{"id":"https://openalex.org/W1674591978","doi":null,"title":"Biodistribution of indium-111-labeled OC 125 monoclonal antibody intraperitoneally injected into patients operated on for ovarian carcinomas.","display_name":"Biodistribution of indium-111-labeled OC 125 monoclonal antibody intraperitoneally injected into patients operated on for ovarian carcinomas.","publication_year":1989,"publication_date":"1989-06-01","ids":{"openalex":"https://openalex.org/W1674591978","mag":"1674591978","pmid":"https://pubmed.ncbi.nlm.nih.gov/2720667"},"language":"en","primary_location":{"id":"pmid:2720667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2720667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111629101","display_name":"Jean\u2010Fran\u00e7ois Chatal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J F Chatal","raw_affiliation_strings":["Unit\u00e9 211 INSERM, Facult\u00e9 de M\u00e9decine, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 211 INSERM, Facult\u00e9 de M\u00e9decine, Nantes, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109154047","display_name":"Jean Claude Saccavini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Saccavini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048378231","display_name":"Jean\u2010Fran\u00e7ois Gestin","orcid":"https://orcid.org/0000-0002-2804-473X","observed_orcids":["https://orcid.org/0000-0002-2804-473X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Gestin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079924896","display_name":"Philippe Th\u00e9drez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Th\u00e9drez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079494082","display_name":"Chantal Curtet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Curtet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110396947","display_name":"Mireille Kremer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kremer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082078040","display_name":"Dominique Guerreau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Guerreau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079740786","display_name":"Daniel Nolibe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Nolib\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012804079","display_name":"P. Fumoleau","orcid":"https://orcid.org/0000-0002-2912-2170","observed_orcids":["https://orcid.org/0000-0002-2912-2170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Fumoleau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040564661","display_name":"Y Guillard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Guillard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.4773,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.9829415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"49","issue":"11","first_page":"3087","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/111in","display_name":"indium-111","score":0.949999988079071},{"id":"https://openalex.org/keywords/antibody-biodistribution","display_name":"antibody biodistribution","score":0.5960000157356262},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.7400000095367432},{"id":"https://openalex.org/keywords/f-ab-2-fragments","display_name":"F(ab')2 fragments","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-fragments","display_name":"tumor fragments","score":0.4359999895095825},{"id":"https://openalex.org/keywords/tumor-nodules","display_name":"tumor nodules","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tumor-to-normal-tissue-ratio","display_name":"tumor-to-normal tissue ratio","score":0.9110000133514404},{"id":"https://openalex.org/keywords/intraperitoneal-injection","display_name":"intraperitoneal injection","score":0.7870000004768372},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7175193428993225},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.6337188482284546},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.5918511152267456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5004863739013672},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44896626472473145},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.421167254447937},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3886588215827942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3632940649986267},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3603188991546631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24894103407859802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14351114630699158},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09627211093902588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007128","descriptor_name":"Immunoglobulin Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007128","descriptor_name":"Immunoglobulin Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2720667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2720667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1674591978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2720667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132067908","https://openalex.org/W2465239329","https://openalex.org/W2062781010","https://openalex.org/W1976089991","https://openalex.org/W2344143449","https://openalex.org/W2040807343","https://openalex.org/W2007084874","https://openalex.org/W2092585194","https://openalex.org/W85982057","https://openalex.org/W2183239792"],"abstract_inverted_index":{"The":[0,71],"biodistribution":[1],"of":[2,54,66,144,180],"111In-labeled":[3,29,38,46,67],"monoclonal":[4],"antibody":[5,239],"(MAb)":[6],"OC":[7,30,47,68,195],"125":[8,31,48,69,196],"was":[9,118,139,188],"studied":[10],"after":[11,80],"i.p.":[12,81],"injection":[13],"in":[14,95],"28":[15],"patients":[16,72],"who":[17],"underwent":[18],"surgery":[19],"for":[20,128,135,167,185,207,215,238],"ovarian":[21],"carcinoma.":[22],"Group":[23,33,41,60,129,136,145,151,168,186],"I":[24,130],"(eight":[25],"patients)":[26,36,44,63],"received":[27],"intact":[28,37,45],"MAb,":[32],"II":[34,146],"(three":[35],"irrelevant":[39],"NS,":[40],"III":[42,152],"(five":[43],"MAb":[49,58,197],"associated":[50],"with":[51,176,194],"20":[52],"mg":[53],"the":[55,84,99],"same":[56],"unlabeled":[57],"and":[59,83,131,150,170,205,211,213,219],"IV":[61],"(12":[62],"F(ab')2":[64,200],"fragments":[65,89,114,210],"MAb.":[70],"were":[73,108],"operated":[74],"on":[75],"1":[76],"to":[77],"3":[78],"days":[79],"injection,":[82],"surgeon":[85],"removed":[86],"large":[87,112,208],"tumor":[88,92,113,159,209,217],"and/or":[90],"small":[91,158,216],"nodules":[93,160,218],"and,":[94],"some":[96],"patients,":[97],"collected":[98],"residual":[100],"perfusion":[101],"fluid":[102],"from":[103],"which":[104],"malignant":[105,171,220],"cell":[106,172,221],"clusters":[107,173],"isolated.":[109],"Uptake":[110,156],"by":[111,157],"at":[115,164,182],"24":[116,183],"h":[117,166,184],"low:":[119],"0.0031":[120],"+/-":[121,133,148,154,162],"0.0032%":[122],"injected":[123],"dose":[124],"per":[125],"gram":[126],"(%ID/g)":[127],"0.0024":[132],"0.0022%ID/g":[134],"IV.":[137],"It":[138,223],"moderately":[140],"higher":[141],"than":[142],"that":[143,227],"(0.0014":[147],"0.0006%ID/g)":[149],"(0.0015":[153],"0.0007%ID/g).":[155],"(0.1302":[161],"0.0802%ID/g":[163],"72":[165],"I)":[169],"(median:":[174],"0.3322,":[175],"a":[177],"maximum":[178],"value":[179],"4.1614%ID/g":[181],"IV)":[187],"markedly":[189],"higher.":[190],"Tumor-to-normal":[191],"tissue":[192],"ratios":[193],"[intact":[198],"or":[199],"fragments]":[201],"ranged":[202],"between":[203],"0.1":[204],"8.5":[206],"2":[212],"8,700":[214],"clusters.":[222],"would":[224],"thus":[225],"appear":[226],"RIT":[228],"is":[229],"feasible":[230],"if":[231],"an":[232],"appropriate":[233],"radionuclide":[234],"can":[235],"be":[236],"selected":[237],"labeling.":[240]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}