{"id":"https://openalex.org/W167923990","doi":null,"title":"[Effects of sodium selenite on telomerase activity and telomere length].","display_name":"[Effects of sodium selenite on telomerase activity and telomere length].","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W167923990","mag":"167923990","pmid":"https://pubmed.ncbi.nlm.nih.gov/14673504"},"language":"zh","primary_location":{"id":"pmid:14673504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14673504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100336311","display_name":"Qiong Liu","orcid":"https://orcid.org/0000-0002-6431-3650","observed_orcids":["https://orcid.org/0000-0002-6431-3650"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Liu","raw_affiliation_strings":["Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China. qiongliu_hust@163.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China. qiongliu_hust@163.net","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023387676","display_name":"Decong Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De-Cong Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044107778","display_name":"Chaojian Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao-Jian Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065593723","display_name":"Heng Xiao","orcid":"https://orcid.org/0000-0002-6437-0938","observed_orcids":["https://orcid.org/0000-0002-6437-0938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heng Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100525787","display_name":"Hui-Bi Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Bi Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017730870","display_name":"Baihua Shu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bai-Hua Shu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102230658","display_name":"Shun-Qing Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shun-Qing Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1823,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.54320642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"12","first_page":"1117","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-selenite","display_name":"sodium selenite","score":0.9990000128746033},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.8610000014305115},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":1.0},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7329999804496765},{"id":"https://openalex.org/keywords/l02-cells","display_name":"L02 cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cell-lifespan","display_name":"cell lifespan","score":0.5120000243186951},{"id":"https://openalex.org/keywords/anti-senescence","display_name":"anti-senescence","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9592790007591248},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9377433061599731},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.7788238525390625},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.6747590899467468},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6108851432800293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4926522374153137},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4560915529727936},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42574840784072876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39545994997024536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3383723497390747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32748955488204956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2527848184108734},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018038","descriptor_name":"Sodium Selenite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14673504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14673504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica","raw_type":"English Abstract"},{"id":"mag:167923990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14673504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133726744","https://openalex.org/W134065605","https://openalex.org/W2563524108","https://openalex.org/W2353144186","https://openalex.org/W2890657103","https://openalex.org/W2891094828","https://openalex.org/W2259394863","https://openalex.org/W2522797895","https://openalex.org/W2373465561","https://openalex.org/W2368600894"],"abstract_inverted_index":{"To":[0],"study":[1],"the":[2,21,23,110,120,165,186],"biological":[3],"basis":[4],"of":[5,26,41,80,146,168,189],"selenium":[6],"in":[7,90,109,119],"resisting":[8],"senescence":[9],"through":[10,85,171],"its":[11],"effects":[12],"on":[13],"cellular":[14,135],"telomerase":[15,49,72,100,136,173],"activity":[16,50,101,137,174],"and":[17,44,58,88,102,138,175],"telomere":[18,81,144,176],"length.":[19,177],"In":[20],"experiments,":[22],"cell":[24],"line":[25],"hepatocytes":[27,169],"L-02":[28,96,147,170],"was":[29,51,66,83,149],"divided":[30],"into":[31],"three":[32],"groups":[33],"supplemented":[34,122],"with":[35,123,154],"sodium":[36,128,131,155,158],"selenite":[37,132,159],"at":[38,160],"final":[39],"concentrations":[40],"0,":[42],"0.5":[43,124],"2.5":[45,126],"micromol/L,":[46],"respectively.":[47],"Cellular":[48],"measured":[52],"by":[53],"telomeric":[54],"repeat":[55],"amplification":[56],"protocol":[57],"enzymatic":[59],"luminometric":[60],"inorganic":[61],"pyrophosphate":[62],"detection":[63],"assay.":[64],"RT-PCR":[65],"used":[67],"to":[68],"semi-quantitatively":[69],"detect":[70],"human":[71],"reverse":[73],"transcriptase":[74],"(hTERT)":[75],"gene":[76,104,140],"expression.":[77],"The":[78,113,143],"change":[79],"length":[82,145],"assayed":[84],"flow":[86],"cytometry":[87],"fluorescence":[89],"situ":[91],"hybridization.":[92],"Results":[93],"showed":[94],"that":[95],"cells":[97,114,148],"had":[98],"low":[99],"hTERT":[103,139],"expression":[105,141],"level":[106],"when":[107],"cultured":[108],"normal":[111],"way.":[112],"grew":[115],"well":[116],"after":[117,152],"3-week-cultivation":[118],"media":[121],"or":[125],"micromol/L":[127],"selenite.":[129,156],"Besides,":[130],"significantly":[133],"increased":[134],"level.":[142],"also":[150],"extended":[151],"4-week-cultivation":[153],"Thus,":[157],"nutritional":[161],"doses":[162],"could":[163],"prolong":[164],"life":[166],"span":[167],"increasing":[172],"This":[178],"result":[179],"provides":[180],"a":[181],"possible":[182],"mechanism":[183],"for":[184],"explaining":[185],"anti-senescence":[187],"function":[188],"selenium.":[190]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}