{"id":"https://openalex.org/W168508276","doi":null,"title":"PPARs. Receptores activados por proliferadores peroxisomales","display_name":"PPARs. Receptores activados por proliferadores peroxisomales","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W168508276","mag":"168508276"},"language":"es","primary_location":{"id":"pmh:oai:redalyc.org:564261749006","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=564261749006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de nefrolog\u00eda, di\u00e1lisis y transplante (Argentina) Num.2 Vol.29","raw_type":"art\u00edculo cient\u00edfico"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://biblat.unam.mx/hevila/Revistadenefrologiadialisisytransplante/2009/vol29/no2/5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045981209","display_name":"Hugo Zelechower","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugo Zelechower","raw_affiliation_strings":["Centro de Enfermedades Renales e Hipertensi\u00f3n Arterial, , Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Enfermedades Renales e Hipertensi\u00f3n Arterial, , Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058953429","display_name":"Alicia Ester Elbert","orcid":"https://orcid.org/0000-0003-1993-9328","observed_orcids":["https://orcid.org/0000-0003-1993-9328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alicia Esther Elbert","raw_affiliation_strings":["Centro de Enfermedades Renales e Hipertensi\u00f3n Arterial, , Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Enfermedades Renales e Hipertensi\u00f3n Arterial, , Buenos Aires, Argentina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"2","first_page":"74","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nuclear-receptor-superfamily","display_name":"nuclear receptor superfamily","score":0.8259999752044678},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7210000157356262},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7110000252723694},{"id":"https://openalex.org/keywords/fibrates","display_name":"fibrates","score":0.515999972820282},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ppar-agonists","display_name":"PPAR agonists","score":0.6100000143051147},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.42899999022483826},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6359999775886536},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6600000262260437},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.5720000267028809},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4970000088214874},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8999999761581421},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5698328018188477},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.45216500759124756},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.16369867324829102}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:redalyc.org:564261749006","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=564261749006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de nefrolog\u00eda, di\u00e1lisis y transplante (Argentina) Num.2 Vol.29","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:168508276","doi":null,"is_oa":true,"landing_page_url":"https://biblat.unam.mx/hevila/Revistadenefrologiadialisisytransplante/2009/vol29/no2/5.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1038894675","display_name":"Revista De Nefrologia Dialisis Y Trasplante","issn_l":"0326-3428","issn":["0326-3428"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","nbra","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista De Nefrologia Dialisis Y Trasplante","raw_type":null}],"best_oa_location":{"id":"mag:168508276","doi":null,"is_oa":true,"landing_page_url":"https://biblat.unam.mx/hevila/Revistadenefrologiadialisisytransplante/2009/vol29/no2/5.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1038894675","display_name":"Revista De Nefrologia Dialisis Y Trasplante","issn_l":"0326-3428","issn":["0326-3428"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","nbra","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista De Nefrologia Dialisis Y Trasplante","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1488559297","https://openalex.org/W1561779083","https://openalex.org/W1608005125","https://openalex.org/W1639924204","https://openalex.org/W1647126819","https://openalex.org/W1675830194","https://openalex.org/W1812285428","https://openalex.org/W1968637251","https://openalex.org/W1971213885","https://openalex.org/W1972190403","https://openalex.org/W1973436528","https://openalex.org/W1974139741","https://openalex.org/W1974654697","https://openalex.org/W1977041568","https://openalex.org/W1982027543","https://openalex.org/W1983864692","https://openalex.org/W1985709687","https://openalex.org/W1990641914","https://openalex.org/W2003918929","https://openalex.org/W2006013310","https://openalex.org/W2008048680","https://openalex.org/W2008589779","https://openalex.org/W2009285473","https://openalex.org/W2017671227","https://openalex.org/W2018160773","https://openalex.org/W2018198144","https://openalex.org/W2018781081","https://openalex.org/W2020079510","https://openalex.org/W2024254257","https://openalex.org/W2027980802","https://openalex.org/W2034542419","https://openalex.org/W2034618205","https://openalex.org/W2042058415","https://openalex.org/W2042706232","https://openalex.org/W2042881415","https://openalex.org/W2043076331","https://openalex.org/W2047687800","https://openalex.org/W2048748448","https://openalex.org/W2055123644","https://openalex.org/W2055726721","https://openalex.org/W2078535741","https://openalex.org/W2082432305","https://openalex.org/W2082460839","https://openalex.org/W2088233968","https://openalex.org/W2090497124","https://openalex.org/W2094809211","https://openalex.org/W2099262759","https://openalex.org/W2102034544","https://openalex.org/W2102634499","https://openalex.org/W2102666508","https://openalex.org/W2104224178","https://openalex.org/W2104875047","https://openalex.org/W2106127329","https://openalex.org/W2108018829","https://openalex.org/W2110866952","https://openalex.org/W2115414014","https://openalex.org/W2128557965","https://openalex.org/W2128712342","https://openalex.org/W2133690273","https://openalex.org/W2135330586","https://openalex.org/W2140792307","https://openalex.org/W2146901298","https://openalex.org/W2147084771","https://openalex.org/W2148718682","https://openalex.org/W2151625863","https://openalex.org/W2157920676","https://openalex.org/W2159270178","https://openalex.org/W2161324995","https://openalex.org/W2166280318","https://openalex.org/W2170353692","https://openalex.org/W2198678228","https://openalex.org/W2223757933","https://openalex.org/W2397303011"],"related_works":["https://openalex.org/W2183626917","https://openalex.org/W2916586261","https://openalex.org/W2256040884","https://openalex.org/W6986419598","https://openalex.org/W7061216124","https://openalex.org/W1822103383","https://openalex.org/W2460734832","https://openalex.org/W2049227087","https://openalex.org/W2082460839","https://openalex.org/W2733082442"],"abstract_inverted_index":{"\"Los":[0],"PPARS":[1],"receptores":[2,21],"de":[3,5,8,13,19,41,43,81,92,99,110,125,155,159,161,179,215,218],"activaci\u00f3n":[4,71],"los":[6,9,20,36,82,108,141,145,186],"proliferadores":[7],"peroxisomas":[10],"son":[11,198],"factores":[12],"transcripci\u00f3n":[14],"pertenecientes":[15],"a":[16,79,153],"la":[17,51,57,64,100,103,123,134,180,213,216,221],"superfamilia":[18],"nucleares.":[22],"Existen":[23],"tres":[24],"subtipos":[25],"PPAR,":[26],"PPAR":[27,194,196],"/":[28],"y":[29,66,89,102,131,152,188,195,204,224],"PPAR.":[30],"Se":[31],"encuentran":[32],"distribuidos":[33],"en":[34,50,56,59,63,72,107,122,133,140,168,171,201],"todos":[35],"tejidos":[37],"con":[38,119,173,177],"alta":[39],"actividad":[40],"catabolismo":[42],"\u00e1cidos":[44],"grasos,":[45],"incluyendo":[46],"el":[47,60,67,73,96,113],"ri\u00f1\u00f3n.":[48],"Participan":[49],"regulaci\u00f3n":[52],"del":[53,128],"metabolismo":[54,61],"lip\u00eddico,":[55],"adipogenesis,":[58],"glucidico,":[62],"inflamaci\u00f3n":[65],"tono":[68],"vascular.":[69],"La":[70],"ri\u00f1\u00f3n":[74],"por":[75],"agonistas":[76,193],"ex\u00f3genos":[77],"especialmente":[78,106],"nivel":[80],"PPARs":[83],"provoca":[84],"un":[85],"efecto":[86],"antiproliferativo,":[87],"antifibr\u00f3tico":[88],"antinflamatorio":[90],"pudiendo":[91],"esta":[93],"forma":[94],"modificar":[95],"curso":[97],"progresivo":[98],"glomeruloesclerosis":[101],"fibrosis":[104],"tubulointersticial":[105],"estados":[109],"hiperglucemia.":[111],"En":[112],"humano":[114],"sus":[115],"efectos":[116,146],"se":[117],"traducen":[118],"una":[120],"disminuci\u00f3n":[121],"excreci\u00f3n":[124],"alb\u00famina,":[126],"atenuaci\u00f3n":[127],"da\u00f1o":[129],"renal":[130],"mejor\u00eda":[132],"funci\u00f3n.":[135],"Sin":[136],"embargo":[137],"su":[138],"presencia":[139],"t\u00fabulo":[142],"colectores":[143],"favorece":[144],"colaterales":[147],"como":[148,176,185,190,212,220],"retenci\u00f3n":[149],"h\u00eddrica,":[150],"edemas":[151],"consecuencia":[154],"estos":[156],"efectos,":[157],"aumento":[158],"riesgo":[160],"insuficiencia":[162],"cardiaca":[163],"lo":[164],"que":[165],"debe":[166],"tenerse":[167],"cuenta":[169],"tanto":[170],"pacientes":[172],"proteinuria":[174],"severa":[175],"deterioro":[178],"funci\u00f3n":[181],"renal.":[182],"Drogas":[183],"hipolipemiantes":[184],"fibratos":[187],"antihiperglucemiantes":[189],"las":[191,208],"tiazoledinedionas":[192],"respectivamente":[197],"actualmente":[199],"utilizadas":[200],"nuestro":[202],"medio":[203],"han":[205],"permitido":[206],"ampliar":[207],"posibilidades":[209],"terap\u00e9uticas,":[210],"as\u00ed":[211],"comprensi\u00f3n":[214],"fisiopatolog\u00eda":[217],"enfermedades":[219],"diabetes,":[222],"obesidad":[223],"s\u00edndrome":[225],"metab\u00f3lico.\"":[226]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}