{"id":"https://openalex.org/W1677709368","doi":"https://doi.org/10.7490/f1000research.23.1","title":"Cdk5 limits Src activity by targeting c-Src ubiquitin-dependent degradation","display_name":"Cdk5 limits Src activity by targeting c-Src ubiquitin-dependent degradation","publication_year":2010,"publication_date":"2010-03-31","ids":{"openalex":"https://openalex.org/W1677709368","doi":"https://doi.org/10.7490/f1000research.23.1","mag":"1677709368"},"language":"en","primary_location":{"id":"mag:1677709368","doi":"https://doi.org/10.7490/f1000research.23.1","is_oa":false,"landing_page_url":"https://f1000research.com/posters/23","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"F1000Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100611791","display_name":"Feng Qiao","orcid":"https://orcid.org/0000-0002-1704-7257","observed_orcids":["https://orcid.org/0000-0002-1704-7257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Qiao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1704-7257","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018938895","display_name":"Quan Pan","orcid":"https://orcid.org/0000-0001-8327-9657","observed_orcids":["https://orcid.org/0000-0001-8327-9657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quan Pan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8327-9657","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103366369","display_name":"C.Y. Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.Y. Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108453115","display_name":"Peggy S. Zelenka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy S. Zelenka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06865057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9810000061988831},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.878000020980835},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.824999988079071},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.7548703551292419},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6713880896568298},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6665686368942261},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5936426520347595},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.5867177844047546},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4310368299484253},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.4277898073196411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35588836669921875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32322174310684204},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.25876951217651367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19820430874824524},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.12264877557754517},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11000895500183105},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.049999386072158813},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.045671164989471436},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.0},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1677709368","doi":"https://doi.org/10.7490/f1000research.23.1","is_oa":false,"landing_page_url":"https://f1000research.com/posters/23","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"F1000Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034935389","https://openalex.org/W7097664121","https://openalex.org/W1186361427","https://openalex.org/W2269257088","https://openalex.org/W2108524755","https://openalex.org/W946018628","https://openalex.org/W2018434227","https://openalex.org/W4365790554","https://openalex.org/W2742038014","https://openalex.org/W1028788800"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}