{"id":"https://openalex.org/W168673227","doi":null,"title":"Prediction Of Membrane Proteins Using Machine Learning Approaches","display_name":"Prediction Of Membrane Proteins Using Machine Learning Approaches","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W168673227","mag":"168673227"},"language":"en","primary_location":{"id":"mag:168673227","doi":null,"is_oa":false,"landing_page_url":"http://prr.hec.gov.pk/jspui/handle/123456789/1640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037634953","display_name":"Maqsood Hayat","orcid":"https://orcid.org/0000-0001-5456-2664","observed_orcids":["https://orcid.org/0000-0001-5456-2664"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maqsood Hayat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5456-2664","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037634953"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-protein-prediction","display_name":"membrane protein prediction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/membrane-protein-structure-prediction","display_name":"membrane protein structure prediction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.996999979019165},{"id":"https://openalex.org/keywords/ensemble-classification","display_name":"ensemble classification","score":0.6349999904632568},{"id":"https://openalex.org/keywords/weighted-random-forest","display_name":"weighted random forest","score":0.7879999876022339},{"id":"https://openalex.org/keywords/position-specific-scoring-matrix","display_name":"position weight matrices","score":0.6489999890327454},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"feature extraction","score":0.36399999260902405},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.38199999928474426},{"id":"https://openalex.org/keywords/protein-sequence-representation","display_name":"protein sequence representation","score":0.41600000858306885},{"id":"https://openalex.org/keywords/genetic-programming","display_name":"genetic programming","score":0.5130000114440918},{"id":"https://openalex.org/keywords/fuzzy-k-nearest-neighbor","display_name":"fuzzy k-nearest neighbor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/singular-value-decomposition","display_name":"singular value decomposition","score":0.6480000019073486},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.7481323480606079},{"id":"https://openalex.org/C146033667","wikidata":"https://www.wikidata.org/wiki/Q18033204","display_name":"Vesicle-associated membrane protein 8","level":4,"score":0.5341426730155945},{"id":"https://openalex.org/C560191","wikidata":"https://www.wikidata.org/wiki/Q417736","display_name":"Peripheral membrane protein","level":5,"score":0.5125882029533386},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4820752739906311},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4773152768611908},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.4309685230255127},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40601855516433716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3770235478878021},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.3702309727668762},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36589157581329346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33386218547821045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3252427577972412}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:168673227","doi":null,"is_oa":false,"landing_page_url":"http://prr.hec.gov.pk/jspui/handle/123456789/1640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":165,"referenced_works":["https://openalex.org/W2871219","https://openalex.org/W75892284","https://openalex.org/W205578041","https://openalex.org/W1227091703","https://openalex.org/W1251243258","https://openalex.org/W1489446631","https://openalex.org/W1525523977","https://openalex.org/W1526754730","https://openalex.org/W1534925464","https://openalex.org/W1563855921","https://openalex.org/W1605593725","https://openalex.org/W1821139715","https://openalex.org/W1860302132","https://openalex.org/W1967967346","https://openalex.org/W1970736040","https://openalex.org/W1972475361","https://openalex.org/W1975304761","https://openalex.org/W1978136924","https://openalex.org/W1978650123","https://openalex.org/W1979228662","https://openalex.org/W1979377731","https://openalex.org/W1979434225","https://openalex.org/W1981024439","https://openalex.org/W1982892983","https://openalex.org/W1986897081","https://openalex.org/W1989932358","https://openalex.org/W1990215053","https://openalex.org/W1990960780","https://openalex.org/W1991170256","https://openalex.org/W1991576509","https://openalex.org/W1991608395","https://openalex.org/W1991655565","https://openalex.org/W1992577925","https://openalex.org/W1993346240","https://openalex.org/W1996177050","https://openalex.org/W1997456657","https://openalex.org/W1998545976","https://openalex.org/W1999455032","https://openalex.org/W2001028520","https://openalex.org/W2001808731","https://openalex.org/W2004549388","https://openalex.org/W2009703007","https://openalex.org/W2010818132","https://openalex.org/W2010877280","https://openalex.org/W2012534599","https://openalex.org/W2012686113","https://openalex.org/W2013458354","https://openalex.org/W2013475505","https://openalex.org/W2014840904","https://openalex.org/W2015556108","https://openalex.org/W2018235493","https://openalex.org/W2020194549","https://openalex.org/W2020652394","https://openalex.org/W2021312899","https://openalex.org/W2022761661","https://openalex.org/W2024572834","https://openalex.org/W2025131366","https://openalex.org/W2026582002","https://openalex.org/W2026685617","https://openalex.org/W2026828269","https://openalex.org/W2026907061","https://openalex.org/W2028332059","https://openalex.org/W2029580264","https://openalex.org/W2029904979","https://openalex.org/W2030650052","https://openalex.org/W2030793934","https://openalex.org/W2033326122","https://openalex.org/W2033468519","https://openalex.org/W2034070267","https://openalex.org/W2034410027","https://openalex.org/W2036956828","https://openalex.org/W2037032199","https://openalex.org/W2038474719","https://openalex.org/W2040895929","https://openalex.org/W2043976158","https://openalex.org/W2043978551","https://openalex.org/W2045088880","https://openalex.org/W2053963319","https://openalex.org/W2053979203","https://openalex.org/W2059293530","https://openalex.org/W2059451993","https://openalex.org/W2059846299","https://openalex.org/W2061798849","https://openalex.org/W2064450641","https://openalex.org/W2065667921","https://openalex.org/W2069891540","https://openalex.org/W2071282889","https://openalex.org/W2072220895","https://openalex.org/W2072227363","https://openalex.org/W2074266029","https://openalex.org/W2074370114","https://openalex.org/W2076974281","https://openalex.org/W2082605863","https://openalex.org/W2083097837","https://openalex.org/W2085022192","https://openalex.org/W2089606003","https://openalex.org/W2092247420","https://openalex.org/W2092349963","https://openalex.org/W2093577984","https://openalex.org/W2093730380","https://openalex.org/W2094801954","https://openalex.org/W2096869074","https://openalex.org/W2097870001","https://openalex.org/W2098029171","https://openalex.org/W2098463207","https://openalex.org/W2101466114","https://openalex.org/W2101971471","https://openalex.org/W2102354653","https://openalex.org/W2103250033","https://openalex.org/W2105255303","https://openalex.org/W2110659301","https://openalex.org/W2111119053","https://openalex.org/W2112076978","https://openalex.org/W2112905569","https://openalex.org/W2114010544","https://openalex.org/W2114083522","https://openalex.org/W2114531694","https://openalex.org/W2115840790","https://openalex.org/W2117919289","https://openalex.org/W2118467383","https://openalex.org/W2119723504","https://openalex.org/W2120026469","https://openalex.org/W2120684043","https://openalex.org/W2121547673","https://openalex.org/W2123832393","https://openalex.org/W2127177253","https://openalex.org/W2127686215","https://openalex.org/W2128941049","https://openalex.org/W2129838159","https://openalex.org/W2133312664","https://openalex.org/W2133650672","https://openalex.org/W2133917958","https://openalex.org/W2134665553","https://openalex.org/W2136540712","https://openalex.org/W2137095432","https://openalex.org/W2138217546","https://openalex.org/W2143814286","https://openalex.org/W2144112248","https://openalex.org/W2145957695","https://openalex.org/W2146241755","https://openalex.org/W2146640609","https://openalex.org/W2149723649","https://openalex.org/W2149730127","https://openalex.org/W2150044256","https://openalex.org/W2151156268","https://openalex.org/W2152748513","https://openalex.org/W2152770371","https://openalex.org/W2152800101","https://openalex.org/W2152953137","https://openalex.org/W2154053567","https://openalex.org/W2156781984","https://openalex.org/W2156909104","https://openalex.org/W2156955619","https://openalex.org/W2158623906","https://openalex.org/W2158714788","https://openalex.org/W2158906453","https://openalex.org/W2158934641","https://openalex.org/W2159160074","https://openalex.org/W2160020195","https://openalex.org/W2160356737","https://openalex.org/W2163137692","https://openalex.org/W2165724689","https://openalex.org/W2167114860","https://openalex.org/W2574994322","https://openalex.org/W2911748641"],"related_works":["https://openalex.org/W2898323771","https://openalex.org/W2026650804","https://openalex.org/W1986897081","https://openalex.org/W4406881361","https://openalex.org/W2024767324","https://openalex.org/W2032188627","https://openalex.org/W3135990792","https://openalex.org/W1977852743","https://openalex.org/W2047046796","https://openalex.org/W2998559844"],"abstract_inverted_index":{"Membrane":[0],"proteins":[1,47,55,66,76,380],"are":[2,24,34,77,116,132,251,314,336],"the":[3,42,51,62,96,107,124,141,152,155,197,225,231,289,303,341,347,369,403],"basic":[4],"constituent":[5],"of":[6,15,19,21,32,45,53,64,98,109,127,143,157,216,228,233,246,261,270,292,308,350,356,368],"a":[7,16,188,202,208,211,300,383],"cell":[8],"that":[9,346,374],"manage":[10],"intra":[11],"and":[12,102,181,267,322,332,359,392,412],"extracellular":[13],"processes":[14],"cell.About":[17],"20-30%":[18],"genes":[20],"eukaryotic":[22],"organisms":[23],"encoded":[25],"from":[26,79,253],"membrane":[27,38,46,54,65,75,99,110,129,209,217,234,243,310,379],"proteins.In":[28,244],"addition,":[29,402],"almost":[30],"50%":[31],"drugs":[33],"directly":[35],"targeted":[36],"against":[37],"proteins.":[39],"Owing":[40],"to":[41,120,277,365,399,410],"significant":[43,384],"role":[44,385],"in":[48,92,118,147,185,199,306,354,386,396,414],"living":[49],"organisms,":[50],"identification":[52],"with":[56,149,170,325],"substantial":[57],"accuracy":[58],"is":[59,70,160,168,194,205,222,236,275,285,296,362],"essential.":[60],"However,":[61],"annotation":[63],"through":[67],"conventional":[68],"methods":[69],"difficult,":[71],"sometimes":[72],"even":[73],"impossible.Therefore,":[74],"predicted":[78,133],"topogenic":[80],"sequences":[81,255,313],"using":[82,134,174],"computational":[83],"intelligence":[84],"techniques.In":[85],"this":[86,229],"study,":[87,343],"we":[88,344,372],"conducted":[89],"our":[90,351,375],"research":[91],"two":[93,200,257],"phases":[94],"regarding":[95,106],"prediction":[97,108,198,348,361],"protein":[100,111,130,136,203,235,254,312],"types":[101,131,291,358],"structures.":[103],"In":[104,214,224],"Phase-I,":[105],"types,":[112],"four":[113],"different":[114,290],"ways":[115],"explored":[117,252],"order":[119],"enhance":[121],"true":[122],"prediction.\r\nIn":[123],"first":[125],"part":[126,162,186],"phase-I,":[128],"Composite":[135],"sequence":[137],"representation":[138],"followed":[139],"by":[140,256,287,316],"application":[142],"principal":[144],"component":[145],"analysis":[146],"conjunction":[148],"individual":[150],"classifiers.In":[151],"second":[153,226],"part,":[154],"notion":[156],"ensemble":[158],"classification":[159,301,339],"utilized.In":[161],"three,":[163],"an":[164],"error":[165],"correction":[166],"code":[167],"incorporated":[169],"Support":[171],"Vector":[172],"Machine":[173],"evolutionary":[175],"profiles":[176],"(Position":[177],"Specific":[178],"Scoring":[179],"Matrix)":[180],"SAAC":[182,323],"based":[183],"features.Finally,":[184],"four,":[187],"two-layer":[189],"web":[190,405],"predictor":[191],"Mem-":[192],"PHybrid":[193],"developed.Mem-PHybrid":[195],"accomplishes":[196],"steps.First,":[201],"query":[204],"identified":[206],"as":[207,238,299,338],"or":[210,241],"non-membrane":[212],"protein.":[213],"case":[215,245,307,355],"protein,":[218],"then":[219,297],"its":[220],"type":[221],"predicted.":[223],"phase":[227],"research,":[230],"structure":[232],"recognized":[237],"alpha-helix":[239],"transmembrane":[240,248],"outer":[242,309],"alphahelix":[247],"proteins,":[249,311],"features":[250],"feature":[258,283],"extraction":[259],"schemes":[260],"distinct":[262],"natures;":[263],"including":[264],"physicochemical":[265],"properties":[266],"compositional":[268],"index":[269],"amino":[271],"acids.Singular":[272],"value":[273],"decomposition":[274],"employed":[276],"extract":[278],"high":[279],"variation":[280],"features.A":[281],"hybrid":[282,327],"vector":[284],"formed":[286],"combining":[288],"features.Weighted":[293],"Random":[294],"Forest":[295],"used":[298],"algorithm.On":[302],"other":[304],"hand,":[305],"represented":[315],"Amino":[317],"acid":[318],"composition,":[319,321],"PseAA":[320],"along":[324],"their":[326],"models.Genetic":[328],"programming,":[329],"K-nearest":[330,334],"neighbor,":[331],"fuzzy":[333],"neighbor":[335],"adopted":[337],"algorithms.\r\nThrough":[340],"simulation":[342],"observed":[345],"performance":[349],"proposed":[352,376],"approaches":[353],"both":[357],"structures":[360],"better":[363],"compared":[364],"existing":[366],"state":[367],"arts/approaches.":[370],"Finally,":[371],"conclude":[373],"approach":[377],"for":[378],"might":[381,394],"play":[382],"Computational":[387],"Biology,":[388,390],"Molecular":[389],"Bioinformatics,":[391],"thus":[393],"help":[395],"applications":[397],"related":[398,404],"drug":[400],"discovery.In":[401],"predictors":[406],"provide":[407],"sufficient":[408],"information":[409],"researchers":[411],"academicians":[413],"future":[415],"research.":[416]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}