{"id":"https://openalex.org/W1685398392","doi":null,"title":"From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster","display_name":"From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1685398392","mag":"1685398392"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:2c874f4b-7874-45fe-9974-4950061c2292","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1221290","pdf_url":"https://lup.lub.lu.se/record/1221290","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/1221290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035642792","display_name":"Shai Mulinari","orcid":"https://orcid.org/0000-0001-8773-9796","observed_orcids":["https://orcid.org/0000-0001-8773-9796"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shai Mulinari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8773-9796","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035642792"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.20730000734329224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-morphogenesis","display_name":"epithelial morphogenesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/rho1","display_name":"Rho1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/diaphanous","display_name":"Diaphanous","score":0.7879999876022339},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7910000085830688},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.7509999871253967},{"id":"https://openalex.org/keywords/rgs-domain","display_name":"RGS domain","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/crumbs","display_name":"Crumbs","score":0.9760000109672546},{"id":"https://openalex.org/keywords/enabled","display_name":"Enabled","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.8192169070243835},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7933275699615479},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.7306962013244629},{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.7285202741622925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7025166749954224},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.6575175523757935},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5788857936859131},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5360581874847412},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.5089168548583984},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4977703392505646},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.485792875289917},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.4748556613922119},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4672030806541443},{"id":"https://openalex.org/C2909331102","wikidata":"https://www.wikidata.org/wiki/Q7278834","display_name":"Rac GTP-Binding Proteins","level":4,"score":0.45810508728027344},{"id":"https://openalex.org/C39579648","wikidata":"https://www.wikidata.org/wiki/Q4779796","display_name":"Apical constriction","level":4,"score":0.45459914207458496},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.4370940923690796},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24968159198760986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24162724614143372},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23722082376480103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07729145884513855}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lup.lub.lu.se:2c874f4b-7874-45fe-9974-4950061c2292","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1221290","pdf_url":"https://lup.lub.lu.se/record/1221290","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1685398392","doi":null,"is_oa":false,"landing_page_url":"http://lup.lub.lu.se/search/ws/files/3532543/1222555.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:2c874f4b-7874-45fe-9974-4950061c2292","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1221290","pdf_url":"https://lup.lub.lu.se/record/1221290","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1685398392.pdf","grobid_xml":"https://content.openalex.org/works/W1685398392.grobid-xml"},"referenced_works_count":287,"referenced_works":["https://openalex.org/W15778579","https://openalex.org/W16508796","https://openalex.org/W27862169","https://openalex.org/W639502040","https://openalex.org/W1490646520","https://openalex.org/W1506197483","https://openalex.org/W1509485250","https://openalex.org/W1527650585","https://openalex.org/W1535427487","https://openalex.org/W1543362511","https://openalex.org/W1560387541","https://openalex.org/W1566432282","https://openalex.org/W1571632059","https://openalex.org/W1574397195","https://openalex.org/W1583486328","https://openalex.org/W1596316114","https://openalex.org/W1772563489","https://openalex.org/W1781095925","https://openalex.org/W1816187765","https://openalex.org/W1869366780","https://openalex.org/W1880648489","https://openalex.org/W1881600462","https://openalex.org/W1883406310","https://openalex.org/W1889767892","https://openalex.org/W1900991908","https://openalex.org/W1912436781","https://openalex.org/W1938204331","https://openalex.org/W1951020172","https://openalex.org/W1964359283","https://openalex.org/W1965090975","https://openalex.org/W1966530523","https://openalex.org/W1967328078","https://openalex.org/W1968162244","https://openalex.org/W1968981755","https://openalex.org/W1969714257","https://openalex.org/W1971646616","https://openalex.org/W1973149624","https://openalex.org/W1973535514","https://openalex.org/W1973738379","https://openalex.org/W1975304898","https://openalex.org/W1977084276","https://openalex.org/W1977831337","https://openalex.org/W1979040385","https://openalex.org/W1979366429","https://openalex.org/W1979521848","https://openalex.org/W1979825058","https://openalex.org/W1980719358","https://openalex.org/W1980821707","https://openalex.org/W1981184799","https://openalex.org/W1984374880","https://openalex.org/W1984491329","https://openalex.org/W1984875632","https://openalex.org/W1987476111","https://openalex.org/W1989825101","https://openalex.org/W1989966395","https://openalex.org/W1990850141","https://openalex.org/W1991583928","https://openalex.org/W1991722684","https://openalex.org/W1991984207","https://openalex.org/W1992191014","https://openalex.org/W1993735775","https://openalex.org/W1994139415","https://openalex.org/W1994396897","https://openalex.org/W1994528729","https://openalex.org/W1994746388","https://openalex.org/W1995054229","https://openalex.org/W1995619799","https://openalex.org/W1995757732","https://openalex.org/W1996736225","https://openalex.org/W1997087774","https://openalex.org/W1997505974","https://openalex.org/W1997698479","https://openalex.org/W1997889647","https://openalex.org/W1998888750","https://openalex.org/W2000092886","https://openalex.org/W2000572318","https://openalex.org/W2001779234","https://openalex.org/W2001953889","https://openalex.org/W2002085601","https://openalex.org/W2002964349","https://openalex.org/W2006216712","https://openalex.org/W2007554905","https://openalex.org/W2007660746","https://openalex.org/W2008555242","https://openalex.org/W2009359492","https://openalex.org/W2009441114","https://openalex.org/W2009843711","https://openalex.org/W2011343310","https://openalex.org/W2011684758","https://openalex.org/W2011751979","https://openalex.org/W2013394636","https://openalex.org/W2013576879","https://openalex.org/W2014154406","https://openalex.org/W2016450222","https://openalex.org/W2016636976","https://openalex.org/W2016901222","https://openalex.org/W2017485209","https://openalex.org/W2018659688","https://openalex.org/W2018823276","https://openalex.org/W2019562739","https://openalex.org/W2019710908","https://openalex.org/W2019731805","https://openalex.org/W2021374902","https://openalex.org/W2021541131","https://openalex.org/W2022723700","https://openalex.org/W2023687572","https://openalex.org/W2023915893","https://openalex.org/W2026339935","https://openalex.org/W2027067842","https://openalex.org/W2027513993","https://openalex.org/W2027608016","https://openalex.org/W2027717266","https://openalex.org/W2027754350","https://openalex.org/W2027810531","https://openalex.org/W2027919192","https://openalex.org/W2028154752","https://openalex.org/W2028774330","https://openalex.org/W2029475325","https://openalex.org/W2030023587","https://openalex.org/W2030255198","https://openalex.org/W2030945799","https://openalex.org/W2032295238","https://openalex.org/W2033799675","https://openalex.org/W2034536549","https://openalex.org/W2034935332","https://openalex.org/W2038333370","https://openalex.org/W2038443908","https://openalex.org/W2038585541","https://openalex.org/W2039799168","https://openalex.org/W2040261458","https://openalex.org/W2040683778","https://openalex.org/W2041904579","https://openalex.org/W2042917833","https://openalex.org/W2045860277","https://openalex.org/W2047040065","https://openalex.org/W2048887608","https://openalex.org/W2048967061","https://openalex.org/W2049425193","https://openalex.org/W2050867644","https://openalex.org/W2051657877","https://openalex.org/W2052190647","https://openalex.org/W2053320483","https://openalex.org/W2053912448","https://openalex.org/W2054379658","https://openalex.org/W2054821269","https://openalex.org/W2055466007","https://openalex.org/W2056922353","https://openalex.org/W2057120350","https://openalex.org/W2058170014","https://openalex.org/W2058549159","https://openalex.org/W2059400753","https://openalex.org/W2060046714","https://openalex.org/W2061413580","https://openalex.org/W2061577820","https://openalex.org/W2062235108","https://openalex.org/W2062890130","https://openalex.org/W2063575573","https://openalex.org/W2064021058","https://openalex.org/W2064171951","https://openalex.org/W2064387879","https://openalex.org/W2067209613","https://openalex.org/W2067577192","https://openalex.org/W2068423840","https://openalex.org/W2070119451","https://openalex.org/W2072400772","https://openalex.org/W2072768871","https://openalex.org/W2072976264","https://openalex.org/W2073033206","https://openalex.org/W2073346616","https://openalex.org/W2073356925","https://openalex.org/W2076324043","https://openalex.org/W2077603983","https://openalex.org/W2079337167","https://openalex.org/W2079626024","https://openalex.org/W2080098793","https://openalex.org/W2082988779","https://openalex.org/W2083758347","https://openalex.org/W2085730270","https://openalex.org/W2086204346","https://openalex.org/W2086768044","https://openalex.org/W2087471158","https://openalex.org/W2087654007","https://openalex.org/W2089208780","https://openalex.org/W2089472706","https://openalex.org/W2091154399","https://openalex.org/W2092245168","https://openalex.org/W2093226717","https://openalex.org/W2093723806","https://openalex.org/W2093968022","https://openalex.org/W2094735120","https://openalex.org/W2095013577","https://openalex.org/W2096335633","https://openalex.org/W2096720319","https://openalex.org/W2096791952","https://openalex.org/W2097028894","https://openalex.org/W2097131990","https://openalex.org/W2098204492","https://openalex.org/W2098996804","https://openalex.org/W2099429692","https://openalex.org/W2099887793","https://openalex.org/W2101173100","https://openalex.org/W2102010710","https://openalex.org/W2102312968","https://openalex.org/W2102836127","https://openalex.org/W2103080800","https://openalex.org/W2105746559","https://openalex.org/W2107973236","https://openalex.org/W2108465436","https://openalex.org/W2110643873","https://openalex.org/W2110767317","https://openalex.org/W2110898138","https://openalex.org/W2111481536","https://openalex.org/W2111785219","https://openalex.org/W2112630320","https://openalex.org/W2112634792","https://openalex.org/W2113179909","https://openalex.org/W2114649122","https://openalex.org/W2116052541","https://openalex.org/W2116463110","https://openalex.org/W2117384649","https://openalex.org/W2119009024","https://openalex.org/W2120613121","https://openalex.org/W2122087650","https://openalex.org/W2123475580","https://openalex.org/W2123912198","https://openalex.org/W2125545718","https://openalex.org/W2125615720","https://openalex.org/W2126496496","https://openalex.org/W2127587858","https://openalex.org/W2127735672","https://openalex.org/W2128601880","https://openalex.org/W2128680169","https://openalex.org/W2129890878","https://openalex.org/W2131545216","https://openalex.org/W2132665664","https://openalex.org/W2134073082","https://openalex.org/W2134597119","https://openalex.org/W2134603143","https://openalex.org/W2134699117","https://openalex.org/W2136032801","https://openalex.org/W2136556113","https://openalex.org/W2136812809","https://openalex.org/W2136906483","https://openalex.org/W2139582633","https://openalex.org/W2141652419","https://openalex.org/W2142941757","https://openalex.org/W2143254725","https://openalex.org/W2144554951","https://openalex.org/W2144614846","https://openalex.org/W2145367033","https://openalex.org/W2146318623","https://openalex.org/W2146473598","https://openalex.org/W2147677686","https://openalex.org/W2148450224","https://openalex.org/W2152462023","https://openalex.org/W2154328299","https://openalex.org/W2154655439","https://openalex.org/W2156549182","https://openalex.org/W2156999424","https://openalex.org/W2157934217","https://openalex.org/W2158092584","https://openalex.org/W2159922116","https://openalex.org/W2160419242","https://openalex.org/W2160571369","https://openalex.org/W2161287639","https://openalex.org/W2161685517","https://openalex.org/W2161872209","https://openalex.org/W2163709364","https://openalex.org/W2163752836","https://openalex.org/W2166519728","https://openalex.org/W2167324829","https://openalex.org/W2168137103","https://openalex.org/W2169478707","https://openalex.org/W2170996392","https://openalex.org/W2182106443","https://openalex.org/W2182475970","https://openalex.org/W2187872339","https://openalex.org/W2189480951","https://openalex.org/W2241520519","https://openalex.org/W2284894778","https://openalex.org/W2325421187","https://openalex.org/W2336490348","https://openalex.org/W2343698626","https://openalex.org/W2346651568","https://openalex.org/W2410493236","https://openalex.org/W4242342141","https://openalex.org/W7096389801"],"related_works":["https://openalex.org/W2136556113","https://openalex.org/W2154001959","https://openalex.org/W2027067842","https://openalex.org/W7100323725","https://openalex.org/W2161287639","https://openalex.org/W2505125987","https://openalex.org/W2577194985","https://openalex.org/W2031317001","https://openalex.org/W2034935332","https://openalex.org/W2097028894"],"abstract_inverted_index":{"Embryonic":[0],"development":[1],"is":[2,15,76,179],"associated":[3,180],"with":[4,181],"extensive":[5],"rearrangements":[6,14],"of":[7,21,25,62,70,80,106,134,145,161,183,212,224,246,257,282,286,294],"tissues.":[8],"The":[9,51],"driving":[10],"force":[11],"for":[12,156,240,309,344],"these":[13],"generated":[16],"by":[17,37,66],"a":[18,94,104,112,154,217,321],"dynamic":[19],"reorganization":[20],"the":[22,55,63,71,77,81,118,132,146,159,173,184,203,210,222,227,280,283,300,317,329,353],"Actin":[23,135,265,354],"cytoskeleton":[24,355],"individual":[26],"cells.":[27],"In":[28,91,149,199,275],"many":[29],"instances,":[30],"conserved":[31],"Rho-family":[32],"GTPases":[33],"that":[34,57,170,194,207,250,262,299,337,348,363],"are":[35,165,238,306,342,350],"activated":[36],"Rho":[38],"guanine":[39],"nucleotide":[40],"exchange":[41],"factors":[42],"(RhoGEFs)":[43],"play":[44,127],"an":[45,99,128],"important":[46,129],"role":[47,130,155,223,323],"in":[48,117,131,158,172,231,324,328],"this":[49,150,232],"process.":[50,233],"present":[52],"thesis":[53],"investigates":[54],"mechanisms":[56],"control":[58],"activation":[59,370],"and":[60,88,111,143,189,191,215,226,236,252,303,340],"specificity":[61,366],"GTPase":[64],"Rho1":[65,358],"DRhoGEF2":[67,75,97,122,157,225,235,251,268,326,339,364],"during":[68,137,175,371],"morphogenesis":[69,160,346],"Drosophila":[72,78],"embryonic":[73],"epidermis.":[74],"ortholog":[79],"human":[82],"RhoGEFs,":[83],"LARG":[84],"(Leukemia-associated":[85],"RhoGEF),":[86],"PDZ-RhoGEF":[87],"p115":[89],"RhoGEFs.":[90],"addition":[92],"to":[93,126,209,220,277,352,367],"catalytic":[95],"module,":[96],"encompasses":[98],"N-terminal":[100],"PSD-95/Dlg/ZO-1":[101],"(PDZ)":[102],"domain,":[103],"Regulator":[105],"G-protein":[107],"Signaling":[108],"(RGS)":[109],"domain":[110,116],"cysteine-rich":[113],"diacylglycerol":[114],"(DAG)-binding":[115],"central":[119],"region.":[120],"Previously,":[121],"has":[123],"been":[124],"shown":[125],"constriction":[133],"filaments":[136,266],"pole":[138],"cell":[139,204],"formation,":[140],"blastoderm":[141],"cellularization,":[142],"invagination":[144],"germ":[147],"layers.":[148],"thesis,":[151],"we":[152,192,201,288],"describe":[153,202],"segmental":[162,213],"grooves,":[163,214],"which":[164],"segmentally":[166],"repeated":[167],"tissue":[168],"infoldings":[169],"form":[171],"epidermis":[174],"mid-embryogenesis.":[176],"Groove":[177],"formation":[178,211],"up-regulation":[182],"groove":[185,241,345],"cell-markers":[186],"odd-skipped,":[187],"crumbs":[188],"enabled,":[190],"demonstrate":[193],"Hh-signaling":[195],"promotes":[196],"their":[197,247],"accumulation.":[198],"addition,":[200],"shape":[205],"changes":[206],"lead":[208],"take":[216],"genetic":[218],"approach":[219],"characterize":[221],"Rho1-effector":[228,368],"Diaphanous":[229],"(Dia)":[230],"Both":[234],"dia":[237],"required":[239,343],"formation.":[242],"However,":[243],"detailed":[244],"analysis":[245],"function":[248],"suggests":[249],"Dia":[253,263,341],"regulate":[254],"different":[255,284],"aspects":[256],"cytoskeletal":[258],"reorganization.":[259],"We":[260,361],"find":[261],"polymerizes":[264],"whereas":[267],"regulates":[269],"F-Actin":[270],"contraction":[271],"but":[272,347],"not":[273,307],"polymerization.":[274],"order":[276],"functionally":[278],"dissect":[279],"roles":[281],"domains":[285,305],"DRhoGEF2,":[287],"have":[289,320],"created":[290],"several":[291],"truncated":[292],"forms":[293],"DRhoGEF2.":[295],"Expression":[296],"studies":[297],"suggest":[298,336],"PDZ,":[301],"RGS":[302],"DAG":[304],"essential":[308],"protein":[310],"activity":[311],"or":[312],"constitutive":[313],"membrane":[314],"targeting,":[315],"although":[316],"PDZ-domain":[318],"may":[319],"specific":[322],"mediating":[325],"localization":[327],"early":[330],"embryo.":[331],"Taken":[332],"together":[333],"our":[334],"data":[335],"both":[338],"they":[349],"connected":[351],"through":[356],"distinct":[357],"effector":[359],"pathways.":[360],"hypothesize":[362],"provides":[365],"pathway":[369],"epithelial":[372],"morphogenesis.":[373]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
