{"id":"https://openalex.org/W168095317","doi":null,"title":"Serum-free cell growth and differentiation studies in cultured cell lines","display_name":"Serum-free cell growth and differentiation studies in cultured cell lines","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W168095317","mag":"168095317"},"language":"en","primary_location":{"id":"pmh:oai:doras.dcu.ie:19072","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0001-5306-310X>","pdf_url":"https://doras.dcu.ie/19072/1/Paula_Meleady_20130617143956.pdf","source":{"id":"https://openalex.org/S4306401511","display_name":"Dublin City University Open Access Institutional Repository (Dublin City University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I42934936","host_organization_name":"Dublin City University","host_organization_lineage":["https://openalex.org/I42934936"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doras.dcu.ie/19072/1/Paula_Meleady_20130617143956.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018053019","display_name":"Paula Meleady","orcid":"https://orcid.org/0000-0001-5306-310X","observed_orcids":["https://orcid.org/0000-0001-5306-310X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paula Meleady","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018053019"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-free-medium","display_name":"serum-free medium","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cho-k1-cells","display_name":"CHO-K1 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5059999823570251},{"id":"https://openalex.org/keywords/bromodeoxyuridine","display_name":"bromodeoxyuridine","score":0.968999981880188},{"id":"https://openalex.org/keywords/integrin-expression","display_name":"integrin expression","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7360000014305115},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/keratin-19","display_name":"keratin 19","score":0.9089999794960022},{"id":"https://openalex.org/keywords/epithelial-specific-antigen","display_name":"epithelial-specific antigen","score":0.7749999761581421},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/microcarrier-culture","display_name":"microcarrier culture","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.7745635509490967},{"id":"https://openalex.org/C176999471","wikidata":"https://www.wikidata.org/wiki/Q6839314","display_name":"Microcarrier","level":3,"score":0.6356561183929443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6052778363227844},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5673776865005493},{"id":"https://openalex.org/C2778260397","wikidata":"https://www.wikidata.org/wiki/Q419861","display_name":"Bromodeoxyuridine","level":3,"score":0.5327890515327454},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5216060876846313},{"id":"https://openalex.org/C98648569","wikidata":"https://www.wikidata.org/wiki/Q5090513","display_name":"Chemically defined medium","level":3,"score":0.4767780601978302},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4431607723236084},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42156508564949036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3786069452762604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22198596596717834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20736515522003174},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19289645552635193}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doras.dcu.ie:19072","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0001-5306-310X>","pdf_url":"https://doras.dcu.ie/19072/1/Paula_Meleady_20130617143956.pdf","source":{"id":"https://openalex.org/S4306401511","display_name":"Dublin City University Open Access Institutional Repository (Dublin City University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I42934936","host_organization_name":"Dublin City University","host_organization_lineage":["https://openalex.org/I42934936"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:http://www.rian.ie/63880/","doi":null,"is_oa":false,"landing_page_url":"http://doras.dcu.ie/19072/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Meleady, Paula (1997) Serum-free cell growth and differentiation studies in cultured cell lines. PhD thesis, Dublin City University.","raw_type":"Other"},{"id":"mag:168095317","doi":null,"is_oa":false,"landing_page_url":"http://doras.dcu.ie/19072/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:doras.dcu.ie:19072","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0001-5306-310X>","pdf_url":"https://doras.dcu.ie/19072/1/Paula_Meleady_20130617143956.pdf","source":{"id":"https://openalex.org/S4306401511","display_name":"Dublin City University Open Access Institutional Repository (Dublin City University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I42934936","host_organization_name":"Dublin City University","host_organization_lineage":["https://openalex.org/I42934936"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W168095317.pdf","grobid_xml":"https://content.openalex.org/works/W168095317.grobid-xml"},"referenced_works_count":350,"referenced_works":["https://openalex.org/W35496378","https://openalex.org/W54479471","https://openalex.org/W57799326","https://openalex.org/W70976387","https://openalex.org/W103200536","https://openalex.org/W109871772","https://openalex.org/W139815902","https://openalex.org/W152105768","https://openalex.org/W158811859","https://openalex.org/W162671065","https://openalex.org/W168157626","https://openalex.org/W177037658","https://openalex.org/W207060544","https://openalex.org/W1021857115","https://openalex.org/W1487570186","https://openalex.org/W1491249957","https://openalex.org/W1499261244","https://openalex.org/W1514170807","https://openalex.org/W1525170202","https://openalex.org/W1537459781","https://openalex.org/W1543755962","https://openalex.org/W1548939686","https://openalex.org/W1550107681","https://openalex.org/W1551479053","https://openalex.org/W1552100503","https://openalex.org/W1560983656","https://openalex.org/W1561806714","https://openalex.org/W1561921347","https://openalex.org/W1563613529","https://openalex.org/W1566157726","https://openalex.org/W1576502615","https://openalex.org/W1576833897","https://openalex.org/W1577998113","https://openalex.org/W1586828155","https://openalex.org/W1588352407","https://openalex.org/W1588546890","https://openalex.org/W1592869430","https://openalex.org/W1593129117","https://openalex.org/W1595383321","https://openalex.org/W1596419992","https://openalex.org/W1634520049","https://openalex.org/W1636159574","https://openalex.org/W1659287181","https://openalex.org/W1683261118","https://openalex.org/W1756091829","https://openalex.org/W1764824114","https://openalex.org/W1773256867","https://openalex.org/W1817269218","https://openalex.org/W1831734000","https://openalex.org/W1834622832","https://openalex.org/W1857381743","https://openalex.org/W1892608609","https://openalex.org/W1894641937","https://openalex.org/W1902133227","https://openalex.org/W1910121302","https://openalex.org/W1948774306","https://openalex.org/W1966205706","https://openalex.org/W1966286149","https://openalex.org/W1966590430","https://openalex.org/W1966748740","https://openalex.org/W1967106371","https://openalex.org/W1967756702","https://openalex.org/W1968131914","https://openalex.org/W1968490536","https://openalex.org/W1969240457","https://openalex.org/W1969699638","https://openalex.org/W1971895756","https://openalex.org/W1971929854","https://openalex.org/W1972917027","https://openalex.org/W1973064020","https://openalex.org/W1974827896","https://openalex.org/W1975569947","https://openalex.org/W1975718597","https://openalex.org/W1976500073","https://openalex.org/W1977677834","https://openalex.org/W1977860453","https://openalex.org/W1978178803","https://openalex.org/W1978609854","https://openalex.org/W1979146509","https://openalex.org/W1979211697","https://openalex.org/W1981254630","https://openalex.org/W1981752846","https://openalex.org/W1982150634","https://openalex.org/W1982336436","https://openalex.org/W1982412787","https://openalex.org/W1983867148","https://openalex.org/W1984918376","https://openalex.org/W1985176515","https://openalex.org/W1985350651","https://openalex.org/W1986707414","https://openalex.org/W1986849497","https://openalex.org/W1987132278","https://openalex.org/W1987751737","https://openalex.org/W1988078820","https://openalex.org/W1988284469","https://openalex.org/W1988614006","https://openalex.org/W1989780564","https://openalex.org/W1989963027","https://openalex.org/W1990737205","https://openalex.org/W1990795810","https://openalex.org/W1991629297","https://openalex.org/W1991644963","https://openalex.org/W1991923853","https://openalex.org/W1992269368","https://openalex.org/W1993126462","https://openalex.org/W1994825180","https://openalex.org/W1995096983","https://openalex.org/W1995548246","https://openalex.org/W1996550186","https://openalex.org/W1996600132","https://openalex.org/W1998111985","https://openalex.org/W1998284666","https://openalex.org/W1998554766","https://openalex.org/W1999060144","https://openalex.org/W1999918470","https://openalex.org/W2000808409","https://openalex.org/W2001753204","https://openalex.org/W2002005540","https://openalex.org/W2002673703","https://openalex.org/W2003298005","https://openalex.org/W2003381363","https://openalex.org/W2003387801","https://openalex.org/W2003942374","https://openalex.org/W2004452061","https://openalex.org/W2006298308","https://openalex.org/W2006477962","https://openalex.org/W2006772665","https://openalex.org/W2006920207","https://openalex.org/W2007660746","https://openalex.org/W2007826986","https://openalex.org/W2009669935","https://openalex.org/W2010147791","https://openalex.org/W2010307195","https://openalex.org/W2010414816","https://openalex.org/W2010943308","https://openalex.org/W2011761081","https://openalex.org/W2012870447","https://openalex.org/W2013103674","https://openalex.org/W2013381560","https://openalex.org/W2013756363","https://openalex.org/W2014113076","https://openalex.org/W2014230003","https://openalex.org/W2014236276","https://openalex.org/W2015696916","https://openalex.org/W2015872305","https://openalex.org/W2016693266","https://openalex.org/W2018629910","https://openalex.org/W2019177713","https://openalex.org/W2019364665","https://openalex.org/W2019405807","https://openalex.org/W2020372308","https://openalex.org/W2020974043","https://openalex.org/W2020981270","https://openalex.org/W2021206045","https://openalex.org/W2021802757","https://openalex.org/W2023342066","https://openalex.org/W2023549361","https://openalex.org/W2023800215","https://openalex.org/W2025247732","https://openalex.org/W2025566127","https://openalex.org/W2026151657","https://openalex.org/W2026327508","https://openalex.org/W2028134580","https://openalex.org/W2028793859","https://openalex.org/W2029428231","https://openalex.org/W2029675195","https://openalex.org/W2029714766","https://openalex.org/W2029977444","https://openalex.org/W2030957900","https://openalex.org/W2031749514","https://openalex.org/W2032556368","https://openalex.org/W2033458658","https://openalex.org/W2034185792","https://openalex.org/W2034541018","https://openalex.org/W2034782293","https://openalex.org/W2035252564","https://openalex.org/W2036268248","https://openalex.org/W2036953698","https://openalex.org/W2038112114","https://openalex.org/W2038154593","https://openalex.org/W2038609878","https://openalex.org/W2038769267","https://openalex.org/W2039317622","https://openalex.org/W2039574630","https://openalex.org/W2040588681","https://openalex.org/W2041150657","https://openalex.org/W2045944156","https://openalex.org/W2046383553","https://openalex.org/W2046386827","https://openalex.org/W2046938785","https://openalex.org/W2049130091","https://openalex.org/W2051319640","https://openalex.org/W2053387982","https://openalex.org/W2053413980","https://openalex.org/W2054779757","https://openalex.org/W2054942641","https://openalex.org/W2055070696","https://openalex.org/W2055085109","https://openalex.org/W2055145919","https://openalex.org/W2056041200","https://openalex.org/W2057409901","https://openalex.org/W2058217397","https://openalex.org/W2059219497","https://openalex.org/W2059425014","https://openalex.org/W2060042326","https://openalex.org/W2060666524","https://openalex.org/W2060832558","https://openalex.org/W2061385217","https://openalex.org/W2061599748","https://openalex.org/W2061949093","https://openalex.org/W2062042301","https://openalex.org/W2062375210","https://openalex.org/W2063599502","https://openalex.org/W2064892849","https://openalex.org/W2065386076","https://openalex.org/W2066109395","https://openalex.org/W2066367871","https://openalex.org/W2067199247","https://openalex.org/W2067801563","https://openalex.org/W2068124694","https://openalex.org/W2068421187","https://openalex.org/W2068499309","https://openalex.org/W2069810305","https://openalex.org/W2069810321","https://openalex.org/W2070556283","https://openalex.org/W2073167560","https://openalex.org/W2073506505","https://openalex.org/W2073651193","https://openalex.org/W2074525890","https://openalex.org/W2075639507","https://openalex.org/W2075657173","https://openalex.org/W2075911358","https://openalex.org/W2076263039","https://openalex.org/W2076926300","https://openalex.org/W2076980438","https://openalex.org/W2078297328","https://openalex.org/W2078517933","https://openalex.org/W2078976125","https://openalex.org/W2079228197","https://openalex.org/W2079777908","https://openalex.org/W2080000569","https://openalex.org/W2080034804","https://openalex.org/W2080118074","https://openalex.org/W2080395294","https://openalex.org/W2080404084","https://openalex.org/W2080497558","https://openalex.org/W2081401313","https://openalex.org/W2081923886","https://openalex.org/W2083361243","https://openalex.org/W2084411307","https://openalex.org/W2084675552","https://openalex.org/W2085804760","https://openalex.org/W2086487142","https://openalex.org/W2086578539","https://openalex.org/W2086803868","https://openalex.org/W2086865079","https://openalex.org/W2087129197","https://openalex.org/W2089425094","https://openalex.org/W2089594248","https://openalex.org/W2091300510","https://openalex.org/W2091351880","https://openalex.org/W2091463575","https://openalex.org/W2091583322","https://openalex.org/W2091761175","https://openalex.org/W2092642041","https://openalex.org/W2093386691","https://openalex.org/W2094351112","https://openalex.org/W2094825203","https://openalex.org/W2094845268","https://openalex.org/W2096133301","https://openalex.org/W2097878215","https://openalex.org/W2098102805","https://openalex.org/W2099666051","https://openalex.org/W2099955838","https://openalex.org/W2102126511","https://openalex.org/W2103262956","https://openalex.org/W2105500381","https://openalex.org/W2106221695","https://openalex.org/W2106929134","https://openalex.org/W2108360007","https://openalex.org/W2109449392","https://openalex.org/W2109790916","https://openalex.org/W2112549882","https://openalex.org/W2116136455","https://openalex.org/W2119297613","https://openalex.org/W2119888383","https://openalex.org/W2120518688","https://openalex.org/W2121206386","https://openalex.org/W2121383876","https://openalex.org/W2122081319","https://openalex.org/W2124136616","https://openalex.org/W2129510413","https://openalex.org/W2132122851","https://openalex.org/W2132864109","https://openalex.org/W2133323445","https://openalex.org/W2135121318","https://openalex.org/W2135544311","https://openalex.org/W2140444852","https://openalex.org/W2141728368","https://openalex.org/W2141739327","https://openalex.org/W2142291651","https://openalex.org/W2142575037","https://openalex.org/W2142909451","https://openalex.org/W2145278635","https://openalex.org/W2150211095","https://openalex.org/W2153042760","https://openalex.org/W2154326390","https://openalex.org/W2154796814","https://openalex.org/W2155619649","https://openalex.org/W2158920155","https://openalex.org/W2159352345","https://openalex.org/W2161242427","https://openalex.org/W2161438752","https://openalex.org/W2163304270","https://openalex.org/W2166452296","https://openalex.org/W2167302014","https://openalex.org/W2167850151","https://openalex.org/W2168269500","https://openalex.org/W2172160601","https://openalex.org/W2181349295","https://openalex.org/W2188472662","https://openalex.org/W2215348743","https://openalex.org/W2278014922","https://openalex.org/W2300151603","https://openalex.org/W2328583280","https://openalex.org/W2339772503","https://openalex.org/W2346505852","https://openalex.org/W2397175625","https://openalex.org/W2397516586","https://openalex.org/W2399679254","https://openalex.org/W2400076052","https://openalex.org/W2404649686","https://openalex.org/W2404958475","https://openalex.org/W2408916117","https://openalex.org/W2411222285","https://openalex.org/W2411249859","https://openalex.org/W2412282397","https://openalex.org/W2413825876","https://openalex.org/W2413870682","https://openalex.org/W2416649560","https://openalex.org/W2419644505","https://openalex.org/W2427118866","https://openalex.org/W2431673242","https://openalex.org/W2431760751","https://openalex.org/W2437010695","https://openalex.org/W2461936985","https://openalex.org/W2466809917","https://openalex.org/W2479037221","https://openalex.org/W3142144633","https://openalex.org/W4255876385"],"related_works":["https://openalex.org/W6908536482","https://openalex.org/W2444239613","https://openalex.org/W2010508856","https://openalex.org/W151728571","https://openalex.org/W602344504","https://openalex.org/W3161153160","https://openalex.org/W1970902196","https://openalex.org/W4403790723","https://openalex.org/W3029312895","https://openalex.org/W1981899137"],"abstract_inverted_index":{"The":[0,93,140,272],"thesis":[1],"is":[2,87],"divided":[3],"into":[4,20],"two":[5,177],"main":[6],"sections":[7],"investigating":[8],"growth":[9,51,101,121,141,173],"and":[10,111,122,203,245,289,291,339],"differentiation":[11],"in":[12,44,69,84,104,112,148,160,185,205,240,255,262,311,354],"cultured":[13,43],"cell":[14,35,40,129,133,197,215,359],"lines.":[15],"Investigations":[16],"were":[17,96,208],"carried":[18,210],"out":[19,211],"the":[21,28,32,39,67,81,85,120,144,161,165,170,175,194,227,231,234,241,263,266,283,309,315,323,355,371,384],"establishment":[22],"of":[23,31,99,102,124,143,154,158,167,174,193,226,230,243,247,265,300,314,318,325,328,346,373],"serum-free":[24,149],"media":[25,115],"(SFM)":[26],"for":[27,119],"long-term":[29,91],"subcultivation":[30],"industrially":[33],"important":[34],"line,":[36,130,198,360],"CHO-K1.":[37],"When":[38],"line":[41,134,216],"was":[42,52,76,116,199,217,258,351],"a":[45,70,125,188,222,259,326],"high":[46],"calcium":[47,72,82],"containing":[48],"medium,":[49,73],"cellular":[50,336],"found":[53],"to":[54,59,89,169,282,292,296,305,381],"be":[55,182,382],"inhibited":[56],"after":[57,362],"4":[58],"6":[60],"passages":[61],"on":[62,212,375],"average.":[63],"However,":[64,164],"by":[65],"growing":[66],"cells":[68,232,267,273,307,320],"low":[71],"continuous":[74],"cultivation":[75],"possible.":[77],"It":[78],"appears":[79,380],"that":[80,370],"concentration":[83],"SFM":[86,94,171],"critical":[88],"this":[90,253],"growth.":[92],"developed":[95,118,274],"also":[97,117,200,209,321,352],"capable":[98,157],"supporting":[100],"CHO-K1":[103],"suspension":[105],"culture":[106],"with":[107,151,233,252,269],"Pluronic":[108],"F68":[109],"supplementation":[110],"microcarrier":[113],"culture.\\n\\nSerum-free":[114],"sub-cultivation":[123],"human":[126,356],"lung":[127,357],"cancer":[128],"DLKP.":[131,213],"This":[132,214],"contains":[135],"three":[136,145],"morphologically":[137],"distinct":[138],"subpopulations.":[139],"pattern":[142],"clones":[146],"differed":[147],"medium":[150],"only":[152],"one":[153],"them,":[155],"DLKP-I,":[156],"proliferating":[159],"above":[162],"medium.":[163],"addition":[166],"fibronectin":[168],"permitted":[172],"other":[176],"clones.":[178],"All":[179],"sub-populations":[180],"could":[181],"subcultured":[183,204],"indefinitely":[184],"SFM.":[186],"DLKP-A,":[187],"multiple":[189],"drug":[190],"resistant":[191],"variant":[192],"parental":[195],"DLKP":[196,319],"successfully":[201],"grown":[202],"SFM.\\n\\nDifferentiation":[206],"studies":[207],"originally":[218],"histologically":[219],"diagnosed":[220],"as":[221],"\u2018poorly":[223],"differentiated":[224],"carcinoma":[225],"lung\u2019.":[228],"Treatment":[229],"differentiation-inducing":[235],"agent,":[236],"5-bromodeoxyuridine":[237],"(BrdU)":[238],"resulted":[239],"induction":[242],"integrin":[244,249,256],"upregulation":[246,345],"a2p,":[248],"expression.":[250],"Associated":[251],"change":[254,261],"expression":[257,324,350,379],"functional":[260],"properties":[264,277,313],"themselves":[268],"BrdU":[270,363,374],"treatment.":[271,364],"different":[275],"adhesive":[276,312],"showing":[278],"more":[279],"rapid":[280],"attachment":[281],"extracellular":[284],"matrix":[285],"proteins,":[286],"collagen,":[287],"laminin":[288],"fibronectin,":[290],"basement":[293],"membrane":[294],"compared":[295],"untreated":[297],"cells.":[298],"Addition":[299],"an":[301],"anti-integrin":[302],"blocking":[303],"antibody":[304],"BrdU-treated":[306],"reversed":[308],"changes":[310],"cells.\\n\\nBrdU":[316],"treatment":[317],"induced":[322],"number":[327],"epithelial":[329,332],"antigens,":[330],"including":[331],"specific":[333],"antigen":[334],"(a":[335],"adhesion":[337],"molecule)":[338],"keratin":[340,347,376],"19":[341,348,377],"filaments.":[342],"A":[343],"significant":[344],"protein":[349],"observed":[353],"adenocarcinoma":[358],"A549,":[361],"Preliminary":[365],"RT-PCR":[366],"analysis":[367],"has":[368],"shown":[369],"effect":[372],"mRNA":[378],"at":[383],"post-transcriptional/":[385],"translational":[386],"level.":[387]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
