{"id":"https://openalex.org/W1684521871","doi":null,"title":"Pharmaco- and therapygenetic aspects in the treatment of anxiety disorders beyond the serotonergic system: a brief review.","display_name":"Pharmaco- and therapygenetic aspects in the treatment of anxiety disorders beyond the serotonergic system: a brief review.","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1684521871","mag":"1684521871","pmid":"https://pubmed.ncbi.nlm.nih.gov/23269208"},"language":"en","primary_location":{"id":"pmid:23269208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://real.mtak.hu/26445/1/faludi_web%281%29.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110908833","display_name":"G\u00e1bor Faludi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gabor Faludi","raw_affiliation_strings":["Department of Clinical and Theoretical Mental Health, K\u00fatv\u00f6lgyi Clinical Center, Semmelweis University, 1125 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Theoretical Mental Health, K\u00fatv\u00f6lgyi Clinical Center, Semmelweis University, 1125 Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030182773","display_name":"X\u00e9nia Gonda","orcid":"https://orcid.org/0000-0001-9015-4203","observed_orcids":["https://orcid.org/0000-0001-9015-4203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xenia Gonda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011181373","display_name":"Gy\u00f6rgy Bagdy","orcid":"https://orcid.org/0000-0001-8141-3410","observed_orcids":["https://orcid.org/0000-0001-8141-3410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gyorgy Bagdy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053181230","display_name":"P\u00e9ter D\u00f6me","orcid":"https://orcid.org/0000-0003-3847-0553","observed_orcids":["https://orcid.org/0000-0003-3847-0553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Dome","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4316,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.51912987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"4","first_page":"221","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1768999993801117,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.968999981880188},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":1.0},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.7210000157356262},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7881645560264587},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.7873885631561279},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.683859646320343},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.6775783896446228},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5575060844421387},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4911958873271942},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4884602129459381},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.44344812631607056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3994711637496948},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3719249367713928},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3315211832523346},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25626468658447266},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.217260479927063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16326072812080383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1600140929222107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1474115252494812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1360856294631958},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11285090446472168},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08854135870933533}],"mesh":[{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008995","descriptor_name":"Monoamine Oxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018490","descriptor_name":"Serotonin Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050580","descriptor_name":"Excitatory Amino Acid Transporter 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:23269208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:26445","doi":null,"is_oa":true,"landing_page_url":"http://real.mtak.hu/26445/1/faludi_web%281%29.pdf","pdf_url":"http://real.mtak.hu/26445/1/faludi_web%281%29.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1684521871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:real.mtak.hu:26445","doi":null,"is_oa":true,"landing_page_url":"http://real.mtak.hu/26445/1/faludi_web%281%29.pdf","pdf_url":"http://real.mtak.hu/26445/1/faludi_web%281%29.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G679077284","display_name":null,"funder_award_id":"OTKA 80289","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"}],"funders":[{"id":"https://openalex.org/F4320321102","display_name":"Semmelweis Egyetem","ror":"https://ror.org/01g9ty582"},{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1684521871.pdf","grobid_xml":"https://content.openalex.org/works/W1684521871.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W146116948","https://openalex.org/W1987838528","https://openalex.org/W1998261300","https://openalex.org/W2007139949","https://openalex.org/W2021002624","https://openalex.org/W2022816995","https://openalex.org/W2028688777","https://openalex.org/W2045078990","https://openalex.org/W2055560477","https://openalex.org/W2078775644","https://openalex.org/W2099136954","https://openalex.org/W2100903632","https://openalex.org/W2102454290","https://openalex.org/W2105963198","https://openalex.org/W2108783879","https://openalex.org/W2115352662","https://openalex.org/W2139718449","https://openalex.org/W2141671502","https://openalex.org/W2143133280","https://openalex.org/W2148830430","https://openalex.org/W2171871035","https://openalex.org/W2413833701"],"related_works":["https://openalex.org/W7033131170","https://openalex.org/W4210971771","https://openalex.org/W2969455648","https://openalex.org/W3205656207","https://openalex.org/W1987838528","https://openalex.org/W4377939672","https://openalex.org/W619132242","https://openalex.org/W4240174359","https://openalex.org/W2038109950","https://openalex.org/W2148830430"],"abstract_inverted_index":{"Anxiety":[0],"disorders":[1,24,47,142],"(ADs)":[2],"are":[3,19],"among":[4,20],"the":[5,21,38,43,51,76,82,105,127,134,144],"most":[6],"frequent":[7],"psychiatric":[8],"disorders.":[9,131],"In":[10,99],"addition,":[11],"key":[12],"features":[13],"of":[14,40,45,54,65,78,86,96,129,140],"ADs":[15,68],"include":[16],"that":[17,28],"they":[18],"earliest":[22],"mental":[23],"to":[25,56,94,126],"manifest":[26],"and":[27,84,116,121],"their":[29,122],"first":[30],"specific":[31],"treatment":[32,64],"frequently":[33],"occurs":[34],"several":[35],"years":[36],"after":[37],"onset":[39],"symptoms.":[41],"Although":[42],"heritability":[44],"anxiety":[46,87,130,141],"is":[48,69],"well":[49],"known,":[50],"genetic":[52],"determination":[53],"response":[55],"different":[57],"modalities":[58],"(psycho-":[59],"or":[60],"pharmacotherapy)":[61],"used":[62],"in":[63,81],"patients":[66],"with":[67,124],"lesser":[70],"investigated.":[71],"Several":[72],"studies":[73],"focused":[74],"on":[75,104,137],"role":[77],"serotonergic":[79,145],"genes":[80],"etiopathology":[83],"pharmacotherapy":[85],"disorders,":[88],"however,":[89],"less":[90],"attention":[91],"was":[92],"paid":[93],"variants":[95],"other":[97],"genes.":[98],"this":[100],"review":[101],"we":[102],"focus":[103],"cytochrome":[106],"P":[107],"450,":[108],"BDNF,":[109],"COMT,":[110],"MAOA,":[111],"EAA-3":[112],"transporter,":[113],"dopamine":[114,117],"transporter":[115],"receptor":[118],"gene":[119],"polymorphisms":[120],"effects":[123],"respect":[125],"pharmacogenetics":[128],"We":[132],"discuss":[133],"current":[135],"knowledge":[136],"pharmacogenetic/therapygenetic":[138],"aspects":[139],"beyond":[143],"system.":[146]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}