{"id":"https://openalex.org/W167929339","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.659.13","title":"Attenuation of methamphetamine\u2010induced neurotoxicity by selective sigma receptor ligands: in vivo and in vitro studies","display_name":"Attenuation of methamphetamine\u2010induced neurotoxicity by selective sigma receptor ligands: in vivo and in vitro studies","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W167929339","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.659.13","mag":"167929339"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.659.13","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.659.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.659.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087856092","display_name":"Rae R. Matsumoto","orcid":"https://orcid.org/0000-0002-0558-1268","observed_orcids":["https://orcid.org/0000-0002-0558-1268"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rae Matsumoto","raw_affiliation_strings":["West Virginia University Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079780675","display_name":"Nidhi Kaushal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nidhi Kaushal","raw_affiliation_strings":["West Virginia University Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082550457","display_name":"Matthew James Robson","orcid":"https://orcid.org/0000-0002-3277-3062","observed_orcids":["https://orcid.org/0000-0002-3277-3062"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Robson","raw_affiliation_strings":["West Virginia University Morgantown WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University Morgantown WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044827754","display_name":"Christopher R. McCurdy","orcid":"https://orcid.org/0000-0001-8695-2915","observed_orcids":["https://orcid.org/0000-0001-8695-2915"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher McCurdy","raw_affiliation_strings":["University of Mississippi University MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mississippi University MS","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078066729","display_name":"Andrew Coop","orcid":"https://orcid.org/0000-0002-4913-9447","observed_orcids":["https://orcid.org/0000-0002-4913-9447"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Coop","raw_affiliation_strings":["University of Maryland Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Baltimore MD","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1492,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53442993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.972000002861023},{"id":"https://openalex.org/keywords/sigma-receptors","display_name":"sigma receptors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/sigma-receptor-ligands","display_name":"sigma receptor ligands","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9769999980926514},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9559999704360962},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9610000252723694},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.9869999885559082},{"id":"https://openalex.org/keywords/caspase-pathway","display_name":"caspase pathway","score":0.9179999828338623},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ng108-15-cells","display_name":"NG108-15 cells","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C103133801","wikidata":"https://www.wikidata.org/wiki/Q408572","display_name":"Sigma-1 receptor","level":4,"score":0.9331337213516235},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8588994741439819},{"id":"https://openalex.org/C2780114369","wikidata":"https://www.wikidata.org/wiki/Q6823535","display_name":"Meth-","level":5,"score":0.8165125846862793},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.7792088985443115},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6469883918762207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6334744691848755},{"id":"https://openalex.org/C2777052854","wikidata":"https://www.wikidata.org/wiki/Q7512419","display_name":"Sigma receptor","level":3,"score":0.6181561946868896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.541074275970459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5017518997192383},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.49581703543663025},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46620428562164307},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.41746118664741516},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3116271197795868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3106343746185303},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1726282238960266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1690414547920227},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.1255786418914795},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.07885554432868958},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2779989194","wikidata":"https://www.wikidata.org/wiki/Q343016","display_name":"Acrylate","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.659.13","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.659.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.659.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3209391514","https://openalex.org/W2276288467","https://openalex.org/W2149616186","https://openalex.org/W2093339161","https://openalex.org/W1964780666","https://openalex.org/W2030714536","https://openalex.org/W1979175249","https://openalex.org/W1969060538","https://openalex.org/W2766333720","https://openalex.org/W225903741"],"abstract_inverted_index":{"Methamphetamine":[0],"(METH)":[1],"is":[2,13],"one":[3],"of":[4,15,56,63,76,91,98,126,128,147],"the":[5,60,88,92,129,134,145,148,152],"most":[6],"widely":[7],"abused":[8],"illicit":[9],"substances":[10],"worldwide.":[11],"It":[12],"capable":[14],"causing":[16],"hyperthermia":[17,49],"and":[18,36,65,71,101],"neurotoxicity":[19,58],"after":[20],"high":[21],"and/or":[22],"repeated":[23],"dosing.":[24],"Selective":[25],"ligands":[26,94,119,158],"for":[27],"sigma":[28,93,118,130,156],"receptors":[29],"were":[30],"developed":[31],"by":[32,115],"our":[33],"research":[34],"team":[35],"shown":[37],"in":[38,41,59,69,120,133],"preclinical":[39],"studies":[40],"male,":[42],"Swiss":[43],"Webster":[44],"mice":[45],"to":[46,83,166],"significantly":[47],"attenuate":[48],"as":[50,52],"well":[51],"several":[53],"classical":[54],"markers":[55],"METH":[57,167],"striatum:":[61],"depletion":[62],"dopamine":[64,70],"5\u2010HT":[66,72],"levels,":[67],"reductions":[68],"transporter":[73],"expression.":[74],"Use":[75],"an":[77],"NG108\u201315":[78,121],"cell":[79],"culture":[80],"model":[81],"system":[82],"further":[84],"delineate":[85],"mechanisms":[86,163],"underlying":[87],"protective":[89],"effects":[90,136],"reveals":[95],"significant":[96],"attenuation":[97],"METH\u2010induced":[99,107],"ROS/RNS":[100],"caspase":[102],"dependent":[103],"pathways.":[104],"In":[105],"contrast,":[106],"endoplasmic":[108],"reticulum":[109],"stress":[110],"pathways":[111],"are":[112,137],"less":[113],"affected":[114],"intervention":[116],"with":[117,141],"cells.":[122],"The":[123],"relative":[124],"contribution":[125],"each":[127],"receptor":[131,157],"subtypes":[132],"neuroprotective":[135],"still":[138],"being":[139],"elucidated,":[140],"preliminary":[142],"data":[143,153],"suggesting":[144],"importance":[146],"sigma\u20102":[149],"subtype.":[150],"Together,":[151],"indicate":[154],"that":[155,164],"can":[159],"intervene":[160],"at":[161],"numerous":[162],"contribute":[165],"neurotoxicity.":[168],"[Funding":[169],"from":[170],"NIDA:":[171],"DA013978":[172],",":[173],"DA023205":[174],"]":[175]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}
