{"id":"https://openalex.org/W16728992","doi":"https://doi.org/10.1007/978-1-4615-8186-4_9","title":"Liver Support Through Hepatic Tissue Engineering","display_name":"Liver Support Through Hepatic Tissue Engineering","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W16728992","doi":"https://doi.org/10.1007/978-1-4615-8186-4_9","mag":"16728992"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-8186-4_9","doi":"https://doi.org/10.1007/978-1-4615-8186-4_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-8186-4_9","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4212839539","display_name":"Tissue Engineering"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075867487","display_name":"Mehmet Toner","orcid":"https://orcid.org/0000-0002-3647-3665","observed_orcids":["https://orcid.org/0000-0002-3647-3665"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Toner","raw_affiliation_strings":["Surgical Services, Massachusetts General Hospital, Shriners Burns Institute, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Services, Massachusetts General Hospital, Shriners Burns Institute, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008085561","display_name":"Ronald Gary Tompkins","orcid":"https://orcid.org/0000-0002-0859-526X","observed_orcids":["https://orcid.org/0000-0002-0859-526X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Tompkins","raw_affiliation_strings":["Surgical Services, Massachusetts General Hospital, Shriners Burns Institute, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Services, Massachusetts General Hospital, Shriners Burns Institute, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055658784","display_name":"Martin L. Yarmush","orcid":"https://orcid.org/0000-0003-4986-8444","observed_orcids":["https://orcid.org/0000-0003-4986-8444"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin L. Yarmush","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, USA","Surgical Services, Massachusetts General Hospital, Shriners Burns Institute, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Surgical Services, Massachusetts General Hospital, Shriners Burns Institute, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1349,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.94165471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"92","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-tissue-engineering","display_name":"liver tissue engineering","score":0.9340000152587891},{"id":"https://openalex.org/keywords/liver-support","display_name":"liver support","score":0.7089999914169312},{"id":"https://openalex.org/keywords/bioartificial-liver","display_name":"bioartificial liver","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cell-isolation","display_name":"cell isolation","score":0.4959999918937683},{"id":"https://openalex.org/keywords/cell-culture","display_name":"cell culture","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cell-preservation","display_name":"cell preservation","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.7828372716903687},{"id":"https://openalex.org/C71867830","wikidata":"https://www.wikidata.org/wiki/Q17103308","display_name":"Bioartificial liver device","level":4,"score":0.738490641117096},{"id":"https://openalex.org/C2992176824","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver tissue","level":2,"score":0.5155608654022217},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.46594202518463135},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.42132091522216797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33029401302337646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3188638687133789},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.22727835178375244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20744353532791138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09934389591217041},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06286710500717163},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4615-8186-4_9","doi":"https://doi.org/10.1007/978-1-4615-8186-4_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-8186-4_9","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1433480272","https://openalex.org/W1490154674","https://openalex.org/W1532411911","https://openalex.org/W1966620864","https://openalex.org/W1967009710","https://openalex.org/W1975664930","https://openalex.org/W1988965035","https://openalex.org/W1991822830","https://openalex.org/W2001321884","https://openalex.org/W2017829333","https://openalex.org/W2023465241","https://openalex.org/W2025220089","https://openalex.org/W2039583786","https://openalex.org/W2053419095","https://openalex.org/W2062602912","https://openalex.org/W2062652813","https://openalex.org/W2067188612","https://openalex.org/W2072482644","https://openalex.org/W2072585523","https://openalex.org/W2074739319","https://openalex.org/W2086474578","https://openalex.org/W2086827828","https://openalex.org/W2088377273","https://openalex.org/W2101176389","https://openalex.org/W2107335979","https://openalex.org/W2108467720","https://openalex.org/W2127491255","https://openalex.org/W2157505268","https://openalex.org/W2158993729","https://openalex.org/W2159611123","https://openalex.org/W2170102667","https://openalex.org/W2247420824","https://openalex.org/W2339158886","https://openalex.org/W2407578214","https://openalex.org/W2412435055"],"related_works":["https://openalex.org/W3215530055","https://openalex.org/W2287501499","https://openalex.org/W2435286860","https://openalex.org/W2467205692","https://openalex.org/W3014163099","https://openalex.org/W3147118347","https://openalex.org/W2545305293","https://openalex.org/W2889165517","https://openalex.org/W3171090766","https://openalex.org/W3210241766"],"abstract_inverted_index":{"Tissue":[0],"engineering":[1,37],"is":[2,38],"a":[3,81],"relatively":[4],"new":[5],"field":[6],"which":[7],"brings":[8],"together":[9],"several":[10],"disciplines,":[11],"including":[12],"bioengineering,":[13],"molecular":[14],"and":[15,18,49,65,73,93,98,108,112],"cellular":[16],"biology":[17],"clinical":[19],"medicine,":[20],"with":[21],"the":[22,62,89],"ultimate":[23],"goal":[24],"of":[25,33,35,77,83,91,96,100,106,110],"producing":[26],"tissue":[27,36,114],"or":[28],"organ":[29],"substitutes.":[30],"The":[31],"spectrum":[32],"applications":[34],"indeed":[39],"wide":[40],"from":[41,102],"artificial":[42],"skin":[43],"substitutes":[44],"(Bell":[45],"et":[46,54,69],"al.,":[47,55],"1991)":[48,56],"transplantable":[50],"cell-polymer":[51],"matrices":[52],"(Cima":[53],"to":[57],"bioartificial":[58,63,66],"organs":[59],"such":[60,86],"as":[61,87],"liver":[64],"pancreas":[67],"(Yarmush":[68],"al.,1992a;":[70],"1992b;":[71],"Colton":[72],"Avgoustiniatos,":[74],"1992).":[75],"All":[76],"these":[78],"technologies":[79],"have":[80],"number":[82],"common":[84],"aspects,":[85],"(1)":[88],"identification":[90],"reliable":[92],"efficient":[94],"sources":[95],"cells":[97,101],"isolation":[99],"tissues,":[103],"(2)":[104],"means":[105],"culture":[107],"preservation":[109],"cells,":[111],"(3)":[113],"design.":[115]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}