W105786358","https://openalex.org/W119184795","https://openalex.org/W190603845","https://openalex.org/W193185337","https://openalex.org/W1212503504","https://openalex.org/W1489729011","https://openalex.org/W1499053016","https://openalex.org/W1517318768","https://openalex.org/W1517739073","https://openalex.org/W1604385172","https://openalex.org/W1747884574","https://openalex.org/W1828224642","https://openalex.org/W1920198420","https://openalex.org/W1969262864","https://openalex.org/W1975313849","https://openalex.org/W1976016662","https://openalex.org/W1977105311","https://openalex.org/W1982230933","https://openalex.org/W1992786087","https://openalex.org/W1998340267","https://openalex.org/W1999514033","https://openalex.org/W2003384266","https://openalex.org/W2006761212","https://openalex.org/W2016725675","https://openalex.org/W2023704885","https://openalex.org/W2033663547","https://openalex.org/W2047966108","https://openalex.org/W2049129583","https://openalex.org/W2052145586","https://openalex.org/W2058563509","https://openalex.org/W2065634263","https://openalex.org/W2065804849","https://openalex.org/W2067982278","https://openalex.org/W2076315300","https://openalex.org/W2082231147","https://openalex.org/W2087585549","https://openalex.org/W2100809362","https://openalex.org/W2124537543","https://openalex.org/W2140125008","https://openalex.org/W2142246315","https://openalex.org/W2161993306","https://openalex.org/W2167397260","https://openalex.org/W2204344584","https://openalex.org/W2281334649","https://openalex.org/W2295905407","https://openalex.org/W2331770504","https://openalex.org/W2333791129","https://openalex.org/W2334985088","https://openalex.org/W2336175609","https://openalex.org/W2343696406","https://openalex.org/W2395610377","https://openalex.org/W2396625328","https://openalex.org/W2397291197","https://openalex.org/W2399481698","https://openalex.org/W2399787560","https://openalex.org/W2401669544","https://openalex.org/W2402391960","https://openalex.org/W2402495289","https://openalex.org/W2403513479","https://openalex.org/W2408758336","https://openalex.org/W2409413157","https://openalex.org/W2411167732","https://openalex.org/W2411263633","https://openalex.org/W2411352379","https://openalex.org/W2411689595","https://openalex.org/W2412098538","https://openalex.org/W2412656576","https://openalex.org/W2414848246","https://openalex.org/W2415768629","https://openalex.org/W2416349087","https://openalex.org/W2416631037","https://openalex.org/W2417880986","https://openalex.org/W2418284759","https://openalex.org/W2418397680","https://openalex.org/W2418931485","https://openalex.org/W2432349517","https://openalex.org/W2468161903","https://openalex.org/W2475187624","https://openalex.org/W4211136833","https://openalex.org/W4249717296","https://openalex.org/W4250948645","https://openalex.org/W4290689941","https://openalex.org/W4409139070"],"related_works":["https://openalex.org/W7097004397","https://openalex.org/W2155890549","https://openalex.org/W943562855","https://openalex.org/W2586290265","https://openalex.org/W76396401","https://openalex.org/W1994415831","https://openalex.org/W2410520435","https://openalex.org/W2037918628","https://openalex.org/W2162689981","https://openalex.org/W127420321"],"abstract_inverted_index":{"Despite":[0],"its":[1],"vast":[2],"utility":[3],"in":[4,62],"clinical":[5],"oncology,":[6],"the":[7,26,68],"use":[8],"of":[9,36,43,52,56,67,96],"doxorubicin":[10],"hydrochloride":[11],"(Adriamycin)":[12],"is":[13],"limited":[14],"by":[15,74],"a":[16],"potentially":[17],"fatal":[18],"cardiomyopathy.":[19],"The":[20],"following":[21],"critical":[22],"review,":[23],"which":[24],"examines":[25],"natural":[27],"course,":[28],"histopathologic":[29],"effects,":[30],"risk":[31],"factors":[32],"and":[33,60,87,89,93],"monitoring":[34],"indicators":[35],"this":[37],"toxicity,":[38],"also":[39],"analyzes":[40],"recent":[41],"research":[42],"proposed":[44],"mechanisms,":[45],"including":[46],"free":[47],"radical":[48],"formation":[49],"with":[50],"depletion":[51],"detoxifying":[53],"enzymes,":[54],"inhibition":[55],"vital":[57],"enzyme":[58],"systems":[59],"alterations":[61],"relative":[63],"calcium":[64],"concentrations.":[65],"Prevention":[66],"adverse":[69],"reaction":[70],"has":[71],"been":[72],"attempted":[73],"using":[75],"such":[76],"agents":[77],"as":[78],"alpha-tocopherol,":[79],"selenium":[80],"sulfide,":[81],"coenzyme":[82],"Q(10),":[83],"sulfhydryl":[84],"donors,":[85],"nucleosides":[86],"razoxane,":[88],"via":[90],"liposomal":[91],"carriage":[92],"alternative":[94],"methods":[95],"administration.":[97]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
