{"id":"https://openalex.org/W1673942909","doi":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","title":"Minimizing Synaptic Depression by Control of Release Probability","display_name":"Minimizing Synaptic Depression by Control of Release Probability","publication_year":2001,"publication_date":"2001-03-15","ids":{"openalex":"https://openalex.org/W1673942909","doi":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","mag":"1673942909","pmid":"https://pubmed.ncbi.nlm.nih.gov/11245670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6762601"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.21-06-01857.2001","doi":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/6/1857.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jneurosci.org/content/jneuro/21/6/1857.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002589454","display_name":"Stephan D. Brenowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Brenowitz","raw_affiliation_strings":["Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, and","Oregon Hearing Research Center and Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, and","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Oregon Hearing Research Center and Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027038334","display_name":"Laurence O. Trussell","orcid":"https://orcid.org/0000-0003-1171-2356","observed_orcids":["https://orcid.org/0000-0003-1171-2356"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence O. Trussell","raw_affiliation_strings":["Oregon Hearing Research Center and Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Hearing Research Center and Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4348,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.93260904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"6","first_page":"1857","last_page":"1867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-depression","display_name":"synaptic depression","score":0.9869999885559082},{"id":"https://openalex.org/keywords/release-probability","display_name":"release probability","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/presynaptic-modulation","display_name":"presynaptic modulation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ampa-receptor-desensitization","display_name":"AMPA receptor desensitization","score":0.9549999833106995},{"id":"https://openalex.org/keywords/postsynaptic-depression","display_name":"postsynaptic depression","score":0.921999990940094},{"id":"https://openalex.org/keywords/auditory-nerve","display_name":"auditory nerve","score":0.5139999985694885},{"id":"https://openalex.org/keywords/nucleus-magnocellularis","display_name":"nucleus magnocellularis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/epsc","display_name":"EPSC","score":0.39100000262260437},{"id":"https://openalex.org/keywords/baclofen","display_name":"baclofen","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aniracetam","display_name":"aniracetam","score":0.9959999918937683},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7131443023681641},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.622790515422821},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5790542960166931},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.5583994388580322},{"id":"https://openalex.org/C125667969","wikidata":"https://www.wikidata.org/wiki/Q7662036","display_name":"Synaptic fatigue","level":4,"score":0.5121943354606628},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4890538156032562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4354349374771118},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.42287373542785645},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.4156917631626129},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4041004478931427},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.3413843512535095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31168317794799805},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2595462203025818},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21315345168113708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09312555193901062}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001306","descriptor_name":"Auditory Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001306","descriptor_name":"Auditory Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018684","descriptor_name":"Glycine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.21-06-01857.2001","doi":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/6/1857.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6762601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6762601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:11245670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11245670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.495.779","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.495.779","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cns.nyu.edu/events/earclub/artfiles/Brenowitz2001.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.21-06-01857.2001","doi":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-06-01857.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/6/1857.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1418006018","display_name":"Regulation of synaptic amino acid receptors","funder_award_id":"R01NS028901","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2037627799","display_name":null,"funder_award_id":"GM 07507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5249168341","display_name":"Regulation of synaptic amino acid receptors","funder_award_id":"R37NS028901","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6618630211","display_name":"Neuroscience Training Program","funder_award_id":"T32GM007507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7033105698","display_name":null,"funder_award_id":"NS28901","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1673942909.pdf","grobid_xml":"https://content.openalex.org/works/W1673942909.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W22443812","https://openalex.org/W150198096","https://openalex.org/W1571745125","https://openalex.org/W1572375141","https://openalex.org/W1601000163","https://openalex.org/W1608408896","https://openalex.org/W1861463350","https://openalex.org/W1951802359","https://openalex.org/W1967599965","https://openalex.org/W1971656169","https://openalex.org/W1986201521","https://openalex.org/W1989795714","https://openalex.org/W1991749817","https://openalex.org/W2001520037","https://openalex.org/W2001860569","https://openalex.org/W2009011152","https://openalex.org/W2019016101","https://openalex.org/W2019560601","https://openalex.org/W2020098765","https://openalex.org/W2022104262","https://openalex.org/W2022995207","https://openalex.org/W2031543773","https://openalex.org/W2031811225","https://openalex.org/W2036445073","https://openalex.org/W2038359286","https://openalex.org/W2050179527","https://openalex.org/W2055334158","https://openalex.org/W2059381606","https://openalex.org/W2064748241","https://openalex.org/W2068961612","https://openalex.org/W2074258705","https://openalex.org/W2074361963","https://openalex.org/W2076883859","https://openalex.org/W2078039225","https://openalex.org/W2080809219","https://openalex.org/W2083045813","https://openalex.org/W2087758815","https://openalex.org/W2088880312","https://openalex.org/W2090662268","https://openalex.org/W2105848238","https://openalex.org/W2109205784","https://openalex.org/W2112927743","https://openalex.org/W2116573581","https://openalex.org/W2124985215","https://openalex.org/W2135662935","https://openalex.org/W2142005996","https://openalex.org/W2153499119","https://openalex.org/W2156862443","https://openalex.org/W2162668311","https://openalex.org/W2167725643","https://openalex.org/W2171021618","https://openalex.org/W2415887941","https://openalex.org/W2467694862","https://openalex.org/W3021526609","https://openalex.org/W4229831262","https://openalex.org/W6818773663"],"related_works":["https://openalex.org/W2167812349","https://openalex.org/W1547462259","https://openalex.org/W2109205784","https://openalex.org/W2050179527","https://openalex.org/W1959457034","https://openalex.org/W2116573581","https://openalex.org/W2044797107","https://openalex.org/W2079648141","https://openalex.org/W3168667872","https://openalex.org/W2153963764"],"abstract_inverted_index":{"Transmission":[0],"at":[1,38,253],"the":[2,11,16,132,168,172,209,237,249],"end-bulb":[3],"synapse":[4,40],"formed":[5],"by":[6,22,60,82,208,220,233],"auditory":[7,255],"nerve":[8],"terminals":[9],"onto":[10],"soma":[12],"of":[13,32,87,105,113,125,134,145,150,165,171,180,182,203,214,223,239,251],"neurons":[14],"in":[15],"avian":[17],"nucleus":[18],"magnocellularis":[19],"is":[20],"characterized":[21],"high":[23],"transmitter":[24,84],"release":[25,69,107,155,204],"probability":[26,70,156],"and":[27,41,243],"strong":[28],"synaptic":[29,44,52,135,245],"depression.":[30],"Activation":[31],"presynaptic":[33,88,231],"GABA(B)":[34,234],"receptors":[35,127,235],"minimizes":[36],"depression":[37,115,136],"this":[39,55,148],"significantly":[42],"enhances":[43],"strength":[45],"during":[46,100,137,143,193],"high-frequency":[47,101],"activity.":[48],"Here":[49],"we":[50],"investigate":[51],"mechanisms":[53],"underlying":[54],"phenomenon.":[56],"EPSC":[57,93,173,191],"amplitudes":[58,94,192,225],"evoked":[59],"200":[61],"Hz":[62],"trains":[63,144,194],"increased":[64],"more":[65],"than":[66],"twofold":[67],"when":[68,154],"was":[71,79,116,152,157,174,186,218],"reduced":[72,187],"with":[73,159,188],"Cd(2+)":[74],"or":[75,161],"baclofen.":[76],"This":[77],"effect":[78,149,164],"not":[80],"exhibited":[81],"a":[83,96,123,177,200],"depletion":[85,210],"model":[86],"depression,":[89],"which":[90],"predicts":[91],"that":[92,128,140],"reach":[95],"common":[97],"steady-state":[98,190],"amplitude":[99],"trains,":[102,138],"despite":[103],"alterations":[104],"initial":[106],"probability.":[108],"However,":[109,147],"an":[110,254],"additional":[111],"source":[112],"postsynaptic":[114,178],"sufficient":[117],"to":[118,197],"explain":[119],"our":[120],"findings.":[121],"Aniracetam,":[122],"modulator":[124],"AMPA":[126,215,240],"reduces":[129],"desensitization,":[130],"decreased":[131],"amount":[133],"indicating":[139],"desensitization":[141,185,217,242],"occurred":[142],"stimuli.":[146],"aniracetam":[151,166],"absent":[153],"lowered":[158],"baclofen":[160],"Cd(2+).":[162],"No":[163],"on":[167],"NMDA":[169],"component":[170],"seen,":[175],"confirming":[176],"site":[179],"action":[181],"aniracetam.":[183],"When":[184],"aniracetam,":[189],"were":[195],"found":[196],"converge":[198],"over":[199],"wide":[201],"range":[202],"probabilities,":[205],"as":[206],"predicted":[207],"model.":[211],"Additional":[212],"evidence":[213],"receptor":[216,241],"provided":[219],"direct":[221],"measurement":[222],"quantal":[224],"immediately":[226],"after":[227],"stimulus":[228],"trains.":[229],"Thus,":[230],"modulation":[232],"regulates":[236],"extent":[238],"controls":[244],"strength,":[246],"thereby":[247],"modulating":[248],"flow":[250],"information":[252],"synapse.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}