{"id":"https://openalex.org/W1673158685","doi":null,"title":"Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder.","display_name":"Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W1673158685","mag":"1673158685","pmid":"https://pubmed.ncbi.nlm.nih.gov/2274626"},"language":"en","primary_location":{"id":"pmid:2274626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2274626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology bulletin","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110419096","display_name":"Guy Chouinard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G Chouinard","raw_affiliation_strings":["McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014105109","display_name":"Wayne K. Goodman","orcid":"https://orcid.org/0000-0001-6717-082X","observed_orcids":["https://orcid.org/0000-0001-6717-082X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Goodman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064151665","display_name":"John H. Greist","orcid":"https://orcid.org/0000-0002-4712-6132","observed_orcids":["https://orcid.org/0000-0002-4712-6132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Greist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076670522","display_name":"Michael A. Jenike","orcid":"https://orcid.org/0000-0002-3728-089X","observed_orcids":["https://orcid.org/0000-0002-3728-089X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jenike","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101661632","display_name":"S. Rasmussen","orcid":"https://orcid.org/0000-0001-5434-0519","observed_orcids":["https://orcid.org/0000-0001-5434-0519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rasmussen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081984563","display_name":"Elizabeth Hackett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Hackett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102721357","display_name":"Michael Gaffney","orcid":"https://orcid.org/0000-0002-7552-6942","observed_orcids":["https://orcid.org/0000-0002-7552-6942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gaffney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012019600","display_name":"Peter A. Bick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Bick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.4479,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.99118865,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"3","first_page":"279","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.972000002861023},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/y-bocs","display_name":"Yale-Brown Obsessive Compulsive Scale","score":0.9670000076293945},{"id":"https://openalex.org/keywords/maudsley-obsessive-compulsive-inventory","display_name":"Maudsley Obsessive-Compulsive Inventory","score":0.871999979019165},{"id":"https://openalex.org/keywords/clinical-global-impression-scale","display_name":"Clinical Global Impression Scale","score":0.6259999871253967},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.9305515289306641},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.9015557765960693},{"id":"https://openalex.org/C3017582312","wikidata":"https://www.wikidata.org/wiki/Q178190","display_name":"Obsessive compulsive","level":2,"score":0.6075671911239624},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.5595502257347107},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.49448633193969727},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4441969692707062},{"id":"https://openalex.org/C202061045","wikidata":"https://www.wikidata.org/wiki/Q7200267","display_name":"Placebo-controlled study","level":5,"score":0.4251604676246643},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.42056381702423096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4070125222206116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3950997591018677},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3757874369621277},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.12202125787734985},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.10579290986061096},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015057","descriptor_name":"1-Naphthylamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015057","descriptor_name":"1-Naphthylamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020280","descriptor_name":"Sertraline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2274626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2274626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology bulletin","raw_type":"Clinical Trial"},{"id":"mag:1673158685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2274626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996929172","https://openalex.org/W2027068711","https://openalex.org/W1975902708","https://openalex.org/W2063793759","https://openalex.org/W2057027260","https://openalex.org/W2146268699","https://openalex.org/W2767363871","https://openalex.org/W2160214171","https://openalex.org/W158570133","https://openalex.org/W2007977708"],"abstract_inverted_index":{"Eighty-seven":[0],"patients":[1,34,77],"with":[2,132,158],"a":[3,15,24,30,45,61,151],"DSM-III":[4],"diagnosis":[5],"of":[6,19,22,63,72,123,135,155],"obsessive-compulsive":[7],"disorder":[8],"(OCD)":[9],"without":[10],"depression":[11],"were":[12,35,78,127],"entered":[13],"into":[14],"double-blind,":[16],"placebo-controlled":[17],"study":[18],"the":[20,51,70,73,83,91,116,136,140,144],"efficacy":[21],"sertraline,":[23],"new":[25],"serotonin":[26],"uptake":[27],"inhibitor.":[28],"After":[29,44],"1-week":[31],"washout":[32],"period,":[33],"randomly":[36],"assigned":[37],"to":[38,60],"receive":[39],"either":[40],"placebo":[41],"or":[42],"sertraline.":[43],"2-week":[46],"titration":[47],"period":[48],"in":[49,121],"which":[50],"once-daily":[52],"sertraline":[53,156],"dose":[54],"was":[55,67,88],"increased":[56],"from":[57],"50":[58],"mg/day":[59],"maximum":[62],"200":[64],"mg/day,":[65],"dosage":[66],"maintained":[68],"until":[69],"end":[71],"eighth":[74],"week,":[75],"then":[76],"titrated":[79],"off":[80],"medication":[81],"over":[82],"next":[84],"2":[85],"weeks.":[86],"Efficacy":[87],"measured":[89],"by":[90],"Yale-Brown":[92],"Obsessive-Compulsive":[93,98],"Scale":[94],"(Y-BOCS),":[95],"NIMH":[96,141],"General":[97],"Scale,":[99],"Maudsley":[100],"Obsessive":[101],"Compulsive":[102],"(MOC)":[103],"Inventory,":[104],"and":[105,111,143,147],"Clinical":[106],"Global":[107],"Impressions":[108],"(CGI)":[109],"Severity":[110],"Improvement":[112],"scales.":[113],"Results":[114,134],"on":[115],"MOC":[117],"Inventory":[118],"showed":[119],"trends":[120],"favor":[122],"active":[124],"drug":[125],"that":[126],"not":[128],"statistically":[129,152],"significant":[130,153],"compared":[131,157],"placebo.":[133,159],"Y-BOCS":[137],"total":[138],"score,":[139,142],"global":[145],"severity":[146],"improvement":[148],"scores":[149],"demonstrated":[150],"superiority":[154]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
