{"id":"https://openalex.org/W16755528","doi":null,"title":"Advancements of stem-cell therapy for type 1 diabetes mellitus","display_name":"Advancements of stem-cell therapy for type 1 diabetes mellitus","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W16755528","mag":"16755528"},"language":"en","primary_location":{"id":"mag:16755528","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SMKX200704009.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764901949","display_name":"Shengming kexue","issn_l":"1004-0374","issn":["1004-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4360969379","host_organization_name":"National Natural Science Foundation of China","host_organization_lineage":["https://openalex.org/P4360969379"],"host_organization_lineage_names":["National Natural Science Foundation of China"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shengming kexue","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103104552","display_name":"Hongdan Li","orcid":"https://orcid.org/0000-0002-3676-4577","observed_orcids":["https://orcid.org/0000-0002-3676-4577"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongdan Li","raw_affiliation_strings":["Liaoning Medical College,Jinzhou 121001,China)"],"raw_orcid":"https://orcid.org/0000-0002-3676-4577","affiliations":[{"raw_affiliation_string":"Liaoning Medical College,Jinzhou 121001,China)","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Ping Jia","orcid":"https://orcid.org/0000-0002-3739-8994","observed_orcids":["https://orcid.org/0000-0002-3739-8994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3739-8994","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103104552"],"corresponding_institution_ids":["https://openalex.org/I85430964"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00324032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.875},{"id":"https://openalex.org/keywords/pancreatic-beta-cell-regeneration","display_name":"pancreatic beta-cell regeneration","score":0.7609999775886536},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/immunocompatibility","display_name":"immunocompatibility","score":0.625},{"id":"https://openalex.org/keywords/tumor-formation","display_name":"tumor formation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/autoimmune-beta-cell-destruction","display_name":"autoimmune beta-cell destruction","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7429888248443604},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7019875049591064},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5740939974784851},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.5511929988861084},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5406299829483032},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5267704725265503},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.521699845790863},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5044621229171753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4874570369720459},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48654595017433167},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.47091174125671387},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4603116512298584},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4534688889980316},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45339491963386536},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4288312792778015},{"id":"https://openalex.org/C143441281","wikidata":"https://www.wikidata.org/wiki/Q5133858","display_name":"Clinical uses of mesenchymal stem cells","level":5,"score":0.42137253284454346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3739693760871887},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37357449531555176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32624733448028564},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2989494800567627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2681920528411865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:16755528","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SMKX200704009.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764901949","display_name":"Shengming kexue","issn_l":"1004-0374","issn":["1004-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4360969379","host_organization_name":"National Natural Science Foundation of China","host_organization_lineage":["https://openalex.org/P4360969379"],"host_organization_lineage_names":["National Natural Science Foundation of China"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shengming kexue","raw_type":null},{"id":"mag:2987814716","doi":null,"is_oa":false,"landing_page_url":"https://www.bioon.com/biology/UploadFiles/200709/20070925104937777.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8315142516","display_name":"STATISTICAL METHODS IN AIDS RESEARCH","funder_award_id":"R01AI029196","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000862605","display_name":"University of Michigan Rogel Cancer Center Support Grant 2023-2028","funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W171578870","https://openalex.org/W1982022033","https://openalex.org/W1993902386","https://openalex.org/W1997470313","https://openalex.org/W2023842938","https://openalex.org/W2024307514","https://openalex.org/W2039508080","https://openalex.org/W2046703988","https://openalex.org/W2047063964","https://openalex.org/W2054361177","https://openalex.org/W2061208107","https://openalex.org/W2063733864","https://openalex.org/W2069819213","https://openalex.org/W2076770967","https://openalex.org/W2078003843","https://openalex.org/W2079733011","https://openalex.org/W2095404435","https://openalex.org/W2096091265","https://openalex.org/W2102897862","https://openalex.org/W2102915416","https://openalex.org/W2104269891","https://openalex.org/W2123158227","https://openalex.org/W2126792448","https://openalex.org/W2134045039","https://openalex.org/W2134451319","https://openalex.org/W2143359570","https://openalex.org/W2146383332","https://openalex.org/W2155530993","https://openalex.org/W2168448946","https://openalex.org/W2169071674","https://openalex.org/W2328786770","https://openalex.org/W2442590299","https://openalex.org/W2469343808","https://openalex.org/W2598336415"],"related_works":["https://openalex.org/W2139607316","https://openalex.org/W2166814643","https://openalex.org/W2082451483","https://openalex.org/W1911808314","https://openalex.org/W3042191807","https://openalex.org/W2105161581","https://openalex.org/W2915754469","https://openalex.org/W1965512016","https://openalex.org/W2351723728","https://openalex.org/W2328821869"],"abstract_inverted_index":{"Type":[0],"1":[1,162],"diabetes":[2,93,163],"is":[3],"characterized":[4],"by":[5,13,20,26],"the":[6,48,57,111,125,129,138,167,177],"selective":[7],"destruction":[8],"of":[9,17,36,113,156,170],"pancreatic":[10,122],"\u03b2-cells":[11,19],"caused":[12],"an":[14],"autoimmune":[15],"attack.Restoration":[16],"damaged":[18],"transplantation":[21,158],"from":[22,61,83,149],"exogenous":[23],"sources":[24],"or":[25],"endocrine":[27],"pancreas":[28],"regeneration":[29],"would":[30],"be":[31,56,67,100],"ideal":[32],"therapeutic":[33],"options.Stem":[34],"cells":[35,54,65,81,85,148,175],"both":[37],"embryonic":[38,150],"and":[39,132,151,165,176],"adult":[40,152],"origin":[41],"offer":[42],"some":[43],"interesting":[44],"alternatives,taking":[45],"into":[46],"account":[47],"latest":[49],"advances":[50],"indicating":[51],"that":[52,79,141],"these":[53,173],"could":[55,66],"potential":[58],"building":[59],"blocks":[60],"which":[62],"insulin":[63],"secreting":[64],"obtained":[68],"in":[69,94],"vitro":[70],"under":[71],"appropriate":[72],"culture":[73],"conditions.Although":[74],"it":[75],"has":[76],"been":[77,87,143],"reported":[78],"insulin-producing":[80,147],"derived":[82],"stem":[84,153,174],"have":[86,142],"shown":[88],"to":[89,99,110,121,124,145],"reverse":[90],"experimentally":[91],"induced":[92],"animal":[95],"models,several":[96],"concerns":[97],"need":[98],"solved":[101],"before":[102],"finding":[103],"a":[104,114],"definite":[105],"medical":[106],"application.These":[107],"refer":[108],"mainly":[109],"obtainment":[112],"cell":[115,157],"population":[116],"as":[117,119],"similar":[118],"possible":[120,178],"\u03b2-cells,and":[123],"problems":[126,169],"related":[127],"with":[128,172],"immune":[130],"compatibility":[131],"tumor":[133],"formation.This":[134],"review":[135],"will":[136],"describe":[137],"different":[139],"approaches":[140],"used":[144],"obtain":[146],"cells,the":[154],"effect":[155],"for":[159],"treating":[160],"type":[161],"mellitus":[164],"analyze":[166],"main":[168],"therapy":[171],"solving":[179],"methods.":[180]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}