{"id":"https://openalex.org/W1674770932","doi":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","title":"Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells)","display_name":"Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells)","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W1674770932","doi":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","mag":"1674770932","pmid":"https://pubmed.ncbi.nlm.nih.gov/9221771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6573204"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.17-15-05726.1997","doi":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","pdf_url":"https://www.jneurosci.org/content/jneuro/17/15/5726.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/17/15/5726.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008405703","display_name":"Sandra E. Merrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra E. Merrick","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research,  The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research,  The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Q. Trojanowski","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research,  The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research,  The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M.-Y. Lee","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research,  The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research,  The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":4.121,"has_fulltext":true,"cited_by_count":143,"citation_normalized_percentile":{"value":0.9406204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"15","first_page":"5726","last_page":"5737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8679999709129333},{"id":"https://openalex.org/keywords/paired-helical-filaments","display_name":"paired helical filaments","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.8289999961853027},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.8930000066757202},{"id":"https://openalex.org/keywords/calyculin-a","display_name":"calyculin A","score":0.9079999923706055},{"id":"https://openalex.org/keywords/microtubule-depolymerization","display_name":"microtubule depolymerization","score":0.921999990940094},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C177738377","wikidata":"https://www.wikidata.org/wiki/Q7683003","display_name":"Tangle","level":2,"score":0.64315265417099},{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.5870741009712219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5841701626777649},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.5777943134307861},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5680742263793945},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5329675674438477},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5302773714065552},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.5118224024772644},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4713513255119324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45943209528923035},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.43677639961242676},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.43086469173431396},{"id":"https://openalex.org/C2779721402","wikidata":"https://www.wikidata.org/wiki/Q767442","display_name":"Neurofibrillary tangle","level":5,"score":0.42888081073760986},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4145168960094452},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33049336075782776},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.13626772165298462},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.10423538088798523},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06532469391822815},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0624365508556366},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019319","descriptor_name":"Okadaic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.17-15-05726.1997","doi":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","pdf_url":"https://www.jneurosci.org/content/jneuro/17/15/5726.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5763333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6573204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6573204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6573204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:9221771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9221771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.7196","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/17/15/5726.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.17-15-05726.1997","doi":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.17-15-05726.1997","pdf_url":"https://www.jneurosci.org/content/jneuro/17/15/5726.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1674770932.pdf","grobid_xml":"https://content.openalex.org/works/W1674770932.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1481130297","https://openalex.org/W1482198038","https://openalex.org/W1508227800","https://openalex.org/W1532265037","https://openalex.org/W1540826485","https://openalex.org/W1548306676","https://openalex.org/W1573751470","https://openalex.org/W1598318710","https://openalex.org/W1749352888","https://openalex.org/W1776914999","https://openalex.org/W1795525374","https://openalex.org/W1844648396","https://openalex.org/W1958842451","https://openalex.org/W1965232330","https://openalex.org/W1966412214","https://openalex.org/W1966614543","https://openalex.org/W1966975951","https://openalex.org/W1973774127","https://openalex.org/W1975040221","https://openalex.org/W1978668412","https://openalex.org/W1984482388","https://openalex.org/W1984972991","https://openalex.org/W1995515835","https://openalex.org/W1995746467","https://openalex.org/W2002364511","https://openalex.org/W2007824057","https://openalex.org/W2016877136","https://openalex.org/W2021271933","https://openalex.org/W2024815270","https://openalex.org/W2027331854","https://openalex.org/W2032342779","https://openalex.org/W2033004578","https://openalex.org/W2037426608","https://openalex.org/W2049992970","https://openalex.org/W2050998289","https://openalex.org/W2053121988","https://openalex.org/W2055433327","https://openalex.org/W2059667498","https://openalex.org/W2065385034","https://openalex.org/W2066578425","https://openalex.org/W2067299834","https://openalex.org/W2070971554","https://openalex.org/W2078525459","https://openalex.org/W2082429191","https://openalex.org/W2084345288","https://openalex.org/W2099463388","https://openalex.org/W2102701929","https://openalex.org/W2106104578","https://openalex.org/W2116170706","https://openalex.org/W2119361029","https://openalex.org/W2125835860","https://openalex.org/W2131954429","https://openalex.org/W2133128874","https://openalex.org/W2135476883","https://openalex.org/W2142193899","https://openalex.org/W2142626546","https://openalex.org/W2148327308","https://openalex.org/W2155768517","https://openalex.org/W2417605121","https://openalex.org/W2442275722","https://openalex.org/W2504112076","https://openalex.org/W6716932473"],"related_works":["https://openalex.org/W1664805792","https://openalex.org/W2027331854","https://openalex.org/W338120255","https://openalex.org/W2064469555","https://openalex.org/W2107809168","https://openalex.org/W2036504274","https://openalex.org/W2054814745","https://openalex.org/W2111066733","https://openalex.org/W2148984562","https://openalex.org/W94596942"],"abstract_inverted_index":{"Paired":[0],"helical":[1],"filaments":[2],"(PHFs)":[3],"in":[4,9,38,77,136,146,164,175,187,195,202],"the":[5,30,52,103,112,119,128,137,147,165,179,188,196,203],"neurofibrillary":[6],"tangles":[7],"(NFTs)":[8],"Alzheimer's":[10],"disease":[11],"(AD)":[12],"brains":[13,40],"are":[14,36,134],"composed":[15],"of":[16,20,32,47,54,92,105,131,149,152,173,178,190,198,205],"highly":[17],"phosphorylated":[18],"isoforms":[19],"tau":[21,35,100,106,192],"(PHFtau)":[22],"that":[23,171],"fail":[24],"to":[25,107,127],"bind":[26],"microtubules":[27],"(MTs),":[28],"and":[29,75,87,97,109,142,201],"levels":[31],"MT-binding":[33],"competent":[34],"decreased":[37,102],"AD":[39,56,180],"with":[41,95,162],"abundant":[42],"PHFtau.":[43],"Because":[44],"this":[45,125,150],"loss":[46],"MT":[48],"binding":[49,104],"could":[50,66],"compromise":[51],"viability":[53],"tangle-bearing":[55,209],"neurons":[57,80,177],"by":[58,69],"destabilizing":[59],"MTs,":[60,108,141,200],"we":[61],"asked":[62],"whether":[63],"these":[64],"events":[65,153],"be":[67],"initiated":[68],"inhibiting":[70],"protein":[71],"phosphatase":[72],"1":[73],"(PP1)":[74],"PP2A":[76,143,155,174],"cultured":[78],"human":[79],"(NT2N":[81],"cells)":[82],"using":[83],"okadaic":[84],"acid":[85],"(OK)":[86],"calyculin-A":[88],"(CL-A).":[89],"The":[90],"treatment":[91],"NT2N":[93,166],"cells":[94],"OK":[96],"CL-A":[98],"increased":[99],"phosphorylation,":[101],"selectively":[110],"depolymerized":[111],"more":[113,120,138],"stable":[114,139,199],"detyrosinated":[115,140],"MTs":[116,163],"but":[117,156],"not":[118,157],"labile":[121],"tyrosinated":[122],"MTs.":[123],"Significantly,":[124],"led":[126],"rapid":[129],"degeneration":[130,204],"axons,":[132],"which":[133],"enriched":[135],"was":[144,159],"implicated":[145],"initiation":[148],"cascade":[151],"because":[154],"PP1":[158],"closely":[160],"associated":[161],"cells.":[167],"These":[168],"studies":[169],"imply":[170],"inactivation":[172],"vulnerable":[176],"brain":[181],"may":[182],"play":[183],"a":[184],"mechanistic":[185],"role":[186],"conversion":[189],"normal":[191],"into":[193],"PHFtau,":[194],"depolymerization":[197],"axons":[206],"emanating":[207],"from":[208],"neurons.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
