{"id":"https://openalex.org/W1689023116","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1182.8","title":"An intrinsically disordered region of the transcription factor, NFAT5, becomes more ordered with an increase in osmolality (1182.8)","display_name":"An intrinsically disordered region of the transcription factor, NFAT5, becomes more ordered with an increase in osmolality (1182.8)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1689023116","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1182.8","mag":"1689023116"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1182.8","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1182.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1182.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040251156","display_name":"Jenna F. DuMond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna DuMond","raw_affiliation_strings":["Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007780827","display_name":"Raj Kumar","orcid":"https://orcid.org/0000-0003-2328-8521","observed_orcids":["https://orcid.org/0000-0003-2328-8521","https://orcid.org/0000-0001-7479-696X"]},"institutions":[{"id":"https://openalex.org/I75747061","display_name":"Geisinger College of Health Sciences","ror":"https://ror.org/04bqfk210","country_code":"US","type":"education","lineage":["https://openalex.org/I54713919","https://openalex.org/I75747061"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Kumar","raw_affiliation_strings":["Department of Basic Sciences The Commonwealth Medical College Scranton PA United States","2Department of Basic Sciences The Commonwealth Medical College Scranton PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences The Commonwealth Medical College Scranton PA United States","institution_ids":["https://openalex.org/I75747061"]},{"raw_affiliation_string":"2Department of Basic Sciences The Commonwealth Medical College Scranton PA United States","institution_ids":["https://openalex.org/I75747061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076493214","display_name":"Kevin Ramkissoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Ramkissoon","raw_affiliation_strings":["Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023933647","display_name":"Yuichiro Izumi","orcid":"https://orcid.org/0000-0003-0827-9619","observed_orcids":["https://orcid.org/0000-0003-0827-9619"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuichiro Izumi","raw_affiliation_strings":["Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brad Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Thompson","raw_affiliation_strings":["Department of Biochemistry &amp; Molecular Biology University of Texas Medical Branch Galveston TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry &amp; Molecular Biology University of Texas Medical Branch Galveston TX United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice Burg","raw_affiliation_strings":["Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051074151","display_name":"Joan D. Ferraris","orcid":"https://orcid.org/0000-0003-4696-2347","observed_orcids":["https://orcid.org/0000-0003-4696-2347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Ferraris","raw_affiliation_strings":["Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Center National Heart Lung and Blood Institute National Institutes of Health BETHESDA MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"1Systems Biology Center National Heart, Lung and Blood Institute, National Institutes of Health Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05539314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nfat5","display_name":"NFAT5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.9340000152587891},{"id":"https://openalex.org/keywords/osmolality","display_name":"osmolality","score":0.9919999837875366},{"id":"https://openalex.org/keywords/trehalose","display_name":"trehalose","score":0.8949999809265137},{"id":"https://openalex.org/keywords/osmolytes","display_name":"osmolytes","score":0.800000011920929},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6010000109672546},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8130000233650208},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.5809999704360962},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.6710000038146973},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C127160389","wikidata":"https://www.wikidata.org/wiki/Q415608","display_name":"Osmolyte","level":2,"score":0.7816582918167114},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7379919290542603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5771611928939819},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49945878982543945},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.43455666303634644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42754024267196655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2948060631752014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27530303597450256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15905484557151794}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1182.8","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1182.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1182.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3047240720","https://openalex.org/W1100527087","https://openalex.org/W2130927156","https://openalex.org/W2288496836","https://openalex.org/W2528948968","https://openalex.org/W2376848345","https://openalex.org/W2020484450","https://openalex.org/W2096981766","https://openalex.org/W2073180248","https://openalex.org/W4407737904"],"abstract_inverted_index":{"Hypertonicity":[0],"stimulates":[1],"NFAT5":[2,37,64,109,133,145],"nuclear":[3],"localization":[4],"and":[5,31,47,101,131],"transactivating":[6],"activity.":[7],"Many":[8],"transcription":[9],"factors":[10],"are":[11],"known":[12],"to":[13,40,58,80,125],"contain":[14,41],"intrinsically":[15],"disordered":[16],"regions":[17],"(IDRs)":[18],"which":[19],"become":[20],"more":[21],"structured":[22],"with":[23,75,103],"local":[24],"environmental":[25],"changes":[26],"such":[27],"as":[28],"osmolality,":[29],"temperature":[30],"tonicity.":[32],"The":[33],"N\u2010terminal":[34,61],"region":[35],"of":[36,53,63,71,144,160],"is":[38],"predicted":[39],"an":[42,66,126],"IDR.":[43],"Using":[44],"far\u2010UV":[45],"CD":[46],"fluorescence":[48],"we":[49,92],"found":[50],"that":[51,118],"addition":[52],"the":[54,59,69,72],"organic":[55],"osmolyte":[56],"trehalose":[57],"purified":[60],"IDR":[62,110,129],"caused":[65],"increase":[67,127],"in":[68,99,121,128,140],"structure":[70,87,100,130],"IDR,":[73],"consistent":[74],"a":[76,95,119],"2\u2010state":[77],"transition,":[78],"ID":[79],"native.":[81],"To":[82],"investigate":[83],"how":[84],"this":[85],"increased":[86],"affects":[88,132],"cellular":[89,147],"protein\u2010protein":[90,134],"interactions,":[91],"looked":[93],"for":[94],"correlation":[96],"between":[97],"change":[98,120],"association":[102],"other":[104],"proteins.":[105],"Mass":[106],"spectrometry":[107],"identified":[108],"protein":[111],"binding":[112],"partners.":[113],"We":[114],"thus":[115],"have":[116],"demonstrated":[117],"osmolality":[122],"gives":[123],"rise":[124],"interactions.":[135],"These":[136],"data":[137],"will":[138],"aid":[139],"understanding":[141],"transcriptional":[142],"upregulation":[143],"under":[146],"osmotic":[148],"stress.":[149],"Grant":[150],"Funding":[151],"Source":[152],":":[153],"Supported":[154],"by":[155],"SBC,":[156],"NHLBI,":[157],"National":[158],"Institutes":[159],"Health,":[161],"Intramural":[162],"Research":[163],"Program":[164]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
