{"id":"https://openalex.org/W1678283822","doi":"https://doi.org/10.1507/endocrj.ej11-0064","title":"Glucose-incretin interaction revisited [Review]","display_name":"Glucose-incretin interaction revisited [Review]","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1678283822","doi":"https://doi.org/10.1507/endocrj.ej11-0064","mag":"1678283822","pmid":"https://pubmed.ncbi.nlm.nih.gov/21701075"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.ej11-0064","doi":"https://doi.org/10.1507/endocrj.ej11-0064","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej11-0064","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj/58/7/58_EJ11-0064/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj/58/7/58_EJ11-0064/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101598632","display_name":"Hiroaki Ishii","orcid":"https://orcid.org/0000-0003-4182-0876","observed_orcids":["https://orcid.org/0000-0003-4182-0876"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Ishii","raw_affiliation_strings":["Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001023403","display_name":"Yoshihiko Sato","orcid":"https://orcid.org/0009-0007-1614-9028","observed_orcids":["https://orcid.org/0009-0007-1614-9028","https://orcid.org/0000-0002-2416-534X"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Sato","raw_affiliation_strings":["Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088923383","display_name":"Masahiro Takei","orcid":"https://orcid.org/0000-0001-6562-6520","observed_orcids":["https://orcid.org/0000-0001-6562-6520"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Takei","raw_affiliation_strings":["Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024982638","display_name":"Shin\u2010ichi Nishio","orcid":"https://orcid.org/0000-0003-2792-0862","observed_orcids":["https://orcid.org/0000-0003-2792-0862"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Nishio","raw_affiliation_strings":["Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041859138","display_name":"Mitsuhisa Komatsu","orcid":"https://orcid.org/0000-0002-1359-9732","observed_orcids":["https://orcid.org/0000-0002-1359-9732"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhisa Komatsu","raw_affiliation_strings":["Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto 390-8621, Japan","institution_ids":["https://openalex.org/I137975476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I137975476"],"apc_list":null,"apc_paid":null,"fwci":0.1817,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.16257089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"58","issue":"7","first_page":"519","last_page":"525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.574999988079071},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.968999981880188},{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.8539999723434448},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.765999972820282},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulinotropic-effect","display_name":"insulinotropic effect","score":0.5009999871253967},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.8083579540252686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6696171760559082},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6677244901657104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6422363519668579},{"id":"https://openalex.org/C102942909","wikidata":"https://www.wikidata.org/wiki/Q7636212","display_name":"Sulfonylurea receptor","level":4,"score":0.6350944638252258},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.47136107087135315},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.4533391296863556},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.44542399048805237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4445308744907379},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.35414183139801025},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.31917673349380493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3112224042415619},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.2774391174316406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24959459900856018},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.07113009691238403}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054086","descriptor_name":"KATP Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1507/endocrj.ej11-0064","doi":"https://doi.org/10.1507/endocrj.ej11-0064","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej11-0064","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj/58/7/58_EJ11-0064/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:21701075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21701075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00990:0001368137","doi":null,"is_oa":true,"landing_page_url":"https://soar-ir.repo.nii.ac.jp/records/3748","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ENDOCRINE JOURNAL","raw_type":"journal article"},{"id":"pmh:oai:soar-ir.repo.nii.ac.jp:00003748","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10091/17576","pdf_url":null,"source":{"id":"https://openalex.org/S4306402150","display_name":"SOAR (Shinshu University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137975476","host_organization_name":"Shinshu University","host_organization_lineage":["https://openalex.org/I137975476"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1507/endocrj.ej11-0064","doi":"https://doi.org/10.1507/endocrj.ej11-0064","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej11-0064","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj/58/7/58_EJ11-0064/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1113855041","display_name":"Identification of novel acylated proteins regulating insulin secretion and exploration of their physiological significance","funder_award_id":"21591128","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8683390480","display_name":"The effect of estrogen for carbohydrate metabolism in pancreatic beta cells","funder_award_id":"22591853","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1678283822.pdf","grobid_xml":"https://content.openalex.org/works/W1678283822.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1499384204","https://openalex.org/W1969501284","https://openalex.org/W1971639785","https://openalex.org/W1971882473","https://openalex.org/W1978164544","https://openalex.org/W1981153465","https://openalex.org/W1982365101","https://openalex.org/W1984297603","https://openalex.org/W1993038809","https://openalex.org/W1995155295","https://openalex.org/W2013253832","https://openalex.org/W2022430914","https://openalex.org/W2022712307","https://openalex.org/W2028735594","https://openalex.org/W2032322539","https://openalex.org/W2044397645","https://openalex.org/W2046208788","https://openalex.org/W2053924869","https://openalex.org/W2054406740","https://openalex.org/W2070439478","https://openalex.org/W2077149049","https://openalex.org/W2078312203","https://openalex.org/W2078668720","https://openalex.org/W2081102637","https://openalex.org/W2085760982","https://openalex.org/W2095712584","https://openalex.org/W2097386087","https://openalex.org/W2100271953","https://openalex.org/W2104089887","https://openalex.org/W2105100736","https://openalex.org/W2109728760","https://openalex.org/W2122568821","https://openalex.org/W2123308029","https://openalex.org/W2124971376","https://openalex.org/W2131441008","https://openalex.org/W2139880338","https://openalex.org/W2142797092","https://openalex.org/W2164861152","https://openalex.org/W2171294019","https://openalex.org/W2171483278","https://openalex.org/W2330273698"],"related_works":["https://openalex.org/W2139880338","https://openalex.org/W2053527696","https://openalex.org/W1990501602","https://openalex.org/W1993038809","https://openalex.org/W2018367140","https://openalex.org/W7097664432","https://openalex.org/W1981153465","https://openalex.org/W2017184556","https://openalex.org/W2035748369","https://openalex.org/W2981356167"],"abstract_inverted_index":{"Pancreatic":[0],"beta":[1,33,136],"cell":[2],"dysfunction":[3],"is":[4,16,92,98,119,172,205,231],"pivotal":[5],"to":[6,46,121,178],"the":[7,26,37,49,94,123,126,134,208,217,220],"development":[8],"of":[9,13,17,25,28,40,52,68,76,84,112,129,169,188,194,211,219,229],"diabetes,":[10],"and":[11,35,74,97,152,214,225],"restoration":[12],"insulin":[14,29,56,61,89,109,146,162,180],"action":[15,114,187],"primary":[18],"importance.":[19],"Here,":[20],"we":[21],"present":[22],"a":[23],"review":[24],"mechanism":[27],"secretion":[30,57,62],"by":[31,66,100,148],"pancreatic":[32,135],"cells":[34],"discuss":[36],"mutual":[38],"interaction":[39],"signaling":[41,224],"pathways":[42],"in":[43,198],"stimulus-secretion":[44],"coupling":[45],"better":[47],"understand":[48],"scientific":[50],"basis":[51,128],"pharmacological":[53],"treatment":[54],"for":[55,176],"deficiency.":[58],"Glucose":[59,106],"stimulates":[60,108],"via":[63],"membrane":[64],"depolarization":[65],"closure":[67],"ATP-sensitive":[69],"K(+)":[70],"channels":[71],"(K(ATP)":[72],"channels)":[73],"opening":[75],"L-type":[77],"voltage-dependent":[78],"Ca(2+)":[79,87],"channels.":[80,105,117],"The":[81,166,190],"resultant":[82],"elevation":[83],"cytosolic":[85],"free":[86],"triggers":[88],"exocytosis.":[90],"This":[91,118],"termed":[93],"\"K(ATP)-dependent":[95],"pathway\"":[96],"shared":[99],"sulfonylurea,":[101],"which":[102,130,143],"closes":[103],"K(ATP)":[104,116,226],"also":[107],"release":[110,147,163],"independent":[111],"its":[113],"on":[115],"referred":[120],"as":[122],"\"K(ATP)-independent":[124],"pathway,\"":[125],"molecular":[127],"remains":[131],"elusive.":[132],"In":[133],"cell,":[137],"incretin":[138,177],"hormones":[139],"increase":[140],"cAMP":[141,156,223],"level,":[142],"enhances":[144,184],"glucose-stimulated":[145],"protein":[149],"kinase":[150],"A-dependent":[151],"-independent":[153],"mechanisms.":[154],"Importantly,":[155],"does":[157],"not":[158],"directly":[159],"augment":[160],"Ca(2+)-stimulated":[161],"per":[164],"se.":[165],"stimulatory":[167],"level":[168],"ambient":[170],"glucose":[171,230],"an":[173],"absolute":[174],"requirement":[175],"enhance":[179],"release.":[181],"Therefore,":[182],"incretin/cAMP":[183],"K(ATP)-independent":[185],"insulinotropic":[186],"glucose.":[189],"robust":[191],"glucose-lowering":[192],"effect":[193],"DPP4":[195,212],"inhibitor":[196,213],"add-on":[197],"diabetic":[199],"patients":[200],"with":[201],"sulfonylurea":[202],"secondary":[203],"failure":[204],"intriguing.":[206],"With":[207],"clinical":[209],"availability":[210],"GLP-1":[215],"mimetics,":[216],"importance":[218],"interactions":[221],"between":[222],"channel-independent":[227],"actions":[228],"reappraised.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
