{"id":"https://openalex.org/W1686523227","doi":"https://doi.org/10.22435/jki.v5i1.4080.1-10","title":"Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia","display_name":"Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia","publication_year":2015,"publication_date":"2015-05-22","ids":{"openalex":"https://openalex.org/W1686523227","doi":"https://doi.org/10.22435/jki.v5i1.4080.1-10","mag":"1686523227"},"language":"id","primary_location":{"id":"doi:10.22435/jki.v5i1.4080.1-10","doi":"https://doi.org/10.22435/jki.v5i1.4080.1-10","is_oa":true,"landing_page_url":"https://doi.org/10.22435/jki.v5i1.4080.1-10","pdf_url":null,"source":{"id":"https://openalex.org/S4210232905","display_name":"Jurnal Kefarmasian Indonesia","issn_l":"2085-675X","issn":["2085-675X","2354-8770"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315050","host_organization_name":"National Institute of Health Research and Development","host_organization_lineage":["https://openalex.org/P4310315050"],"host_organization_lineage_names":["National Institute of Health Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kefarmasian Indonesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.22435/jki.v5i1.4080.1-10","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036928295","display_name":"Nanang Yunarto","orcid":"https://orcid.org/0000-0003-3097-0684","observed_orcids":["https://orcid.org/0000-0003-3097-0684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanang Yunarto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001284196","display_name":"Berna Elya","orcid":"https://orcid.org/0000-0003-2904-6515","observed_orcids":["https://orcid.org/0000-0003-2904-6515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Berna Elya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070297963","display_name":"Laurentia Konadi Mihardja","orcid":"https://orcid.org/0000-0003-4600-9775","observed_orcids":["https://orcid.org/0000-0003-4600-9775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurentia Konadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2244,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.46799163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uncaria-gambir","display_name":"Uncaria gambir","score":0.984000027179718},{"id":"https://openalex.org/keywords/ethyl-acetate-fraction","display_name":"ethyl acetate fraction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.6970000267028809},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.6600000262260437},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.828000009059906},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9309999942779541},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":1.0},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dietary-saturated-fat","display_name":"dietary saturated fat","score":0.800000011920929},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.751167893409729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6789891123771667},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.6742360591888428},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6409108638763428},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.5559805631637573},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.5364760756492615},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.4955543279647827},{"id":"https://openalex.org/C3018223157","wikidata":"https://www.wikidata.org/wiki/Q7233257","display_name":"Positive control","level":2,"score":0.4911458194255829},{"id":"https://openalex.org/C2779431889","wikidata":"https://www.wikidata.org/wiki/Q415007","display_name":"Catechin","level":4,"score":0.4671567976474762},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20737847685813904},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2030109167098999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17769181728363037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1769801676273346},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.16744127869606018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12488657236099243},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.0994979739189148},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.22435/jki.v5i1.4080.1-10","doi":"https://doi.org/10.22435/jki.v5i1.4080.1-10","is_oa":true,"landing_page_url":"https://doi.org/10.22435/jki.v5i1.4080.1-10","pdf_url":null,"source":{"id":"https://openalex.org/S4210232905","display_name":"Jurnal Kefarmasian Indonesia","issn_l":"2085-675X","issn":["2085-675X","2354-8770"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315050","host_organization_name":"National Institute of Health Research and Development","host_organization_lineage":["https://openalex.org/P4310315050"],"host_organization_lineage_names":["National Institute of Health Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kefarmasian Indonesia","raw_type":"journal-article"},{"id":"pmh:oai:jkefarind.com:article/2959","doi":null,"is_oa":true,"landing_page_url":"https://jkefarind.com/index.php/jki/article/view/2959","pdf_url":"https://jkefarind.com/index.php/jki/article/download/2959/1656","source":{"id":"https://openalex.org/S4210232905","display_name":"Jurnal Kefarmasian Indonesia","issn_l":"2085-675X","issn":["2085-675X","2354-8770"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315050","host_organization_name":"National Institute of Health Research and Development","host_organization_lineage":["https://openalex.org/P4310315050"],"host_organization_lineage_names":["National Institute of Health Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2085-675X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5f20122ae8094ed78137984806d71a52","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5f20122ae8094ed78137984806d71a52","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jurnal Kefarmasian Indonesia, Vol 5, Iss 1, Pp 1-10 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22435/jki.v5i1.4080.1-10","doi":"https://doi.org/10.22435/jki.v5i1.4080.1-10","is_oa":true,"landing_page_url":"https://doi.org/10.22435/jki.v5i1.4080.1-10","pdf_url":null,"source":{"id":"https://openalex.org/S4210232905","display_name":"Jurnal Kefarmasian Indonesia","issn_l":"2085-675X","issn":["2085-675X","2354-8770"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315050","host_organization_name":"National Institute of Health Research and Development","host_organization_lineage":["https://openalex.org/P4310315050"],"host_organization_lineage_names":["National Institute of Health Research and Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kefarmasian Indonesia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1686523227.pdf","grobid_xml":"https://content.openalex.org/works/W1686523227.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7051765271","https://openalex.org/W3134449401","https://openalex.org/W4226052228","https://openalex.org/W4313494899","https://openalex.org/W4402497437","https://openalex.org/W2185481271","https://openalex.org/W3005475438","https://openalex.org/W4409727523","https://openalex.org/W2012528694","https://openalex.org/W2028447858"],"abstract_inverted_index":{"Hyperlipidemia":[0],"is":[1,183],"the":[2,40,118,125,184,199],"main":[3],"risk":[4],"factor":[5],"for":[6,113,127],"atherosclerosis":[7],"and":[8,95,109,147,159,170],"coronary":[9],"heart":[10],"disease.":[11],"Ethyl":[12],"acetate":[13,45,186],"fraction":[14,46,187],"of":[15,24,43,47,56,141,188],"gambier":[16,48,189],"leaves":[17,49,190],"extract":[18,50,191],"(Uncaria":[19],"gambir":[20],"Roxb.)":[21],"contains":[22],"catechin":[23],"secondary":[25],"metabolites":[26],"which":[27],"have":[28],"potency":[29],"to":[30,38],"be":[31],"used":[32],"as":[33],"antihyperlipidemic.":[34],"This":[35],"study":[36],"aimed":[37],"examine":[39],"antihyperlipidemic":[41],"effect":[42],"ethyl":[44,185],"in":[51,117],"vivo.":[52],"Thirty":[53],"six":[54,67],"males":[55],"Sprague":[57],"Dawley":[58],"strain,":[59],"2,5":[60],"months":[61],"old,":[62],"were":[63,104,123],"randomly":[64],"divided":[65],"into":[66],"groups:":[68],"normal":[69,119],"group,":[70],"negative":[71,136],"group":[72,76],"(distilled":[73],"water),":[74],"positive":[75],"(simvastatin":[77],"2":[78],"mg/200":[79,85,91,98,194],"g":[80,86,92,99,195],"bw),":[81],"dose":[82,138,164,197],"I":[83,154],"(5":[84],"bw":[87,93,100],"fraction),":[88],"II":[89,165],"(10":[90],"fraction)":[94,101],"III":[96,139],"(20":[97],"groups.":[102],"Rats":[103],"induced":[105],"with":[106],"high":[107],"cholesterol":[108,158],"saturated":[110],"fat":[111],"feeds":[112],"28":[114,128],"days,":[115],"except":[116],"group.":[120],"Furthermore,":[121],"rats":[122],"given":[124],"treatment":[126],"days.":[129],"The":[130,181],"results":[131],"showed":[132],"when":[133],"compared":[134],"than":[135],"control,":[137],"reduced":[140,166],"total":[142,157,167],"cholesterol,":[143,168],"triglycerides,":[144],"LDL":[145,160,171],"levels":[146,161,172,179],"increased":[148],"HDL":[149,178],"level":[150],"(p":[151],"<0.05).":[152],"Dose":[153],"could":[155],"reduce":[156],"(p<0,05),":[162],"whereas":[163],"triglycerides":[169],"(p<0,05)":[173],"but":[174],"did":[175],"not":[176],"increase":[177],"(p>0,05).":[180],"conclusion":[182],"at":[192],"20":[193],"bb":[196],"had":[198],"best":[200],"antihiperlipidemic":[201],"effect.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}