{"id":"https://openalex.org/W167647799","doi":null,"title":"Newand Rapid Functional Assay for Cl Inhibitor in Human Plasma","display_name":"Newand Rapid Functional Assay for Cl Inhibitor in Human Plasma","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W167647799","mag":"167647799"},"language":"en","primary_location":{"id":"mag:167647799","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Robert_Colman2/publication/17015454_New_and_rapid_functional_assay_for_C1_inhibitor_in_human_plasma/links/00b495397b9d223fd8000000.pdf?disableCoverPage=true","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113764302","display_name":"RW Colman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RW Colman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008948102","display_name":"Marc Schapira","orcid":"https://orcid.org/0000-0003-0384-0075","observed_orcids":["https://orcid.org/0000-0003-0384-0075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Schapira","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0384-0075","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003868834","display_name":"Lee D. Silver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Silver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438465","display_name":"Cheryl F. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheryl F. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00994517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.8600000143051147},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.949999988079071},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.6740000247955322},{"id":"https://openalex.org/keywords/functional-assays","display_name":"functional assays","score":0.6179999709129333},{"id":"https://openalex.org/keywords/plasma-kininogen","display_name":"plasma kininogen","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.944966197013855},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.8968716859817505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8524436354637146},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.6844714283943176},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.5794211030006409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42500829696655273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4091534912586212},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.19658604264259338}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:167647799","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Robert_Colman2/publication/17015454_New_and_rapid_functional_assay_for_C1_inhibitor_in_human_plasma/links/00b495397b9d223fd8000000.pdf?disableCoverPage=true","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1497280552","https://openalex.org/W1519265737","https://openalex.org/W1522956225","https://openalex.org/W1565096783","https://openalex.org/W1586104616","https://openalex.org/W1964747434","https://openalex.org/W1971508361","https://openalex.org/W1985484598","https://openalex.org/W2025562266","https://openalex.org/W2034405640","https://openalex.org/W2047011884","https://openalex.org/W2064958205","https://openalex.org/W2065141688","https://openalex.org/W2078264642","https://openalex.org/W2089682872","https://openalex.org/W2102613564","https://openalex.org/W2213618112","https://openalex.org/W2321234878","https://openalex.org/W2418890709"],"related_works":["https://openalex.org/W1868691364","https://openalex.org/W1985484598","https://openalex.org/W2883987660","https://openalex.org/W2409799785","https://openalex.org/W2023046997","https://openalex.org/W2014720148","https://openalex.org/W2012663405","https://openalex.org/W2065141688","https://openalex.org/W2884876711","https://openalex.org/W2007516346"],"abstract_inverted_index":{"c":[0],"i\u2019":[1],"inhibitor":[2,85],"(Ci-INH)":[3],"and":[4,61],"a2-macroglobulin":[5],"(a2M)":[6],"account":[7],"for":[8,94],"over":[9],"90%":[10],"of":[11,14,24,33,50,66,72,97],"the":[12,31,47,51,63,70,90,95],"inactivation":[13,26,71,96],"purified":[15],"plasma":[16,75],"kallikrein":[17,25,45,73],"by":[18,68,74,88],"normal":[19],"human":[20],"plasma.":[21],"The":[22],"rate":[23,92],"is":[27],"also":[28],"dependent":[29,79],"on":[30,80],"presence":[32],"high":[34],"molecular":[35],"weight":[36],"kininogen":[37],"(HMWK).":[38],"which":[39],"forms":[40],"a":[41],"reversible":[42],"complex":[43],"with":[44,59],"protecting":[46],"active":[48],"site":[49],"enzyme":[52],"against":[53],"inhibitors.":[54],"By":[55],"selectively":[56],"mactivating":[57],"a2M":[58],"methylamine.":[60],"eliminating":[62],"protective":[64],"effect":[65],"HMWK":[67],"dilution.":[69],"became":[76],"almost":[77],"exclusively":[78],"Cl":[81],"-INH.":[82],"Functional":[83],"Ci":[84],"was":[86],"assessed":[87],"measuring":[89],"pseudo-first-order":[91],"constant":[93]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}