{"id":"https://openalex.org/W1673347367","doi":"https://doi.org/10.1111/j.1742-4658.2005.04909.x","title":"Crystal structure of the soluble form of the redox\u2010regulated chloride ion channel protein CLIC4","display_name":"Crystal structure of the soluble form of the redox\u2010regulated chloride ion channel protein CLIC4","publication_year":2005,"publication_date":"2005-09-16","ids":{"openalex":"https://openalex.org/W1673347367","doi":"https://doi.org/10.1111/j.1742-4658.2005.04909.x","mag":"1673347367","pmid":"https://pubmed.ncbi.nlm.nih.gov/16176272"},"language":"en","primary_location":{"id":"doi:10.1111/j.1742-4658.2005.04909.x","doi":"https://doi.org/10.1111/j.1742-4658.2005.04909.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2005.04909.x","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071832564","display_name":"Dene R. Littler","orcid":"https://orcid.org/0000-0001-5904-1905","observed_orcids":["https://orcid.org/0000-0001-5904-1905"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dene R. Littler","raw_affiliation_strings":["School of Physics, University of New South Wales, Sydney, Australia","Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001378661","display_name":"Nagi N. Assaad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nagi N. Assaad","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","School of Physics, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]},{"raw_affiliation_string":"School of Physics, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032871211","display_name":"S.J. Harrop","orcid":"https://orcid.org/0000-0002-1700-3369","observed_orcids":["https://orcid.org/0000-0002-1700-3369"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen J. Harrop","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","School of Physics, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]},{"raw_affiliation_string":"School of Physics, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086272410","display_name":"Louise Jennifer Brown","orcid":"https://orcid.org/0000-0001-8592-2431","observed_orcids":["https://orcid.org/0000-0001-8592-2431"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Louise J. Brown","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, Australia","School of Physics, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]},{"raw_affiliation_string":"Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, Australia","institution_ids":["https://openalex.org/I99043593"]},{"raw_affiliation_string":"School of Physics, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044450748","display_name":"Greg J. Pankhurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Greg J. Pankhurst","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paolo Luciani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Luciani","raw_affiliation_strings":["Department of Cellular and Developmental Biology, University of Rome \u2018La Sapienza\u2019, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Developmental Biology, University of Rome \u2018La Sapienza\u2019, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111459936","display_name":"Marie\u2010Isabel Aguilar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marie\u2010Isabel Aguilar","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001450159","display_name":"Michele Mazzanti","orcid":"https://orcid.org/0000-0002-1819-3811","observed_orcids":["https://orcid.org/0000-0002-1819-3811"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Mazzanti","raw_affiliation_strings":["Department of Cellular and Developmental Biology, University of Rome \u2018La Sapienza\u2019, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Developmental Biology, University of Rome \u2018La Sapienza\u2019, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032831725","display_name":"Mark A. Berryman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Berryman","raw_affiliation_strings":["Department of Biomedical Sciences, Molecular and Cellular Biology Program, Ohio University College of Osteopathic Medicine, Athens, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Molecular and Cellular Biology Program, Ohio University College of Osteopathic Medicine, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070606019","display_name":"Samuel N. Breit","orcid":"https://orcid.org/0000-0002-9021-9879","observed_orcids":["https://orcid.org/0000-0002-9021-9879"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Samuel N. Breit","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045158875","display_name":"Paul M. G. Curmi","orcid":"https://orcid.org/0000-0001-5762-7638","observed_orcids":["https://orcid.org/0000-0001-5762-7638"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul M. G. Curmi","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","School of Physics, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"]},{"raw_affiliation_string":"School of Physics, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.9823,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.84810004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"272","issue":"19","first_page":"4996","last_page":"5007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.1875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clic4","display_name":"CLIC4","score":1.0},{"id":"https://openalex.org/keywords/chloride-channels","display_name":"chloride channels","score":0.7239999771118164},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.652999997138977},{"id":"https://openalex.org/keywords/membrane-binding","display_name":"membrane binding","score":0.49900001287460327},{"id":"https://openalex.org/keywords/chloride-efflux","display_name":"chloride efflux","score":0.6959999799728394},{"id":"https://openalex.org/keywords/ion-channel-conductance","display_name":"ion channel conductance","score":0.781000018119812},{"id":"https://openalex.org/keywords/clic1","display_name":"CLIC1","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.654236376285553},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5921487212181091},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5230996608734131},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.501873254776001},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4625287652015686},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.459074467420578},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.4580686390399933},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.41484329104423523},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.40693289041519165},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3360480070114136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3181602358818054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19784796237945557},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.14700758457183838},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08346784114837646},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1742-4658.2005.04909.x","doi":"https://doi.org/10.1111/j.1742-4658.2005.04909.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2005.04909.x","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:16176272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16176272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1543593287","https://openalex.org/W1574082488","https://openalex.org/W1775225822","https://openalex.org/W1905002967","https://openalex.org/W1976093993","https://openalex.org/W1976690731","https://openalex.org/W1982705969","https://openalex.org/W1986191025","https://openalex.org/W1989826242","https://openalex.org/W1992934067","https://openalex.org/W2000542458","https://openalex.org/W2001641653","https://openalex.org/W2004937148","https://openalex.org/W2013083986","https://openalex.org/W2037809197","https://openalex.org/W2038840577","https://openalex.org/W2042293477","https://openalex.org/W2061377366","https://openalex.org/W2064837843","https://openalex.org/W2065569894","https://openalex.org/W2069166464","https://openalex.org/W2073821224","https://openalex.org/W2080476827","https://openalex.org/W2084575458","https://openalex.org/W2086466051","https://openalex.org/W2107098864","https://openalex.org/W2122191456","https://openalex.org/W2126645075","https://openalex.org/W2132863919","https://openalex.org/W2146396831","https://openalex.org/W2149166640","https://openalex.org/W2156891333","https://openalex.org/W2162838711","https://openalex.org/W2164797647","https://openalex.org/W2166636567","https://openalex.org/W2169240396"],"related_works":["https://openalex.org/W2126645075","https://openalex.org/W2162838711","https://openalex.org/W2031092352","https://openalex.org/W2036534542","https://openalex.org/W1985596675","https://openalex.org/W2560063172","https://openalex.org/W7098397728","https://openalex.org/W2008239718","https://openalex.org/W1970955906","https://openalex.org/W7097730372"],"abstract_inverted_index":{"The":[0,27,77],"structure":[1],"of":[2,6,10,48,96,132,141,154,174],"CLIC4,":[3],"a":[4,69,112,130,155,167],"member":[5],"the":[7,40,46,58,85,89,97,152,172],"CLIC":[8],"family":[9],"putative":[11],"intracellular":[12],"chloride":[13,113],"ion":[14,124,169],"channel":[15,125,170],"proteins,":[16],"has":[17,63],"been":[18,65],"determined":[19],"at":[20],"1.8":[21],"Angstroms":[22],"resolution":[23],"by":[24,139],"X-ray":[25],"crystallography.":[26],"protein":[28],"is":[29,33,103,137],"monomeric":[30],"and":[31,50,121],"it":[32],"structurally":[34],"similar":[35],"to":[36,39,54,67,93,105,107,162,165],"CLIC1,":[37],"belonging":[38],"GST":[41],"fold":[42],"class.":[43],"Differences":[44],"between":[45],"structures":[47],"CLIC1":[49,74,90],"CLIC4":[51,102,142,160],"are":[52],"localized":[53],"helix":[55],"2":[56],"in":[57,73,80,126,151,171],"glutaredoxin-like":[59],"N-terminal":[60],"domain,":[61],"which":[62],"previously":[64],"shown":[66,104],"undergo":[68],"dramatic":[70],"structural":[71,78],"change":[72],"upon":[75],"oxidation.":[76],"differences":[79],"this":[81],"region":[82],"correlate":[83],"with":[84,118,129],"sequence":[86,91],"differences,":[87],"where":[88],"appears":[92,161],"be":[94,163],"atypical":[95],"family.":[98],"Purified,":[99],"recombinant,":[100],"wild-type":[101],"bind":[106],"artificial":[108,119,127],"lipid":[109],"bilayers,":[110],"induce":[111],"efflux":[114],"current":[115],"when":[116],"associated":[117],"liposomes":[120],"produce":[122],"an":[123],"bilayers":[128],"conductance":[131],"30":[133],"pS.":[134],"Membrane":[135],"binding":[136],"enhanced":[138],"oxidation":[140],"while":[143],"no":[144],"channels":[145],"were":[146],"observed":[147],"via":[148],"tip-dip":[149],"electrophysiology":[150],"presence":[153],"reducing":[156],"agent.":[157],"Thus,":[158],"recombinant":[159],"able":[164],"form":[166],"redox-regulated":[168],"absence":[173],"any":[175],"partner":[176],"proteins.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}