{"id":"https://openalex.org/W1679729595","doi":"https://doi.org/10.4049/jimmunol.164.5.2550","title":"An Upstream Oct-1- and Oct-2-Binding Silencer Governs B29 (Ig\u03b2) Gene Expression","display_name":"An Upstream Oct-1- and Oct-2-Binding Silencer Governs B29 (Ig\u03b2) Gene Expression","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W1679729595","doi":"https://doi.org/10.4049/jimmunol.164.5.2550","mag":"1679729595","pmid":"https://pubmed.ncbi.nlm.nih.gov/10679093"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.164.5.2550","doi":"https://doi.org/10.4049/jimmunol.164.5.2550","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.164.5.2550","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/164/5/2550/1315812/2550.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/164/5/2550/1315812/2550.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011370023","display_name":"Cindy Sue Malone","orcid":"https://orcid.org/0000-0002-1607-2768","observed_orcids":["https://orcid.org/0000-0002-1607-2768"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Sue Malone","raw_affiliation_strings":["Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine , Los Angeles, CA 90095","*Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine, Los Angeles, CA 90095; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine , Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"*Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine, Los Angeles, CA 90095; and","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052416325","display_name":"Lisa Patrone","orcid":"https://orcid.org/0000-0002-9515-7785","observed_orcids":["https://orcid.org/0000-0002-9515-7785"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lisa Patrone","raw_affiliation_strings":["Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine , Los Angeles, CA 90095","*Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine, Los Angeles, CA 90095; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine , Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"*Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine, Los Angeles, CA 90095; and","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079898826","display_name":"Kent L. Buchanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent L Buchanan","raw_affiliation_strings":["\u2020Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077439703","display_name":"Carol F. Webb","orcid":"https://orcid.org/0000-0003-4164-9634","observed_orcids":["https://orcid.org/0000-0003-4164-9634"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol F Webb","raw_affiliation_strings":["\u2020Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111499055","display_name":"Randolph Wall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randolph Wall","raw_affiliation_strings":["Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine , Los Angeles, CA 90095","*Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine, Los Angeles, CA 90095; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine , Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"*Department of Microbiology and Immunology, and Molecular Biology Institute, University of California, School of Medicine, Los Angeles, CA 90095; and","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052416325","https://openalex.org/A5111499055"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.3237,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.78279902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"164","issue":"5","first_page":"2550","last_page":"2556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-silencer","display_name":"transcriptional silencer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oct-1","display_name":"Oct-1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oct-2","display_name":"Oct-2","score":1.0},{"id":"https://openalex.org/keywords/at-rich-sequences","display_name":"AT-rich sequences","score":0.8960000276565552},{"id":"https://openalex.org/keywords/matrix-attachment-regions","display_name":"matrix attachment regions","score":0.875},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C190414344","wikidata":"https://www.wikidata.org/wiki/Q1781769","display_name":"Silencer","level":3,"score":0.8836073875427246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6819806098937988},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.591506838798523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5330832004547119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.529853343963623},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4539177715778351},{"id":"https://openalex.org/C173681060","wikidata":"https://www.wikidata.org/wiki/Q5773169","display_name":"Histone octamer","level":5,"score":0.45068448781967163},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.41102635860443115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24514204263687134},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.06625783443450928},{"id":"https://openalex.org/C201289731","wikidata":"https://www.wikidata.org/wiki/Q1172599","display_name":"Inlet","level":2,"score":0.0},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015530","descriptor_name":"Nuclear Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015530","descriptor_name":"Nuclear Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051925","descriptor_name":"CD79 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.164.5.2550","doi":"https://doi.org/10.4049/jimmunol.164.5.2550","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.164.5.2550","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/164/5/2550/1315812/2550.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10679093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10679093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.133.3066","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.133.3066","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.csun.edu/~cmalone/pdfpubs/JI2000.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.164.5.2550","doi":"https://doi.org/10.4049/jimmunol.164.5.2550","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.164.5.2550","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/164/5/2550/1315812/2550.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1441259545","display_name":null,"funder_award_id":"GM-40185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3484517225","display_name":"Control of Lymphocyte Development","funder_award_id":"R01GM040185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G759011626","display_name":null,"funder_award_id":"CA-12800","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8077810100","display_name":"IMMUNE FUNCTIONS AND CANCER","funder_award_id":"5p01ca012800-24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8569267054","display_name":null,"funder_award_id":"GM46462","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1679729595.pdf","grobid_xml":"https://content.openalex.org/works/W1679729595.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W26755955","https://openalex.org/W39451727","https://openalex.org/W121534735","https://openalex.org/W122353466","https://openalex.org/W280078261","https://openalex.org/W1591452120","https://openalex.org/W1605917342","https://openalex.org/W1780970321","https://openalex.org/W1789989063","https://openalex.org/W1843347371","https://openalex.org/W1950899769","https://openalex.org/W1963841005","https://openalex.org/W1965168691","https://openalex.org/W1970139633","https://openalex.org/W1971102416","https://openalex.org/W1974369867","https://openalex.org/W1975299127","https://openalex.org/W1999131239","https://openalex.org/W2004215286","https://openalex.org/W2011859878","https://openalex.org/W2013064216","https://openalex.org/W2017860616","https://openalex.org/W2021170422","https://openalex.org/W2021598200","https://openalex.org/W2030629446","https://openalex.org/W2038218774","https://openalex.org/W2052988833","https://openalex.org/W2053572117","https://openalex.org/W2057212851","https://openalex.org/W2057893650","https://openalex.org/W2062676684","https://openalex.org/W2063756403","https://openalex.org/W2063775625","https://openalex.org/W2069949654","https://openalex.org/W2070499185","https://openalex.org/W2071289292","https://openalex.org/W2074544607","https://openalex.org/W2074596664","https://openalex.org/W2089298476","https://openalex.org/W2090326746","https://openalex.org/W2106960031","https://openalex.org/W2112591674","https://openalex.org/W2118299921","https://openalex.org/W2133690652","https://openalex.org/W2136050321","https://openalex.org/W2140989915","https://openalex.org/W2148347504","https://openalex.org/W2159348779","https://openalex.org/W2166901872","https://openalex.org/W2170891925","https://openalex.org/W2171373646","https://openalex.org/W2177704086","https://openalex.org/W2220955715","https://openalex.org/W2416006368","https://openalex.org/W2417301380","https://openalex.org/W4247769440"],"related_works":["https://openalex.org/W2070499185","https://openalex.org/W1971102416","https://openalex.org/W1494050952","https://openalex.org/W1975299127","https://openalex.org/W1580850944","https://openalex.org/W1983666965","https://openalex.org/W2008836328","https://openalex.org/W2083609595","https://openalex.org/W7099410084","https://openalex.org/W2086487557"],"abstract_inverted_index":{"The":[0],"B":[1,11,18,32,211],"cell-specific":[2,33],"B29":[3,26,61,73,80,121,151,154,183],"(Igbeta)":[4],"gene":[5,27,184],"is":[6,15,28,37,54,75],"activated":[7],"in":[8,164],"the":[9,24,58,71,79,106,120,134,150,180,187,190,194,201],"earliest":[10],"cell":[12,19,86,212],"precursors":[13],"and":[14,65,102,117,193,200],"expressed":[16],"throughout":[17],"development.":[20],"Tissue-specific":[21],"expression":[22,185],"of":[23,42,57,115,137,149,179,182,189],"murine":[25],"controlled":[29],"by":[30,39],"a":[31,40,49,97,173],"promoter":[34,192],"whose":[35],"activity":[36,136],"governed":[38],"cassette":[41],"upstream":[43,195],"transcriptional":[44],"silencers.":[45],"This":[46,153],"study":[47],"describes":[48],"potent":[50],"new":[51,72],"silencer":[52,62,74,196],"that":[53,142,167],"located":[55],"5'":[56],"previously":[59],"identified":[60],"elements,":[63,70],"FROG":[64],"TOAD.":[66],"Like":[67],"these":[68],"known":[69],"not":[76],"restricted":[77],"to":[78,105],"promoter.":[81,152],"Nuclear":[82],"proteins":[83,163],"from":[84],"all":[85],"lines":[87],"tested":[88],"interacted":[89,158],"with":[90,119,159],"this":[91,138],"A+T-rich":[92,122,155,202],"sequence,":[93],"which":[94],"closely":[95],"resembled":[96],"noncanonical":[98],"octamer":[99],"binding":[100,130,145,204],"motif":[101,205],"also":[103,146,170],"conformed":[104],"consensus":[107],"sequence":[108,123,139,156],"for":[109,133,209],"nuclear":[110,161],"matrix":[111,162,174],"attachment":[112,175],"regions.":[113],"Interaction":[114],"Oct-1":[116],"Oct-2":[118],"was":[124,131],"confirmed":[125],"using":[126],"octamer-specific":[127],"Abs.":[128],"Oct-1/Oct-2":[129,144,203],"required":[132],"inhibitory":[135],"because":[140],"mutations":[141],"blocked":[143],"eliminated":[147],"inhibition":[148],"specifically":[157],"isolated":[160],"vitro,":[165],"suggesting":[166],"it":[168],"may":[169,206],"function":[171],"as":[172],"region":[176],"element.":[177],"Maintenance":[178],"level":[181],"through":[186],"interaction":[188],"minimal":[191],"elements":[197],"FROG,":[198],"TOAD,":[199],"be":[207],"essential":[208],"normal":[210],"development":[213],"and/or":[214],"function.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}