{"id":"https://openalex.org/W167452604","doi":null,"title":"Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs.","display_name":"Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs.","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W167452604","mag":"167452604","pmid":"https://pubmed.ncbi.nlm.nih.gov/8406593","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421911"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1421911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421911","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421911","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005195530","display_name":"Damien Schreuer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Schreuer","raw_affiliation_strings":["Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056231558","display_name":"Bruce Hammerberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Hammerberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6727,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.6924722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"4","first_page":"658","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brugia-pahangi","display_name":"Brugia pahangi","score":1.0},{"id":"https://openalex.org/keywords/lymphatic-filariasis","display_name":"lymphatic filariasis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.628000020980835},{"id":"https://openalex.org/keywords/lymph-node-cell-proliferation","display_name":"lymph node cell proliferation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/limb-edema","display_name":"limb edema","score":0.7570000290870667},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.44200000166893005},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2776573122","wikidata":"https://www.wikidata.org/wiki/Q4978677","display_name":"Brugia pahangi","level":3,"score":0.7739052772521973},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.7444127202033997},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6886563301086426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6497631072998047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.573533296585083},{"id":"https://openalex.org/C2780050583","wikidata":"https://www.wikidata.org/wiki/Q2702796","display_name":"Phytohaemagglutinin","level":3,"score":0.5600677132606506},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.508815348148346},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.47254085540771484},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.42190489172935486},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.100107342004776}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000909","descriptor_name":"Antibodies, Helminth","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017179","descriptor_name":"Brugia pahangi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1421911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421911","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:8406593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8406593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:167452604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8406593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1421911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421911","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1187207","https://openalex.org/W17587409","https://openalex.org/W1482502955","https://openalex.org/W1492381049","https://openalex.org/W1515615230","https://openalex.org/W1516433373","https://openalex.org/W1541948797","https://openalex.org/W1546427306","https://openalex.org/W1551770882","https://openalex.org/W1556865496","https://openalex.org/W1567096698","https://openalex.org/W1671573676","https://openalex.org/W1673901538","https://openalex.org/W1895257439","https://openalex.org/W1903165307","https://openalex.org/W1965366343","https://openalex.org/W2011503108","https://openalex.org/W2014655359","https://openalex.org/W2024291148","https://openalex.org/W2033447756","https://openalex.org/W2074611876","https://openalex.org/W2075886517","https://openalex.org/W2083805299","https://openalex.org/W2111840434","https://openalex.org/W2116217588","https://openalex.org/W2132259255","https://openalex.org/W2293041249","https://openalex.org/W2333413219","https://openalex.org/W2395690934"],"related_works":["https://openalex.org/W1673901538","https://openalex.org/W2395690934","https://openalex.org/W2011503108","https://openalex.org/W2131431148","https://openalex.org/W2040062725","https://openalex.org/W2407464523","https://openalex.org/W2288746956","https://openalex.org/W2328414457","https://openalex.org/W2789104470","https://openalex.org/W7099280058"],"abstract_inverted_index":{"Recently,":[0],"it":[1],"has":[2],"become":[3],"possible":[4],"to":[5,31,118,144,152,173,248],"obtain":[6],"as":[7,252],"predicted":[8],"disease":[9,78,263],"manifestation":[10],"in":[11,38,43,120,140,201,254,262],"selectively":[12,61],"bred":[13],"dogs":[14,59,92,218],"infected":[15,122,191,207],"with":[16,35,236],"the":[17,44,48,65,72,104,121,128,141,145,174,183,194,245,274,279],"naturally":[18],"occurring":[19,42],"lymphatic":[20,249],"nematode,":[21],"Brugia":[22],"pahangi.":[23],"In":[24,108,134],"this":[25,255],"study,":[26,256],"an":[27],"attempt":[28],"was":[29,81,125,137,179,211,223],"made":[30],"correlate":[32,235],"limb":[33],"oedema":[34],"dynamic":[36],"changes":[37,232],"immune":[39,246,276],"cell":[40],"responses":[41],"lymph":[45,187,208],"node":[46,86,123,156,188,209],"at":[47,98,219,226],"site":[49],"of":[50,54,58,67,74,76,82,90,106,110,115,130,132,163,166,186,196,241,282],"infection":[51],"during":[52],"onset":[53,105,131],"patency.":[55,107,133],"Three":[56],"litters":[57],"were":[60],"bred;":[62],"one":[63,70,80],"for":[64,71],"expression":[66,75,195],"clinical":[68,77,197,237,280],"disease,":[69],"lack":[73,240],"and":[79,193,265,278],"non-specific":[83],"phenotype.":[84],"Lymph":[85],"cells":[87,124,157,189,210],"from":[88,190],"10":[89],"11":[91,111],"showed":[93],"a":[94,113],"parasite-specific":[95,203,275],"proliferative":[96,116,142,150,184],"response":[97,117,143,151,185,247,277],"4-6":[99],"weeks":[100,221,228],"post-infection":[101],"(p.i.),":[102],"before":[103],"six":[109],"dogs,":[112],"loss":[114],"BpA":[119,153],"detected":[126],"around":[127],"time":[129],"contrast,":[135],"there":[136,178],"no":[138,180],"reduction":[139],"mitogen":[146],"phytohaemagglutinin":[147],"(PHA).":[148],"The":[149],"by":[154,161,206,216],"unresponsive":[155],"could":[158],"be":[159],"restored":[160],"addition":[162],"substimulatory":[164],"amounts":[165],"murine":[167],"or":[168],"human":[169],"recombinant":[170],"interleukin-2":[171],"(IL-2)":[172],"culture":[175],"medium.":[176],"However,":[177],"correlation":[181,242],"between":[182],"limbs":[192],"disease.":[198,238],"Similarly,":[199],"when":[200],"vitro":[202],"antibody":[204,213],"production":[205,214],"examined,":[212],"manifested":[215],"all":[217],"5":[220],"p.i.":[222],"markedly":[224],"changed":[225],"8":[227],"p.i.,":[229],"but":[230],"these":[231],"did":[233],"not":[234,258],"This":[239],"indicates":[243],"that":[244,266],"filarial":[250],"infection,":[251],"measured":[253],"does":[257],"necessarily":[259],"result":[260],"directly":[261],"manifestation,":[264],"other":[267],"genetically":[268],"determined":[269],"factors":[270],"may":[271],"influence":[272],"both":[273],"outcome":[281],"infection.":[283]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}