{"id":"https://openalex.org/W167582018","doi":"https://doi.org/10.1152/ajpcell.1989.256.4.c786","title":"Intracellular Na+ regulation of Na+ pump sites in cultured vascular smooth muscle cells","display_name":"Intracellular Na+ regulation of Na+ pump sites in cultured vascular smooth muscle cells","publication_year":1989,"publication_date":"1989-04-01","ids":{"openalex":"https://openalex.org/W167582018","doi":"https://doi.org/10.1152/ajpcell.1989.256.4.c786","mag":"167582018","pmid":"https://pubmed.ncbi.nlm.nih.gov/2539727"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1989.256.4.c786","doi":"https://doi.org/10.1152/ajpcell.1989.256.4.c786","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1989.256.4.c786","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. C. Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Allen","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019743789","display_name":"Stephen S. Navran","orcid":"https://orcid.org/0000-0002-1038-3071","observed_orcids":["https://orcid.org/0000-0002-1038-3071"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Navran","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108592565","display_name":"C L Seidel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. L. Seidel","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. K. Dennison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. K. Dennison","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793371","display_name":"Joseph M. Amann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Amann","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021817106","display_name":"S. Jemelka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. K. Jemelka","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine, Houston, Texas77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, Texas77030","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":1.0316,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.74740752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"256","issue":"4","first_page":"C786","last_page":"C792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/intracellular-sodium","display_name":"intracellular sodium","score":0.902999997138977},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ouabain-binding","display_name":"ouabain binding","score":0.824999988079071},{"id":"https://openalex.org/keywords/fetal-bovine-serum","display_name":"fetal bovine serum","score":0.6790000200271606},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/sodium-influx","display_name":"sodium influx","score":0.7680000066757202},{"id":"https://openalex.org/keywords/saphenous-vein","display_name":"saphenous vein","score":0.7799999713897705},{"id":"https://openalex.org/keywords/femoral-artery","display_name":"femoral artery","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7658306360244751},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.7453212738037109},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6044187545776367},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5783600211143494},{"id":"https://openalex.org/C39271989","wikidata":"https://www.wikidata.org/wiki/Q649056","display_name":"Diaphragm pump","level":3,"score":0.5234332084655762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47201985120773315},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4578586518764496},{"id":"https://openalex.org/C2779404806","wikidata":"https://www.wikidata.org/wiki/Q488614","display_name":"Fetal bovine serum","level":3,"score":0.4428372085094452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4158726930618286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.370958149433136},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32091647386550903},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.299542635679245},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.2902148962020874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2580215334892273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18726542592048645},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06370490789413452},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C76272257","wikidata":"https://www.wikidata.org/wiki/Q1933964","display_name":"Micropump","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005263","descriptor_name":"Femoral Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012414","descriptor_name":"Rubidium Radioisotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012501","descriptor_name":"Saphenous Vein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1989.256.4.c786","doi":"https://doi.org/10.1152/ajpcell.1989.256.4.c786","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1989.256.4.c786","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:2539727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2539727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1383689268","display_name":null,"funder_award_id":"HL-37391","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G33092041","display_name":null,"funder_award_id":"HL 34280","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4134963375","display_name":null,"funder_award_id":"HL-23815","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1975089277","https://openalex.org/W1977379434","https://openalex.org/W1982990417","https://openalex.org/W1992472345","https://openalex.org/W1997320114","https://openalex.org/W2001766548","https://openalex.org/W2008609946","https://openalex.org/W2043813981","https://openalex.org/W2048249544","https://openalex.org/W2063053759","https://openalex.org/W2079717243","https://openalex.org/W2082269897","https://openalex.org/W2128623551","https://openalex.org/W2158979977","https://openalex.org/W2257328336"],"related_works":["https://openalex.org/W2412420976","https://openalex.org/W2233243860","https://openalex.org/W2414502329","https://openalex.org/W2412336743","https://openalex.org/W2077465227","https://openalex.org/W2415634050","https://openalex.org/W2411274737","https://openalex.org/W2072974000","https://openalex.org/W1966128887","https://openalex.org/W2120854470"],"abstract_inverted_index":{"Enzymatically":[0],"dispersed":[1],"cells":[2,117,157],"from":[3],"canine":[4],"saphenous":[5],"vein":[6],"and":[7,16,44,66,111,129,167],"femoral":[8],"artery":[9],"were":[10,37],"grown":[11],"in":[12,25,42,95,107,120,186],"fetal":[13,124,159],"calf":[14,125,160],"serum":[15,161],"studied":[17],"at":[18,73],"day":[19,64],"0":[20],"(freshly":[21],"dispersed)":[22],"through":[23,63],"confluence":[24],"primary":[26],"culture.":[27],"Intracellular":[28],"Na":[29],"levels":[30],"(Nai),":[31],"but":[32],"not":[33,137],"intracellular":[34],"K":[35],"(Ki),":[36],"increased":[38,62,164],"after":[39],"24":[40],"h":[41],"culture":[43],"then":[45],"decreased":[46],"to":[47,83,158,194],"a":[48,168,184],"steady":[49],"state":[50],"by":[51,172],"4":[52],"days.":[53],"Na+":[54,78,96,165,174],"pump":[55,79,86,97,175,181],"site":[56,80,98],"number":[57,81,131],"[(":[58],"3H]":[59],"ouabain":[60],"binding)":[61],"3":[65],"remained":[67],"elevated.":[68],"Nai":[69,169],"was":[70],"still":[71],"elevated":[72],"2":[74],"days":[75],"when":[76],"the":[77,93,104,115,130,146,149,187],"began":[82],"increase.":[84],"Total":[85],"turnover":[87],"(maximum":[88],"ouabain-inhibited":[89],"86Rb":[90],"uptake)":[91],"reflected":[92],"increase":[94],"number.":[99],"These":[100,141],"key":[101],"events":[102],"precede":[103],"observed":[105],"increases":[106],"both":[108],"protein":[109],"production":[110],"cellular":[112],"proliferation.":[113,196],"If":[114],"same":[116],"are":[118,143],"maintained":[119],"defined":[121],"medium,":[122],"without":[123],"serum,":[126],"Nai,":[127,189],"Ki,":[128],"of":[132,153,179],"[3H]ouabain":[133],"binding":[134],"sites":[135,182],"do":[136],"change":[138],"with":[139,145],"time.":[140],"data":[142],"consistent":[144],"suggestion":[147],"that":[148],"initial":[150],"mitogenic":[151],"response":[152],"vascular":[154],"smooth":[155],"muscle":[156],"involves":[162],"an":[163],"influx,":[166],"accumulation,":[170],"caused":[171],"low":[173],"density.":[176],"The":[177],"synthesis":[178],"new":[180],"effects":[183],"decrease":[185],"accumulated":[188],"which":[190],"may":[191],"be":[192],"related":[193],"cell":[195]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
