{"id":"https://openalex.org/W167933254","doi":null,"title":"Resistencias bacterianas y un nuevo antibi\u00f3tico: la tigeciclina","display_name":"Resistencias bacterianas y un nuevo antibi\u00f3tico: la tigeciclina","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W167933254","mag":"167933254"},"language":"es","primary_location":{"id":"pmh:oai:hispana.mcu.es:285374","doi":null,"is_oa":false,"landing_page_url":"https://hispana.mcu.es/es/registros/registro.do?tipoRegistro=MTD&idBib=285374","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Espa\u00f1ola de Quimioterapia, ISSN 0214-3429, Vol. 19, N\u00ba. 3, 2006, pags. 209-219","raw_type":"text (article)"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105358975","display_name":"M Gobernado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M Gobernado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5105358975"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4233,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62289466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"3","first_page":"209","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tigecycline","display_name":"tigecycline","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7409999966621399},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.675000011920929},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/methicillin-resistance","display_name":"methicillin resistance","score":0.7059999704360962},{"id":"https://openalex.org/keywords/meca","display_name":"mecA gene","score":0.5490000247955322},{"id":"https://openalex.org/keywords/mecc-gene","display_name":"mecC gene","score":0.5260000228881836},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"horizontal gene transfer","score":0.6209999918937683},{"id":"https://openalex.org/keywords/conjugation","display_name":"conjugation","score":0.5120000243186951},{"id":"https://openalex.org/keywords/transduction","display_name":"transduction","score":0.6629999876022339},{"id":"https://openalex.org/keywords/transformation","display_name":"transformation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.6850000023841858},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7072678804397583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32941511273384094},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.17451053857803345}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:hispana.mcu.es:285374","doi":null,"is_oa":false,"landing_page_url":"https://hispana.mcu.es/es/registros/registro.do?tipoRegistro=MTD&idBib=285374","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Espa\u00f1ola de Quimioterapia, ISSN 0214-3429, Vol. 19, N\u00ba. 3, 2006, pags. 209-219","raw_type":"text (article)"},{"id":"mag:167933254","doi":null,"is_oa":false,"landing_page_url":"http://seq.es/seq/0214-3429/19/3/M_Gobernado_Editorial.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S976986303","display_name":"Revista espa\u00f1ola de quimioterapia. Suplemento","issn_l":"1130-331X","issn":["1130-331X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista espa\u00f1ola de quimioterapia. Suplemento","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W16055280","https://openalex.org/W58535851","https://openalex.org/W123874284","https://openalex.org/W162410508","https://openalex.org/W1502809559","https://openalex.org/W1521047189","https://openalex.org/W1522563507","https://openalex.org/W1650702909","https://openalex.org/W1965078590","https://openalex.org/W1966607535","https://openalex.org/W1967865545","https://openalex.org/W1970548642","https://openalex.org/W1973393074","https://openalex.org/W1974100638","https://openalex.org/W1976898407","https://openalex.org/W1977502109","https://openalex.org/W1983269321","https://openalex.org/W1988750503","https://openalex.org/W1990434517","https://openalex.org/W1993320463","https://openalex.org/W1993543372","https://openalex.org/W1993886815","https://openalex.org/W1995489787","https://openalex.org/W2001555823","https://openalex.org/W2003350949","https://openalex.org/W2008054915","https://openalex.org/W2009889907","https://openalex.org/W2012007578","https://openalex.org/W2016617353","https://openalex.org/W2017045389","https://openalex.org/W2018883772","https://openalex.org/W2019417380","https://openalex.org/W2021647250","https://openalex.org/W2026734017","https://openalex.org/W2028095842","https://openalex.org/W2031303083","https://openalex.org/W2034482054","https://openalex.org/W2037488471","https://openalex.org/W2037630809","https://openalex.org/W2038866349","https://openalex.org/W2048323938","https://openalex.org/W2049692280","https://openalex.org/W2050379189","https://openalex.org/W2052075229","https://openalex.org/W2054740361","https://openalex.org/W2065453013","https://openalex.org/W2065928426","https://openalex.org/W2067724722","https://openalex.org/W2069416660","https://openalex.org/W2072175080","https://openalex.org/W2072219261","https://openalex.org/W2080598875","https://openalex.org/W2083296033","https://openalex.org/W2087901245","https://openalex.org/W2088048768","https://openalex.org/W2089068120","https://openalex.org/W2089493916","https://openalex.org/W2094217997","https://openalex.org/W2098300624","https://openalex.org/W2101570801","https://openalex.org/W2101696246","https://openalex.org/W2102200481","https://openalex.org/W2102439233","https://openalex.org/W2106373938","https://openalex.org/W2109071042","https://openalex.org/W2112578254","https://openalex.org/W2115255353","https://openalex.org/W2116492265","https://openalex.org/W2119142507","https://openalex.org/W2119703826","https://openalex.org/W2120654979","https://openalex.org/W2120706333","https://openalex.org/W2121175754","https://openalex.org/W2123689798","https://openalex.org/W2124763838","https://openalex.org/W2125283507","https://openalex.org/W2125474917","https://openalex.org/W2126035312","https://openalex.org/W2128427874","https://openalex.org/W2131525143","https://openalex.org/W2131946678","https://openalex.org/W2134607027","https://openalex.org/W2134937983","https://openalex.org/W2135161828","https://openalex.org/W2135783500","https://openalex.org/W2136167568","https://openalex.org/W2139704622","https://openalex.org/W2139818499","https://openalex.org/W2140204914","https://openalex.org/W2142004410","https://openalex.org/W2143941770","https://openalex.org/W2144908107","https://openalex.org/W2146349335","https://openalex.org/W2146844783","https://openalex.org/W2153590024","https://openalex.org/W2153868993","https://openalex.org/W2156737450","https://openalex.org/W2157622488","https://openalex.org/W2161339027","https://openalex.org/W2162067003","https://openalex.org/W2163961087","https://openalex.org/W2166215201","https://openalex.org/W2167119990","https://openalex.org/W2167182275","https://openalex.org/W2167385770","https://openalex.org/W2168550647","https://openalex.org/W2169504919","https://openalex.org/W2170664206","https://openalex.org/W2170885587","https://openalex.org/W2171155970","https://openalex.org/W2172156934","https://openalex.org/W2400601374","https://openalex.org/W2463108599","https://openalex.org/W4255959192"],"related_works":["https://openalex.org/W7033626338","https://openalex.org/W4410360749","https://openalex.org/W1576097553","https://openalex.org/W3212236397","https://openalex.org/W7216696643","https://openalex.org/W2000537484","https://openalex.org/W2911138705","https://openalex.org/W6969142035","https://openalex.org/W2949922349","https://openalex.org/W7216555648"],"abstract_inverted_index":{"medades":[0],"infecciosas":[1],"y":[2,123,138,178,192,201,220,258,283,321,351,404],"la":[3,62,75,95,111,143,152,170,209,235,269,314,348,362,391],"dificultad,":[4],"cada":[5],"vez":[6],"mas":[7,155,224,286],"frecuente,":[8],"de":[9,39,45,61,64,73,81,116,118,127,129,145,147,156,175,183,206,208,243,253,294,300,324,332,340,347,364,396,399,430],"su":[10,132,244],"tratamiento.":[11],"Esta":[12,67],"dificultad":[13],"se":[14,78,97,108,212,231,246,251,352],"encuentra,":[15],"sobre":[16],"todo,":[17],"en":[18,34,58,104,135,169,173,233,265,276,304,370,372],"las":[19,65,130,341,410],"infecciones":[20,342],"causadas":[21],"por":[22,99,120,256],"bacterias":[23],"que":[24,46,107,250,387,390],"han":[25],"adquirido":[26],"resistencia":[27,63,89,119,164,230,270,327],"a":[28,71,110,216,285,307,313,322,354,361,368,378,402],"los":[29,139,301,388],"antibioticos,":[30],"cuyo":[31],"numero":[32],"va":[33],"aumento.":[35],"Para":[36,227,291],"combatir":[37,228],"algunas":[38],"estas":[40,295,333],"enfermedades":[41],"nos":[42],"damos":[43],"cuenta":[44],"el":[47,59,105,266,292,298,373],"armamentarium":[48],"terapeutico":[49],"es":[50],"muy":[51],"reducido.":[52],"Desde":[53],"hace":[54],"anos":[55],"estamos":[56],"inmersos":[57],"problema":[60,383],"bacterias.":[66],"comenzo":[68],"pronto,":[69],"pues":[70],"poco":[72,205,241],"introducirse":[74],"penicilina":[76,210,363],"ya":[77,211,279,335,386],"detectaron":[79,213,247],"cepas":[80,214,248,296,309,334,412],"Staphylococcus":[82],"aureus":[83],"resistentes":[84,215],"al":[85,240,280],"nuevo":[86],"antimicrobiano.":[87],"La":[88,125],"puede":[90],"ser":[91,379],"natural":[92],"o":[93,317],"adquirida;":[94],"adquirida":[96],"produce":[98],"evolucion":[100],"vertical":[101],"(mutaciones":[102],"espontaneas":[103],"cromosoma":[106],"transmiten":[109],"descendencia)":[112],"u":[113],"horizontal":[114,398],"(transmision":[115],"genes":[117,389],"conjugacion,":[121],"transduccion":[122],"transformacion).":[124],"rapidez":[126],"desarrollo":[128],"bacterias,":[131],"concentracion":[133],"alta":[134],"muchos":[136],"ambientes":[137],"procesos":[140],"geneticos":[141],"determinan":[142],"posibilidad":[144],"adicion":[146],"resistencias":[148,360],"con":[149,310,326,413],"facilidad.":[150],"En":[151,263,408],"actualidad":[153],"hay":[154],"veinte":[157],"especies":[158],"bacterianas":[159],"habituales":[160],"entre":[161,405],"nosotros":[162],"cuya":[163],"tiene":[165],"un":[166,382],"efecto":[167],"negativo":[168],"salud":[171],"humana,":[172],"terminos":[174],"morbilidad,":[176],"mortalidad":[177,356],"repercusion":[179],"economica":[180],"(1-4).":[181],"Son":[182],"especial":[184],"preocupacion":[185],"S.":[186,365],"aureus,":[187],"Streptococcus":[188],"pneumoniae,":[189,198],"Enterococcus":[190,193],"faecalis":[191],"faecium,":[194],"Escherichia":[195],"coli,":[196],"Klebsiella":[197],"Pseudomonas":[199],"aeruginosa":[200],"Acinetobacter":[202],"baumanii.":[203],"A":[204],"disponer":[207],"esta":[217,229],"(5,":[218],"6),":[219],"ahora":[221],"lo":[222,345],"son":[223,337,346,393],"del":[225,273,287],"90%.":[226],"introdujo":[232],"1956":[234],"meticilina":[236],"(7),":[237],"pero":[238,303],"tambien":[239,344],"tiempo":[242],"lanzamiento":[245],"resistentes,":[249],"extendieron":[252],"forma":[254],"rapida":[255],"Europa":[257],"Estados":[259],"Unidos":[260],"(6,":[261],"8).":[262],"Espana,":[264,409],"ano":[267,374],"1987":[268],"era":[271],"menor":[272],"2%":[274],"(9),":[275],"1996":[277,305],"llegaba":[278],"18%":[281],"(10)":[282],"posteriormente":[284],"25%":[288],"(11,":[289],"12).":[290],"tratamiento":[293],"quedo":[297],"recurso":[299],"glucopeptidos,":[302],"comenzaron":[306],"aparecer":[308],"sensibilidad":[311],"intermedia":[312],"vancomicina":[315],"(VISA":[316],"GISA)":[318],"(13,":[319],"14)":[320],"partir":[323],"2002":[325],"total":[328],"(VRSA)":[329],"(15).":[330],"Algunas":[331],"no":[336],"patrimonio":[338],"exclusivo":[339],"hospitalarias;":[343],"comunidad":[349],"(16-20)":[350],"asocian":[353],"mayor":[355],"(1).":[357],"Las":[358],"primeras":[359,411],"pneumoniae":[366],"empezaron":[367],"detectarse":[369],"Sudafrica":[371],"1967":[375],"(21-24),":[376],"pasando":[377],"desde":[380],"entonces":[381],"mundial":[384],"(25),":[385],"codifican":[392],"facilmente":[394],"difundibles":[395],"manera":[397],"unos":[400],"paises":[401],"otros":[403],"continentes":[406],"(26).":[407],"disRev":[414],"Esp":[415],"Quimioterap,":[416],"Septiembre":[417],"2006;":[418],"Vol.":[419],"19":[420],"(No":[421],"3):":[422],"209-219":[423],"\u00a9":[424],"2006":[425],"Prous":[426],"Science,":[427],"S.A.Sociedad":[428],"Espanola":[429],"Quimioterapia":[431]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}