{"id":"https://openalex.org/W167676282","doi":null,"title":"An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device","display_name":"An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device","publication_year":2010,"publication_date":"2010-03-28","ids":{"openalex":"https://openalex.org/W167676282","mag":"167676282"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:19562","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/19562/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Amy Thomas","orcid":"https://orcid.org/0000-0002-2658-4126","observed_orcids":["https://orcid.org/0000-0002-2658-4126"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amy Thomas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2658-4126","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.444599986076355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.444599986076355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioartificial-liver","display_name":"bioartificial liver","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/primary-human-hepatocytes","display_name":"primary human hepatocytes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/intestinal-cell-lines","display_name":"intestinal cell lines","score":0.5730000138282776},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/constitutive-androstane-receptor","display_name":"constitutive androstane receptor","score":0.875},{"id":"https://openalex.org/keywords/retinoid-x-receptor-alpha","display_name":"retinoid X receptor alpha","score":0.9779999852180481},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.6460000276565552},{"id":"https://openalex.org/keywords/alginate-encapsulation","display_name":"alginate encapsulation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/chemical-induction","display_name":"chemical induction","score":0.5720000267028809},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C11824378","wikidata":"https://www.wikidata.org/wiki/Q5014970","display_name":"CYP3A","level":4,"score":0.8177000284194946},{"id":"https://openalex.org/C193264327","wikidata":"https://www.wikidata.org/wiki/Q14905078","display_name":"Constitutive androstane receptor","level":5,"score":0.738862156867981},{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.7320373058319092},{"id":"https://openalex.org/C71867830","wikidata":"https://www.wikidata.org/wiki/Q17103308","display_name":"Bioartificial liver device","level":4,"score":0.7196295857429504},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6183677315711975},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.602988600730896},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5394168496131897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4985959529876709},{"id":"https://openalex.org/C195521686","wikidata":"https://www.wikidata.org/wiki/Q17152676","display_name":"Liver cytology","level":3,"score":0.4920060336589813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47032272815704346},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.4682423174381256},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4369380474090576},{"id":"https://openalex.org/C181674461","wikidata":"https://www.wikidata.org/wiki/Q5731621","display_name":"Hep G2","level":3,"score":0.42657071352005005},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.41432899236679077},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39884424209594727},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38024526834487915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35553887486457825},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21038079261779785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2019852101802826},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20157769322395325},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.11308136582374573},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1021241545677185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07526805996894836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:19562","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/19562/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:167676282","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/19562","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":290,"referenced_works":["https://openalex.org/W34051461","https://openalex.org/W101728102","https://openalex.org/W119374870","https://openalex.org/W186154380","https://openalex.org/W1512399997","https://openalex.org/W1544562011","https://openalex.org/W1562445183","https://openalex.org/W1579096574","https://openalex.org/W1603239479","https://openalex.org/W1605785874","https://openalex.org/W1748227957","https://openalex.org/W1766052870","https://openalex.org/W1790932834","https://openalex.org/W1792142249","https://openalex.org/W1822042631","https://openalex.org/W1887243203","https://openalex.org/W1898519536","https://openalex.org/W1909763738","https://openalex.org/W1925943257","https://openalex.org/W1932377803","https://openalex.org/W1935313727","https://openalex.org/W1963815648","https://openalex.org/W1965728190","https://openalex.org/W1966030580","https://openalex.org/W1967251260","https://openalex.org/W1967325600","https://openalex.org/W1967797994","https://openalex.org/W1968535758","https://openalex.org/W1969123181","https://openalex.org/W1970359870","https://openalex.org/W1970444976","https://openalex.org/W1970477136","https://openalex.org/W1970710621","https://openalex.org/W1972078123","https://openalex.org/W1973568753","https://openalex.org/W1974493959","https://openalex.org/W1975516622","https://openalex.org/W1976503445","https://openalex.org/W1977940506","https://openalex.org/W1978228602","https://openalex.org/W1979598672","https://openalex.org/W1979618028","https://openalex.org/W1980184671","https://openalex.org/W1980455299","https://openalex.org/W1981316929","https://openalex.org/W1981630572","https://openalex.org/W1982583749","https://openalex.org/W1983294805","https://openalex.org/W1983549103","https://openalex.org/W1984006635","https://openalex.org/W1984574841","https://openalex.org/W1985137868","https://openalex.org/W1985696642","https://openalex.org/W1987007548","https://openalex.org/W1987184539","https://openalex.org/W1987305426","https://openalex.org/W1988423818","https://openalex.org/W1988875702","https://openalex.org/W1990473863","https://openalex.org/W1990500878","https://openalex.org/W1990563353","https://openalex.org/W1991020267","https://openalex.org/W1991054739","https://openalex.org/W1991274852","https://openalex.org/W1991794684","https://openalex.org/W1992360845","https://openalex.org/W1992366665","https://openalex.org/W1993454872","https://openalex.org/W1993662329","https://openalex.org/W1994405711","https://openalex.org/W1995193342","https://openalex.org/W1995900377","https://openalex.org/W1996695569","https://openalex.org/W1997271604","https://openalex.org/W1998850038","https://openalex.org/W1999362347","https://openalex.org/W2000521374","https://openalex.org/W2000585507","https://openalex.org/W2001008212","https://openalex.org/W2003202516","https://openalex.org/W2003843674","https://openalex.org/W2003909953","https://openalex.org/W2005014916","https://openalex.org/W2005605345","https://openalex.org/W2005845442","https://openalex.org/W2005859923","https://openalex.org/W2005908061","https://openalex.org/W2005914307","https://openalex.org/W2005942951","https://openalex.org/W2006360771","https://openalex.org/W2007615684","https://openalex.org/W2007733439","https://openalex.org/W2008089469","https://openalex.org/W2009330082","https://openalex.org/W2010519104","https://openalex.org/W2011661344","https://openalex.org/W2012441366","https://openalex.org/W2012740041","https://openalex.org/W2013030667","https://openalex.org/W2013594177","https://openalex.org/W2014424798","https://openalex.org/W2014980326","https://openalex.org/W2015021809","https://openalex.org/W2015783622","https://openalex.org/W2016670768","https://openalex.org/W2016799324","https://openalex.org/W2016920671","https://openalex.org/W2020375403","https://openalex.org/W2021019017","https://openalex.org/W2021686544","https://openalex.org/W2022600795","https://openalex.org/W2023879656","https://openalex.org/W2025138648","https://openalex.org/W2026327041","https://openalex.org/W2026993208","https://openalex.org/W2027517951","https://openalex.org/W2027816981","https://openalex.org/W2029562489","https://openalex.org/W2029703893","https://openalex.org/W2034111310","https://openalex.org/W2034424913","https://openalex.org/W2038014794","https://openalex.org/W2039336124","https://openalex.org/W2039343921","https://openalex.org/W2040034984","https://openalex.org/W2040162622","https://openalex.org/W2040546709","https://openalex.org/W2040567225","https://openalex.org/W2044911368","https://openalex.org/W2047258357","https://openalex.org/W2049570891","https://openalex.org/W2049665672","https://openalex.org/W2049770869","https://openalex.org/W2050286038","https://openalex.org/W2052406081","https://openalex.org/W2053810332","https://openalex.org/W2054030734","https://openalex.org/W2054400601","https://openalex.org/W2054565652","https://openalex.org/W2055803253","https://openalex.org/W2056096759","https://openalex.org/W2056361728","https://openalex.org/W2056487043","https://openalex.org/W2056575172","https://openalex.org/W2056813704","https://openalex.org/W2056910223","https://openalex.org/W2057592154","https://openalex.org/W2058082386","https://openalex.org/W2062530492","https://openalex.org/W2062685859","https://openalex.org/W2062861317","https://openalex.org/W2063442560","https://openalex.org/W2063539617","https://openalex.org/W2063968553","https://openalex.org/W2064143920","https://openalex.org/W2065228188","https://openalex.org/W2065936324","https://openalex.org/W2066312456","https://openalex.org/W2068169313","https://openalex.org/W2068537822","https://openalex.org/W2068780263","https://openalex.org/W2069347152","https://openalex.org/W2070611230","https://openalex.org/W2072624946","https://openalex.org/W2073526315","https://openalex.org/W2073602674","https://openalex.org/W2073976519","https://openalex.org/W2074577842","https://openalex.org/W2077331899","https://openalex.org/W2077510076","https://openalex.org/W2077678888","https://openalex.org/W2078024939","https://openalex.org/W2080326544","https://openalex.org/W2081154924","https://openalex.org/W2082353955","https://openalex.org/W2082428499","https://openalex.org/W2082907683","https://openalex.org/W2084011955","https://openalex.org/W2084094816","https://openalex.org/W2085811360","https://openalex.org/W2089231631","https://openalex.org/W2089387410","https://openalex.org/W2090337418","https://openalex.org/W2090933356","https://openalex.org/W2092111972","https://openalex.org/W2093582761","https://openalex.org/W2093919886","https://openalex.org/W2095853592","https://openalex.org/W2096580672","https://openalex.org/W2097675898","https://openalex.org/W2098547087","https://openalex.org/W2098651443","https://openalex.org/W2098720060","https://openalex.org/W2100481402","https://openalex.org/W2100541156","https://openalex.org/W2103020094","https://openalex.org/W2104768583","https://openalex.org/W2105095702","https://openalex.org/W2105791467","https://openalex.org/W2106117327","https://openalex.org/W2106859330","https://openalex.org/W2108352524","https://openalex.org/W2108665729","https://openalex.org/W2108705873","https://openalex.org/W2108765637","https://openalex.org/W2109001578","https://openalex.org/W2112116342","https://openalex.org/W2112614409","https://openalex.org/W2113793088","https://openalex.org/W2114733829","https://openalex.org/W2115386094","https://openalex.org/W2116418471","https://openalex.org/W2116635252","https://openalex.org/W2116638233","https://openalex.org/W2119636014","https://openalex.org/W2119678057","https://openalex.org/W2121362847","https://openalex.org/W2122126544","https://openalex.org/W2122314449","https://openalex.org/W2122742700","https://openalex.org/W2123063654","https://openalex.org/W2123081876","https://openalex.org/W2125767380","https://openalex.org/W2128157627","https://openalex.org/W2128401222","https://openalex.org/W2129277308","https://openalex.org/W2130093373","https://openalex.org/W2130341652","https://openalex.org/W2130766675","https://openalex.org/W2132083523","https://openalex.org/W2132086750","https://openalex.org/W2132464767","https://openalex.org/W2133659369","https://openalex.org/W2134579258","https://openalex.org/W2135285043","https://openalex.org/W2135711414","https://openalex.org/W2136869792","https://openalex.org/W2137468287","https://openalex.org/W2137996903","https://openalex.org/W2138133935","https://openalex.org/W2138874759","https://openalex.org/W2139078612","https://openalex.org/W2142406561","https://openalex.org/W2143926676","https://openalex.org/W2146175374","https://openalex.org/W2146713276","https://openalex.org/W2147998260","https://openalex.org/W2148083393","https://openalex.org/W2148779101","https://openalex.org/W2153252326","https://openalex.org/W2153328625","https://openalex.org/W2153681048","https://openalex.org/W2154015838","https://openalex.org/W2155335820","https://openalex.org/W2156996385","https://openalex.org/W2157207950","https://openalex.org/W2158671268","https://openalex.org/W2159373818","https://openalex.org/W2159479834","https://openalex.org/W2161109243","https://openalex.org/W2161835881","https://openalex.org/W2162338844","https://openalex.org/W2163588607","https://openalex.org/W2163891284","https://openalex.org/W2165086054","https://openalex.org/W2165165683","https://openalex.org/W2165484971","https://openalex.org/W2165731382","https://openalex.org/W2166279203","https://openalex.org/W2167194617","https://openalex.org/W2168336351","https://openalex.org/W2169345846","https://openalex.org/W2171097190","https://openalex.org/W2171317636","https://openalex.org/W2171342967","https://openalex.org/W2171534546","https://openalex.org/W2187718168","https://openalex.org/W2187922517","https://openalex.org/W2199631211","https://openalex.org/W2246028378","https://openalex.org/W2284613906","https://openalex.org/W2320205740","https://openalex.org/W2336139768","https://openalex.org/W2402304833","https://openalex.org/W2411333350","https://openalex.org/W2413121399","https://openalex.org/W2414865629","https://openalex.org/W2415954795","https://openalex.org/W2416556234","https://openalex.org/W2605614532"],"related_works":["https://openalex.org/W2460768830","https://openalex.org/W1994381178","https://openalex.org/W2788142733","https://openalex.org/W2010940895","https://openalex.org/W2029006016","https://openalex.org/W2030406704","https://openalex.org/W2980103790","https://openalex.org/W1991500021","https://openalex.org/W2287058607","https://openalex.org/W2145124129"],"abstract_inverted_index":{"Bioartificial":[0],"Liver":[1],"Devices":[2],"(BAL)":[3],"could":[4],"provide":[5,59,133,159,294],"hepatic":[6,87],"function":[7,72,113,183,234,240,252,268,296],"in":[8,62,77,169,226,232,248,261],"patients":[9],"with":[10,228],"liver":[11,16],"\\nfailure":[12],"awaiting":[13],"transplantation":[14],"or":[15],"regeneration.":[17],"Certain":[18],"BALs":[19],"use":[20],"human":[21,100],"\\nhepatoblastoma-derived":[22],"HepG2":[23,78,128,202,265],"cells":[24,79,129],"that":[25,279],"can":[26],"perform":[27],"many":[28],"hepatocyte":[29,148],"specific":[30,171],"\\nfunctions,":[31],"however":[32],"they":[33],"cannot":[34],"adequately":[35],"detoxify":[36],"xenobiotics":[37],"via":[38],"Cytochrome":[39],"P450":[40],"\\n(CYP)":[41],"mediated":[42],"pathways.":[43],"\\nThe":[44,198],"aim":[45],"of":[46,96,107,200,204,235,253,282],"this":[47],"thesis":[48],"was":[49,184,196,241,258,269,277],"to":[50,58,86,132,158,167,243,272,293],"identify":[51],"and":[52,65,80,90,124,144,146,211,285],"develop":[53],"a":[54,63,174,219,254,298],"cell":[55,141,150,188,266],"source":[56],"able":[57,131],"CYP":[60,88,112,237,267,295],"\\nfunction":[61],"BAL,":[64],"focused":[66],"on":[67,111],"CYP1A2,":[68],"since":[69],"its":[70,83],"inducible":[71],"has":[73],"been":[74],"well":[75],"\\nestablished":[76],"CYP3A":[81,138,160,182,239,251],"due":[82],"large":[84],"contribution":[85],"\\nexpression":[89],"function.":[91,139,162],"\\nFirstly,":[92],"gold":[93],"standard":[94],"comparators":[95],"freshly":[97],"isolated":[98],"primary":[99],"hepatocytes":[101],"\\n(PHH)":[102],"were":[103,130,153,165,216],"established.":[104],"The":[105],"influence":[106],"BAL":[108,161,170,195],"culture":[109,119,176,283],"conditions":[110,284],"\\nwere":[114],"evaluated,":[115],"including":[116],"chemical":[117,229],"induction,":[118,230],"media":[120],"composition,":[121],"alginate":[122],"\\nencapsulation":[123],"microgravity":[125],"3D":[126,175,262],"culture:":[127],"sufficient":[134],"\\nCYP1A2":[135],"but":[136,190],"limited":[137],"\\nIntestinal":[140],"lines":[142],"LS147T":[143],"Caco2":[145],"the":[147,291],"derived":[149],"line":[151],"HC-04":[152],"\\ninvestigated":[154],"as":[155],"potential":[156,292],"sources":[157],"All":[163],"three":[164],"\\nshown":[166],"proliferate":[168],"medium":[172],"within":[173,193,297],"system.":[177],"Under":[178],"these":[179,288],"\\nconditions,":[180],"increased":[181,222],"demonstrated":[185,260],"for":[186],"each":[187],"line,":[189],"their":[191],"\\nusefulness":[192],"our":[194],"limited.":[197],"effects":[199],"increasing":[201],"expression":[203],"two":[205],"nuclear":[206,223],"receptors":[207],"(Constitutive":[208],"\\nAndrostane":[209],"Receptor":[210,214],"Retinoid":[212],"X":[213],"\u03b1)":[215],"examined.":[217],"Within":[218],"transient":[220],"\\nsystem,":[221],"receptor":[224],"expression,":[225],"conjunction":[227],"\\nresulted":[231],"improved":[233],"multiple":[236],"isoforms;":[238],"\\nincreased":[242],"levels":[244],"approaching":[245],"those":[246],"measured":[247],"PHH.":[249],"Inducible":[250],"\\nstable":[255],"CAR":[256],"transfectant":[257],"then":[259],"culture.":[263],"\\nLastly":[264],"also":[270],"shown":[271],"be":[273],"source-dependent.":[274],"Overall":[275],"it":[276],"\\nconcluded":[278],"through":[280],"adaptation":[281],"genetic":[286],"manipulation,":[287],"\\ncells":[289],"have":[290],"BAL.":[299]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
