{"id":"https://openalex.org/W168127828","doi":null,"title":"Differential Effects of Ventricular Pacing Sites of Contraction Synchrony and Global Cardiac Performance.","display_name":"Differential Effects of Ventricular Pacing Sites of Contraction Synchrony and Global Cardiac Performance.","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W168127828","mag":"168127828","pmid":"https://pubmed.ncbi.nlm.nih.gov/21949483"},"language":"en","primary_location":{"id":"pmid:21949483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21949483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care and shock","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178394","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007580923","display_name":"Mohammed T. Alhammouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Alhammouri","raw_affiliation_strings":["Cardiopulmonary Research Laboratory, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiopulmonary Research Laboratory, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070314469","display_name":"Hyung-Kook Kim","orcid":"https://orcid.org/0000-0003-4974-5233","observed_orcids":["https://orcid.org/0000-0003-4974-5233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyung Kook Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006212923","display_name":"Yasser M. Mokhtar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasser Mokhtar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081001020","display_name":"Maxime P. Cannesson","orcid":"https://orcid.org/0000-0003-2120-1672","observed_orcids":["https://orcid.org/0000-0003-2120-1672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maxime Cannesson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765771","display_name":"Masaki Tanabe","orcid":"https://orcid.org/0009-0009-9626-6332","observed_orcids":["https://orcid.org/0009-0009-9626-6332","https://orcid.org/0000-0002-6398-5965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki Tanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101805912","display_name":"John Gorcsan","orcid":"https://orcid.org/0000-0001-9360-1005","observed_orcids":["https://orcid.org/0000-0001-9360-1005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Gorcsan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074822733","display_name":"DAVID S. SCHWARTZMAN","orcid":"https://orcid.org/0000-0002-0362-8333","observed_orcids":["https://orcid.org/0000-0002-0362-8333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Schwartzman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053558278","display_name":"Michael R. Pinsky","orcid":"https://orcid.org/0000-0001-6166-700X","observed_orcids":["https://orcid.org/0000-0001-6166-700X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R Pinsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01699045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-dyssynchrony","display_name":"left ventricular dyssynchrony","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"cardiac resynchronization therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/left-ventricular-pacing-site","display_name":"left ventricular pacing site","score":0.7279999852180481},{"id":"https://openalex.org/keywords/fusion-beats","display_name":"fusion beats","score":0.7039999961853027},{"id":"https://openalex.org/keywords/left-bundle-branch-block","display_name":"left bundle branch block","score":0.8659999966621399},{"id":"https://openalex.org/keywords/radial-strain","display_name":"radial strain","score":0.5289999842643738},{"id":"https://openalex.org/keywords/stroke-work","display_name":"stroke work","score":0.8199999928474426},{"id":"https://openalex.org/keywords/end-diastolic-volume","display_name":"end-diastolic volume","score":0.7630000114440918},{"id":"https://openalex.org/keywords/end-systolic-elastance","display_name":"end-systolic elastance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/esmolol","display_name":"esmolol","score":0.6850000023841858},{"id":"https://openalex.org/keywords/av-node-ablation","display_name":"AV node ablation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.5189999938011169},{"id":"https://openalex.org/keywords/pressure-volume-loops","display_name":"pressure-volume loops","score":0.6579999923706055},{"id":"https://openalex.org/keywords/left-ventricular-contractility","display_name":"left ventricular contractility","score":0.5429999828338623},{"id":"https://openalex.org/keywords/right-ventricular-pacing","display_name":"right ventricular pacing","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7868641018867493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7430354952812195},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.6589380502700806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.620127260684967},{"id":"https://openalex.org/C39078644","wikidata":"https://www.wikidata.org/wiki/Q17092725","display_name":"Isovolumetric contraction","level":4,"score":0.5466691255569458},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5141187310218811},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4439215064048767},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.41347506642341614},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.33864420652389526},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2948377728462219},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.22717049717903137}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:21949483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21949483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care and shock","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3178394","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178394","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Crit Care Shock","raw_type":"Text"},{"id":"mag:168127828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21949483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3178394","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178394","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Crit Care Shock","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G28083472","display_name":"Cardiac Performance by Quantitative Echocardiography","funder_award_id":"5k24hl004503-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4727352339","display_name":"Heart-Lung Interactions & Cardiovascular Insufficiency","funder_award_id":"K24HL067181","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5742872705","display_name":"Quantifying Left Ventricular Ejection Effectiveness","funder_award_id":"5r01hl073198-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1783024460","https://openalex.org/W1964501573","https://openalex.org/W1970505034","https://openalex.org/W1980210973","https://openalex.org/W1992989476","https://openalex.org/W1998637784","https://openalex.org/W2004148522","https://openalex.org/W2015007614","https://openalex.org/W2015697923","https://openalex.org/W2019251974","https://openalex.org/W2039282828","https://openalex.org/W2040475917","https://openalex.org/W2046184359","https://openalex.org/W2052275339","https://openalex.org/W2053866991","https://openalex.org/W2062478509","https://openalex.org/W2082266963","https://openalex.org/W2084138982","https://openalex.org/W2092453673","https://openalex.org/W2104097982","https://openalex.org/W2107805895","https://openalex.org/W2130907431","https://openalex.org/W2131607419","https://openalex.org/W2145293134","https://openalex.org/W2164030561","https://openalex.org/W2164824243","https://openalex.org/W2174803350","https://openalex.org/W2183695425","https://openalex.org/W2567948445","https://openalex.org/W3139601660"],"related_works":["https://openalex.org/W2283498498","https://openalex.org/W3040030292","https://openalex.org/W2914416650","https://openalex.org/W2120586973","https://openalex.org/W185849997","https://openalex.org/W1970505034","https://openalex.org/W2271640573","https://openalex.org/W2781968935","https://openalex.org/W2116840181","https://openalex.org/W2744779588","https://openalex.org/W3029772175","https://openalex.org/W1993924731","https://openalex.org/W2062266670","https://openalex.org/W2399228408","https://openalex.org/W2284100198","https://openalex.org/W2001435929","https://openalex.org/W2114454911","https://openalex.org/W2548724630","https://openalex.org/W3151844747","https://openalex.org/W3029651669"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quantification":[1],"of":[2,11,22,40,56,69,110,265],"left":[3,70],"ventricular":[4,62,140],"(LV)":[5],"dyssynchrony":[6,174,190],"allows":[7],"for":[8,123,137],"objective":[9],"measures":[10,39],"resynchronization":[12],"therapy":[13],"(CRT)":[14],"effectiveness.":[15],"We":[16],"tested":[17],"the":[18,54,263,275,318],"hypothesis":[19],"that":[20],"site":[21],"LV":[23,41,85,90,94,167,232,301,313,319],"pacing,":[24],"fusion":[25,142],"beats":[26],"and":[27,37,83,87,101,104,131,139,170,204,207,218,245,278,291],"baseline":[28,285],"contractility":[29,249],"alter":[30,262],"contraction":[31,74,281,294],"synchrony":[32],"as":[33,66,92],"quantified":[34],"by":[35,304],"regional":[36],"global":[38,300,312],"performance.":[42],"METHODS":[43],"AND":[44],"RESULTS:":[45],"In":[46],"8":[47],"open-chested":[48],"pentobarbital-anesthetized":[49],"canine":[50],"preparations":[51],"we":[52],"compared":[53],"effects":[55],"right":[57,61],"atrial":[58],"(RA),":[59],"RA-high":[60],"(RV)":[63],"free":[64,80,279],"wall,":[65],"a":[67],"model":[68],"bundle":[71],"branch":[72],"block":[73],"pattern,":[75],"RA-LV":[76,79],"apex":[77],"(LVa),":[78],"wall":[81,89,280],"(LVfw),":[82],"RA-RV-apical":[84],"(CRTa)":[86],"RA-RV-free":[88],"(CRTfw),":[91],"CRT.":[93],"pressure-volume":[95],"loops":[96],"recorded":[97],"using":[98],"high-fidelity":[99],"pressure":[100],"conductance":[102],"catheters":[103],"echocardiographic":[105],"angle-corrected":[106],"color-coded":[107],"strain":[108,117],"imaging":[109],"mid-LV":[111],"short":[112],"axis":[113],"views":[114],"analyzed":[115],"radial":[116,173,189],"from":[118,182,240,253],"six":[119],"segments.":[120],"To":[121],"control":[122,136],"contractile":[124],"state":[125],"esmolol-induced":[126],"beta":[127],"blockage":[128],"was":[129],"studied,":[130],"in":[132,188,195],"5":[133],"dogs":[134],"to":[135,160,184,230,242,247,255,298],"RA":[138,164],"pacing":[141,154,320],"beat":[143],"artifacts,":[144],"repeat":[145],"studies":[146],"were":[147],"done":[148],"following":[149],"AV":[150,269],"node":[151],"ablation.":[152],"RA-RV":[153],"reduced":[155,293],"stroke":[156],"work":[157],"(SW)":[158],"(57\u00b118":[159],"33\u00b113*":[161],"mmHg\u00b7mL,*p<0.05":[162],"vs":[163,224],"pacing),":[165],"decreased":[166],"end-diastolic":[168,233,306],"volume":[169,234],"induced":[171,267],"marked":[172],"(maximal":[175],"time":[176],"difference":[177],"between":[178],"peak":[179],"segmental":[180],"strain)":[181],"31\u00b115":[183],"234\u00b160*":[185],"ms.":[186],"Changes":[187],"correlated":[191],"significantly":[192],"with":[193,201,215],"changes":[194],"SW":[196,212],"(r=-0.53,":[197],"p<0.01).":[198],"Dyssynchrony":[199],"improved":[200,214],"both":[202,289],"CRTa":[203,216,227,290,296],"CRTfw":[205,292],"(69*\u00b131":[206],"98*\u00b163":[208],"ms,":[209],"respectively)":[210],"while":[211],"only":[213],"(62\u00b122*":[217],"37\u00b113":[219],"mmHg\u00b7mL,":[220],"respectively":[221],"*":[222],"p<0.05":[223],"RV":[225],"pacing).":[226],"also":[228],"tended":[229,246,297],"increased":[231],"over":[235],"RA-RV.":[236],"Esmolol":[237],"slowed":[238],"HR":[239],"118\u00b110":[241],"108\u00b110":[243],"beats/min*":[244],"decrease":[248],"(end-systolic":[250],"elastance":[251],"(Ees)":[252],"12.1\u00b17.9":[254],"8.9\u00b13.9":[256],"mmHg/ml,":[257],"p=0.167)":[258],"but":[259],"did":[260],"not":[261],"degree":[264],"RV-pacing":[266],"dyssynchrony.":[268],"ablation":[270],"had":[271],"no":[272],"effect":[273],"on":[274,317],"observed":[276],"apical":[277],"differences":[282],"seen":[283],"during":[284],"conditions.":[286],"CONCLUSION:":[287],"Although":[288],"dyssynchrony,":[295],"improve":[299,311],"performance":[302,314],"more":[303],"increasing":[305],"volume.":[307],"Thus,":[308],"CRT":[309],"may":[310],"differently,":[315],"depending":[316],"site.":[321]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
