{"id":"https://openalex.org/W168539731","doi":null,"title":"Overview of docetaxel (Taxotere)/cisplatin combination in non-small cell lung cancer.","display_name":"Overview of docetaxel (Taxotere)/cisplatin combination in non-small cell lung cancer.","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W168539731","mag":"168539731","pmid":"https://pubmed.ncbi.nlm.nih.gov/10458205"},"language":"en","primary_location":{"id":"pmid:10458205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10458205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111449926","display_name":"Thierry Le Chevalier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T Le Chevalier","raw_affiliation_strings":["Department of Medicine, Institut Gustave-Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Gustave-Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088697715","display_name":"Jocelyne B\u00e9rille","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B\u00e9rille","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008173055","display_name":"John Raymond Zalcberg","orcid":"https://orcid.org/0000-0002-6624-0782","observed_orcids":["https://orcid.org/0000-0002-6624-0782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Zalcberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079833339","display_name":"Michael Millward","orcid":"https://orcid.org/0000-0002-1744-1617","observed_orcids":["https://orcid.org/0000-0002-1744-1617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Millward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102815230","display_name":"Alain Monnier","orcid":"https://orcid.org/0000-0002-3674-3899","observed_orcids":["https://orcid.org/0000-0002-3674-3899"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Monnier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114777958","display_name":"Jean\u2010Yves Douillard","orcid":"https://orcid.org/0000-0002-6540-7333","observed_orcids":["https://orcid.org/0000-0002-6540-7333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Y Douillard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038498358","display_name":"Mark James McKeage","orcid":"https://orcid.org/0000-0002-7329-5503","observed_orcids":["https://orcid.org/0000-0002-7329-5503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J McKeage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040609777","display_name":"F. Soulas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Soulas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040653552","display_name":"Camille Loret","orcid":"https://orcid.org/0009-0005-4969-0705","observed_orcids":["https://orcid.org/0009-0005-4969-0705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Loret","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065114519","display_name":"Nathalie Bougon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Bougon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110082107","display_name":"Jean-Pierre Bizzari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Bizzari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.311,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80481377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"3 Suppl 11","first_page":"13","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.2345000058412552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5490000247955322},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/treatment-schedule","display_name":"treatment schedule","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9644110202789307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9193839430809021},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6934232711791992},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6933825016021729},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6271436214447021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6054031252861023},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5929805636405945},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.582192063331604},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.5771393179893494},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4330364465713501},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4325329065322876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4163866341114044},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37397295236587524},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37122657895088196},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.17037877440452576},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10458205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10458205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.atira.dk:publications/24036a09-af94-4725-8d25-f5d193429d49","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/overview-of-doectaxel-taxoterecisplatin-combination-in-nonsmall-cell-lung-cancer(24036a09-af94-4725-8d25-f5d193429d49).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Millward, M 1999, 'Overview of doectaxel (Taxotere)/cisplatin combination in non-small cell lung cancer', Seminars in Oncology, pp. 13-18.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:168539731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10458205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995582426","https://openalex.org/W2079171343","https://openalex.org/W2242033023","https://openalex.org/W2072912486","https://openalex.org/W1982198648","https://openalex.org/W2993920066","https://openalex.org/W1967730248","https://openalex.org/W2260145618","https://openalex.org/W2061161363","https://openalex.org/W2149463127"],"abstract_inverted_index":{"Cisplatin-based":[0],"chemotherapy":[1],"is":[2,23,233],"effective":[3],"in":[4,40,47,51,129,135,181,189,214,239,247],"non-small":[5],"cell":[6],"lung":[7],"cancer":[8],"(NSCLC),":[9],"although":[10],"it":[11],"prolongs":[12],"survival":[13,154,162],"only":[14],"modestly.":[15],"Single-agent":[16],"docetaxel":[17,60,78],"(Taxotere;":[18],"Rh\u00f4ne-Poulenc":[19],"Rorer,":[20],"Antony,":[21],"France)":[22],"highly":[24],"active":[25],"against":[26],"NSCLC.":[27,252],"The":[28,103],"activity":[29],"and":[30,49,133,208,216,236],"tolerability":[31],"of":[32,105,141,164,168,183,193,219,242,250],"two":[33,41,197,230],"docetaxel/":[34],"cisplatin":[35,67,85],"regimens":[36],"were":[37,114,121,176,203],"therefore":[38],"investigated":[39],"multicenter":[42],"phase":[43],"II":[44],"studies,":[45],"one":[46,50,171],"Australia":[48],"France.":[52],"Chemotherapy-naive":[53],"patients":[54,113,132,136],"with":[55,137,146,159,205],"inoperable":[56],"NSCLC":[57],"received":[58],"either":[59],"75":[61,68,79],"mg/m2":[62,69,80,87],"on":[63,81],"day":[64,82],"1":[65,83],"plus":[66,84],"3":[70,89],"weekly":[71],"(n":[72,98],"=":[73,99],"47;":[74],"Australian":[75],"study)":[76],"or":[77],"100":[86],"every":[88,95],"weeks":[90,97],"for":[91,116],"three":[92],"cycles":[93,175],"then":[94],"6":[96,144],"51;":[100],"French":[101],"study).":[102],"majority":[104],"the":[106,240,243,248],"population":[107],"(74%)":[108],"had":[109],"metastatic":[110],"disease.":[111],"Seventy-eight":[112],"evaluable":[115,131],"efficacy.":[117],"Overall":[118],"response":[119,142],"rates":[120],"36%":[122],"(95%":[123],"confidence":[124],"interval,":[125],"25":[126],"to":[127,151,172,196],"47)":[128],"all":[130],"34%":[134],"metastases.":[138],"Median":[139,153],"duration":[140],"was":[143,156],"months,":[145,158],"a":[147,160],"4-month":[148],"median":[149,167],"time":[150,155],"progression.":[152],"9":[157],"1-year":[161],"rate":[163],"34%.":[165],"A":[166],"four":[169],"(range,":[170],"nine)":[173],"treatment":[174,249],"administered.":[177],"Febrile":[178],"neutropenia":[179],"occurred":[180,188],"14%":[182],"patients.":[184,221],"Severe":[185],"infection,":[186],"which":[187],"less":[190],"than":[191],"7%":[192],"patients,":[194],"led":[195],"toxic":[198],"deaths.":[199],"Other":[200],"severe":[201,206,209,223],"toxicities":[202],"rare,":[204],"stomatitis":[207],"neurosensory":[210],"side":[211],"effects":[212],"reported":[213],"2%":[215],"1%,":[217],"respectively,":[218],"treated":[220],"No":[222],"fluid":[224],"retention":[225],"occurred.":[226],"Docetaxel/cisplatin,":[227],"administered":[228],"as":[229],"different":[231],"schedules,":[232],"well":[234],"tolerated":[235],"exhibits":[237],"efficacy":[238],"range":[241],"most":[244],"established":[245],"combinations":[246],"advanced":[251]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}