{"id":"https://openalex.org/W167354888","doi":null,"title":"Effect of food and gastric acidity on absorption of orally administered ketoconazole.","display_name":"Effect of food and gastric acidity on absorption of orally administered ketoconazole.","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W167354888","mag":"167354888","pmid":"https://pubmed.ncbi.nlm.nih.gov/3356120"},"language":"en","primary_location":{"id":"pmid:3356120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3356120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacy","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053104055","display_name":"P. Lelawongs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Lelawongs","raw_affiliation_strings":["College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091669128","display_name":"Joseph A. Barone","orcid":"https://orcid.org/0000-0003-4225-3383","observed_orcids":["https://orcid.org/0000-0003-4225-3383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Barone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041659249","display_name":"John L. Colaizzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Colaizzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027800920","display_name":"Alice T. M. Hsuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A T Hsuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042368020","display_name":"Witold Mechlinski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Mechlinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030079102","display_name":"R. Legendre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Legendre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065185341","display_name":"Joseph A. Guarnieri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Guarnieri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.976,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.95486783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"228","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketoconazole","display_name":"ketoconazole","score":1.0},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.5759999752044678},{"id":"https://openalex.org/keywords/gastric-acidity","display_name":"gastric acidity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oral-drug-absorption","display_name":"oral drug absorption","score":0.6589999794960022},{"id":"https://openalex.org/keywords/high-fat-meal","display_name":"high-fat meal","score":0.9610000252723694},{"id":"https://openalex.org/keywords/high-carbohydrate-meal","display_name":"high-carbohydrate meal","score":0.9049999713897705},{"id":"https://openalex.org/keywords/achlorhydria","display_name":"achlorhydria","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/plasma-concentration-time-curve","display_name":"plasma concentration-time curve","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2781064554","wikidata":"https://www.wikidata.org/wiki/Q407883","display_name":"Ketoconazole","level":3,"score":0.9532836675643921},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7576261162757874},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7090383768081665},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6346370577812195},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5955244898796082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5418627262115479},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.4725622534751892},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.45137327909469604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25194793939590454},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3356120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3356120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacy","raw_type":"Clinical Trial"},{"id":"mag:167354888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3356120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000532092","https://openalex.org/W2146513536","https://openalex.org/W1983454004","https://openalex.org/W2007957750","https://openalex.org/W2065275325","https://openalex.org/W2081517724","https://openalex.org/W2109128426","https://openalex.org/W2046222880","https://openalex.org/W1979794877","https://openalex.org/W2439619728"],"abstract_inverted_index":{"Effects":[0],"of":[1,9,142],"food":[2],"and":[3,83,86,115,152,166,193,210,219,232],"gastric":[4],"acidity":[5],"on":[6],"the":[7,134,156,161,172],"bioavailability":[8],"ketoconazole":[10,32,40,49,58,72,88,164,175],"tablets":[11],"were":[12,103,138],"investigated":[13],"in":[14,75,96,109,217],"12":[15],"volunteers":[16,25],"using":[17],"a":[18,37,44,53,76,97,184,203],"six-treatment,":[19],"randomized,":[20],"Latin-square":[21],"crossover":[22],"design.":[23],"All":[24],"received":[26],"all":[27],"treatments,":[28],"as":[29,69],"follows:":[30],"(A)":[31],"200":[33,41,50,59,73,89],"mg":[34,42,51,60,68,74,90],"administered":[35,91],"after":[36,61,122],"fast;":[38],"(B)":[39],"with":[43,52,63,81,92,179,190,197,207,223,235],"standardized":[45,54],"high-fat":[46],"meal;":[47,56],"(C)":[48],"high-carbohydrate":[55],"(D)":[57],"pretreatment":[62],"glutamic":[64,93],"acid":[65,94],"hydrochloride":[66,95],"680":[67],"capsules;":[70],"(E)":[71],"simulated":[77,98],"achlorhydric":[78,99],"state":[79],"induced":[80],"cimetidine":[82],"sodium":[84],"bicarbonate;":[85],"(F)":[87],"state.":[100],"Ketoconazole":[101],"concentrations":[102],"measured":[104],"by":[105,145],"high-performance":[106],"liquid":[107],"chromatography":[108],"plasma":[110,163,174],"samples":[111],"drawn":[112],"immediately":[113],"before":[114],"at":[116],"various":[117],"times":[118,157],"over":[119],"24":[120],"hours":[121],"drug":[123],"administration.":[124],"Bioavailability":[125],"variables,":[126],"including":[127],"natural":[128],"logarithm":[129],"transformation":[130],"for":[131],"area":[132],"under":[133],"concentration-time":[135],"curve":[136],"(AUC),":[137],"subjected":[139],"to":[140,159],"analysis":[141],"variance":[143],"followed":[144],"Duncan's":[146],"Multiple":[147],"Range":[148],"testing.":[149],"Treatments":[150],"B":[151,192],"C":[153,168],"significantly":[154,170,228],"prolonged":[155],"required":[158],"achieve":[160],"peak":[162,173],"concentration,":[165],"treatment":[167,180,191,198,208,211,224,236],"also":[169],"reduced":[171],"concentration":[176],"(Cmax)":[177],"compared":[178,206,222,234],"A.":[181,225],"There":[182],"was":[183],"trend":[185],"toward":[186],"increased":[187,229],"AUC":[188,195,220,230],"values":[189,196,221,231],"decreased":[194],"C.":[199],"Treatment":[200,226],"D":[201],"produced":[202,213],"higher":[204],"Cmax":[205,218,233],"A,":[209],"E":[212],"large,":[214],"significant":[215],"reductions":[216],"F":[227],"E.(ABSTRACT":[237],"TRUNCATED":[238],"AT":[239],"250":[240],"WORDS)":[241]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
