{"id":"https://openalex.org/W1677542072","doi":"https://doi.org/10.4049/jimmunol.192.supp.64.2","title":"RGC-32 is essential for TGF-\u03b2 mediated Th17 cell differentiation (LYM3P.728)","display_name":"RGC-32 is essential for TGF-\u03b2 mediated Th17 cell differentiation (LYM3P.728)","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1677542072","doi":"https://doi.org/10.4049/jimmunol.192.supp.64.2","mag":"1677542072"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.192.supp.64.2","doi":"https://doi.org/10.4049/jimmunol.192.supp.64.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.64.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111541015","display_name":"Violeta Rus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210140381","display_name":"Baltimore VA Medical Center","ror":"https://ror.org/036a0e562","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210140381","https://openalex.org/I4210163125"]},{"id":"https://openalex.org/I4210163125","display_name":"VA Maryland Health Care System","ror":"https://ror.org/05ax3zh38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210163125"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Violeta Rus","raw_affiliation_strings":["Medicine, University of Maryland at Baltimore , Baltimore, MD","Research Service, VAMHCS , Baltimore, MD","1Medicine, University of Maryland at Baltimore, Baltimore, MD","3Research Service, VAMHCS, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Maryland at Baltimore , Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Research Service, VAMHCS , Baltimore, MD","institution_ids":["https://openalex.org/I4210163125"]},{"raw_affiliation_string":"1Medicine, University of Maryland at Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"3Research Service, VAMHCS, Baltimore, MD","institution_ids":["https://openalex.org/I4210140381","https://openalex.org/I4210163125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028505493","display_name":"Cosmin Tegla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210140381","display_name":"Baltimore VA Medical Center","ror":"https://ror.org/036a0e562","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210140381","https://openalex.org/I4210163125"]},{"id":"https://openalex.org/I4210163125","display_name":"VA Maryland Health Care System","ror":"https://ror.org/05ax3zh38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210163125"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cosmin Tegla","raw_affiliation_strings":["Neurology, University of Maryland at Baltimore , Baltimore, MD","Research Service, VAMHCS , Baltimore, MD","2Neurology, University of Maryland at Baltimore, Baltimore, MD","3Research Service, VAMHCS, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, University of Maryland at Baltimore , Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Research Service, VAMHCS , Baltimore, MD","institution_ids":["https://openalex.org/I4210163125"]},{"raw_affiliation_string":"2Neurology, University of Maryland at Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"3Research Service, VAMHCS, Baltimore, MD","institution_ids":["https://openalex.org/I4210140381","https://openalex.org/I4210163125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070794279","display_name":"Vinh Q Nguyen","orcid":"https://orcid.org/0000-0001-9564-9037","observed_orcids":["https://orcid.org/0000-0001-9564-9037"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210140381","display_name":"Baltimore VA Medical Center","ror":"https://ror.org/036a0e562","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210140381","https://openalex.org/I4210163125"]},{"id":"https://openalex.org/I4210163125","display_name":"VA Maryland Health Care System","ror":"https://ror.org/05ax3zh38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210163125"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinh Nguyen","raw_affiliation_strings":["Medicine, University of Maryland at Baltimore , Baltimore, MD","Research Service, VAMHCS , Baltimore, MD","1Medicine, University of Maryland at Baltimore, Baltimore, MD","3Research Service, VAMHCS, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Maryland at Baltimore , Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Research Service, VAMHCS , Baltimore, MD","institution_ids":["https://openalex.org/I4210163125"]},{"raw_affiliation_string":"1Medicine, University of Maryland at Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"3Research Service, VAMHCS, Baltimore, MD","institution_ids":["https://openalex.org/I4210140381","https://openalex.org/I4210163125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063791039","display_name":"Cornelia Diana Cudrici","orcid":"https://orcid.org/0000-0002-9077-8195","observed_orcids":["https://orcid.org/0000-0002-9077-8195"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cornelia Cudrici","raw_affiliation_strings":["NIAMS, NIH , Bethesda, MD","5NIAMS, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAMS, NIH , Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"raw_affiliation_string":"5NIAMS, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039973533","display_name":"Tudor C. Badea","orcid":"https://orcid.org/0000-0003-3086-6713","observed_orcids":["https://orcid.org/0000-0003-3086-6713"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tudor Badea","raw_affiliation_strings":["Retinal Circuit Development and Genetics Unit, NIH- National Eye Institute , Bethesda, MD","4Retinal Circuit Development and Genetics Unit, NIH- National Eye Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Retinal Circuit Development and Genetics Unit, NIH- National Eye Institute , Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"4Retinal Circuit Development and Genetics Unit, NIH- National Eye Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024891879","display_name":"Horea Rus","orcid":"https://orcid.org/0000-0003-2415-5130","observed_orcids":["https://orcid.org/0000-0003-2415-5130"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210140381","display_name":"Baltimore VA Medical Center","ror":"https://ror.org/036a0e562","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210140381","https://openalex.org/I4210163125"]},{"id":"https://openalex.org/I4210163125","display_name":"VA Maryland Health Care System","ror":"https://ror.org/05ax3zh38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210163125"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horea Rus","raw_affiliation_strings":["Neurology, University of Maryland at Baltimore , Baltimore, MD","Research Service, VAMHCS , Baltimore, MD","2Neurology, University of Maryland at Baltimore, Baltimore, MD","3Research Service, VAMHCS, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, University of Maryland at Baltimore , Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Research Service, VAMHCS , Baltimore, MD","institution_ids":["https://openalex.org/I4210163125"]},{"raw_affiliation_string":"2Neurology, University of Maryland at Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"3Research Service, VAMHCS, Baltimore, MD","institution_ids":["https://openalex.org/I4210140381","https://openalex.org/I4210163125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"192","issue":"Supplement_1","first_page":"64.2","last_page":"64.2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgc-32","display_name":"RGC-32","score":0.996999979019165},{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.8930000066757202},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lamina-propria-lymphocytes","display_name":"lamina propria lymphocytes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/th1-cell-differentiation","display_name":"Th1 differentiation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/th2-differentiation","display_name":"Th2 differentiation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/complement-c5b-9","display_name":"complement C5b-9","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5472303628921509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48843446373939514},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4806017577648163},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.46486932039260864},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4319922626018524},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42462143301963806},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4149266183376312},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41474398970603943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3244742751121521},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2188977301120758},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15579092502593994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0749620795249939}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.192.supp.64.2","doi":"https://doi.org/10.4049/jimmunol.192.supp.64.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.64.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2615655533","https://openalex.org/W2955170178","https://openalex.org/W2599077716","https://openalex.org/W1977684358","https://openalex.org/W2899556989","https://openalex.org/W4313386284","https://openalex.org/W1571813216","https://openalex.org/W2035018429","https://openalex.org/W2772222670","https://openalex.org/W4313379436"],"abstract_inverted_index":{"Abstract":[0],"Our":[1],"group":[2],"has":[3],"cloned":[4],"and":[5,18,31,42,50,98,122,125,130,157,161,165,230,237],"characterized":[6],"the":[7,58,191],"Response":[8],"Gene":[9],"to":[10,108,111,149],"Complement":[11],"(RGC)-32":[12],"which":[13],"is":[14,35,221],"induced":[15,51],"by":[16,152,169],"C5b-9":[17],"exerts":[19],"an":[20],"important":[21],"role":[22,45,68],"in":[23,46,69,77,120,128,137,141,145,180,207,228,231],"cell":[24,87,95],"cycle":[25],"activation":[26,30],"via":[27],"cyclin":[28],"B1-CDC2":[29],"Akt":[32],"phosphorylation.":[33],"RGC-32":[34,65,73,80,102,181,208,220],"also":[36],"a":[37,44,67,117,131,222],"downstream":[38],"target":[39],"of":[40,60,134,155,198,225,235],"TGF-\u03b2":[41],"plays":[43,66],"fibrogenesis.":[47],"As":[48],"Th17":[49,112,163,226],"T":[52,86,94,105,184,200],"regulatory":[53],"cells":[54,106,136,185,201,204,213],"(iTreg)":[55],"differentiate":[56,109],"under":[57,162,186],"control":[59],"TGF-\u03b2,":[61],"we":[62,90],"determined":[63],"whether":[64],"this":[70],"process":[71],"using":[72],"KO":[74,103,182,209],"mice":[75,210],"generated":[76],"our":[78],"lab.":[79],"was":[81,166,178,193,205],"not":[82,167,194],"required":[83],"for":[84,174],"peripheral":[85],"homeostasis":[88],"as":[89,114],"observed":[91],"normal":[92],"cellularity,":[93],"subset":[96],"composition":[97],"phenotypic":[99],"markers.":[100],"However,":[101],"CD4+":[104,183,199],"failed":[107],"normally":[110],"lineage":[113],"they":[115],"exhibited":[116],"significant":[118],"reduction":[119],"IL-17":[121,146],"ROR\u03b3t":[123],"mRNA":[124],"protein":[126],"expression":[127,147,154],"vitro":[129,229],"decreased":[132,153,206],"proportion":[133],"IL-17+":[135],"lamina":[138],"propria":[139],"lymphocytes":[140],"vivo.":[142],"The":[143],"defect":[144],"appeared":[148],"be":[150],"mediated":[151],"IL-6R":[156,236],"TGF-\u03b2RI":[158,238],"at":[159],"baseline":[160],"conditions":[164,189],"restored":[168],"IL-2":[170],"inhibition.":[171],"A":[172],"trend":[173],"increased":[175],"iTreg":[176],"differentiation":[177,227],"noted":[179],"Treg":[187],"skewing":[188],"but":[190],"difference":[192],"statistically":[195],"significant.":[196],"Differentiation":[197],"into":[202],"Th1":[203],"while":[211],"Th2":[212],"developed":[214],"normally.":[215],"These":[216],"results":[217],"suggest":[218],"that":[219],"novel":[223],"mediator":[224],"vivo":[232],"through":[233],"modulation":[234],"expression.":[239]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
