{"id":"https://openalex.org/W167219936","doi":"https://doi.org/10.1177/0006355x2002039001002017","title":"Human chondrocyte senescence and osteoarthritis","display_name":"Human chondrocyte senescence and osteoarthritis","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W167219936","doi":"https://doi.org/10.1177/0006355x2002039001002017","mag":"167219936","pmid":"https://pubmed.ncbi.nlm.nih.gov/12082277"},"language":"en","primary_location":{"id":"doi:10.1177/0006355x2002039001002017","doi":"https://doi.org/10.1177/0006355x2002039001002017","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0006355x2002039001002017","pdf_url":null,"source":{"id":"https://openalex.org/S48734447","display_name":"Biorheology","issn_l":"0006-355X","issn":["0006-355X","1878-5034"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biorheology: The Official Journal of the International Society of Biorheology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015592017","display_name":"James A. Martin","orcid":"https://orcid.org/0000-0001-5085-0108","observed_orcids":["https://orcid.org/0000-0001-5085-0108"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Martin","raw_affiliation_strings":["University of Iowa Department of Orthopaedic Surgery, Iowa City, IA, USA","University of Iowa Department of Orthopaedic Surgery, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa Department of Orthopaedic Surgery, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"University of Iowa Department of Orthopaedic Surgery, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064323409","display_name":"Joseph A. Buckwalter","orcid":"https://orcid.org/0000-0003-4308-7583","observed_orcids":["https://orcid.org/0000-0003-4308-7583"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Buckwalter","raw_affiliation_strings":["University of Iowa Department of Orthopaedic Surgery, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa Department of Orthopaedic Surgery, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.8012,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.89583671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"39","issue":"1-2","first_page":"145","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrocyte-senescence","display_name":"chondrocyte senescence","score":0.9850000143051147},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9800000190734863},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7870000004768372},{"id":"https://openalex.org/keywords/beta-galactosidase","display_name":"beta-galactosidase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.984000027179718},{"id":"https://openalex.org/keywords/mitotic-rate","display_name":"mitotic activity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.765999972820282},{"id":"https://openalex.org/keywords/chondrocyte-transplantation","display_name":"chondrocyte transplantation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/senescence-markers","display_name":"senescence markers","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.847334623336792},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.825526237487793},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7285071015357971},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7122783064842224},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6681631803512573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5375267267227173},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.48847949504852295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4628775119781494},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4545031487941742},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.43212890625},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.42277273535728455},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3576803505420685},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3284267783164978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31442582607269287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27952760457992554},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22539463639259338},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15156587958335876},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/0006355x2002039001002017","doi":"https://doi.org/10.1177/0006355x2002039001002017","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0006355x2002039001002017","pdf_url":null,"source":{"id":"https://openalex.org/S48734447","display_name":"Biorheology","issn_l":"0006-355X","issn":["0006-355X","1878-5034"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biorheology: The Official Journal of the International Society of Biorheology","raw_type":"journal-article"},{"id":"pmid:12082277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12082277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biorheology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1237294289","https://openalex.org/W1543500873","https://openalex.org/W1751474090","https://openalex.org/W1958939387","https://openalex.org/W1974682017","https://openalex.org/W1979684462","https://openalex.org/W1981072821","https://openalex.org/W1983673827","https://openalex.org/W1991758077","https://openalex.org/W1997007011","https://openalex.org/W1998663807","https://openalex.org/W2000562309","https://openalex.org/W2001630539","https://openalex.org/W2002974844","https://openalex.org/W2004314923","https://openalex.org/W2007421494","https://openalex.org/W2011482325","https://openalex.org/W2016273822","https://openalex.org/W2018543474","https://openalex.org/W2018686812","https://openalex.org/W2024334451","https://openalex.org/W2032253593","https://openalex.org/W2033422116","https://openalex.org/W2035963497","https://openalex.org/W2037647356","https://openalex.org/W2062395030","https://openalex.org/W2078859037","https://openalex.org/W2100189198","https://openalex.org/W2104908670","https://openalex.org/W2107019791","https://openalex.org/W2108482850","https://openalex.org/W2109914347","https://openalex.org/W2112404859","https://openalex.org/W2117494436","https://openalex.org/W2119436088","https://openalex.org/W2120992658","https://openalex.org/W2319757120","https://openalex.org/W2411055527"],"related_works":["https://openalex.org/W2109142422","https://openalex.org/W1907180716","https://openalex.org/W2159315880","https://openalex.org/W7098025827","https://openalex.org/W1482352785","https://openalex.org/W2032691826","https://openalex.org/W285580143","https://openalex.org/W7207652753","https://openalex.org/W7096706102","https://openalex.org/W2001436617"],"abstract_inverted_index":{"Although":[0],"osteoarthritis":[1],"(OA)":[2],"is":[3,26,176],"not":[4],"an":[5,37],"inevitable":[6],"consequence":[7],"of":[8,19,43,57,97,141,188,200,204,208,214,233,248,257],"aging,":[9],"a":[10],"strong":[11],"association":[12,25],"exists":[13],"between":[14],"age":[15,53,87,115,154,184],"and":[16,108,121,128,143,161,167],"increasing":[17,52,139],"incidence":[18,187],"OA.":[20,189],"We":[21],"hypothesized":[22],"that":[23,50,169,194,253],"this":[24,71],"due":[27],"to":[28,46,64,90,163,219,236,242],"in":[29,40,77,86,157,170,180,197,206,224],"vivo":[30,171],"articular":[31,48,79,172,222],"cartilage":[32,80,173],"chondrocyte":[33,158,174,209,215,258],"senescence":[34,75,175,259],"which":[35],"causes":[36],"age-related":[38],"decline":[39],"the":[41,44,55,98,151,183,212,231,244,255],"ability":[42,63],"cells":[45],"maintain":[47],"cartilage,":[49],"is,":[51],"increases":[54],"risk":[56,199],"OA":[58,202,249],"because":[59,203],"chondrocytes":[60,81,235],"lose":[61],"their":[62,66,198],"replace":[65,261],"extracellular":[67],"matrix.":[68],"To":[69],"test":[70],"hypothesis,":[72],"we":[73],"measured":[74,104],"markers":[76,94],"human":[78],"from":[82,88],"27":[83],"donors":[84],"ranging":[85],"one":[89],"87":[91],"years.":[92],"The":[93,190],"included":[95],"expression":[96,112,140],"senescence-associated":[99],"enzyme":[100],"beta-galactosidase,":[101],"mitotic":[102,119,145],"activity":[103,120,160],"by":[105,230],"3H-thymidine":[106],"incorporation,":[107],"telomere":[109,123,133],"length.":[110],"beta-galactosidase":[111,142],"increased":[113,186],"with":[114,138],"(r=0.84,":[116],"p=0.0001)":[117],"while":[118],"mean":[122],"length":[124,134],"declined":[125],"(r=-0.774,":[126],"p=0.001":[127],"r=-0.71,":[129],"p=0.0004,":[130],"respectively).":[131],"Decreasing":[132],"was":[135],"strongly":[136],"correlated":[137],"decreasing":[144],"activity.":[146],"These":[147],"findings":[148],"help":[149],"explain":[150],"previously":[152],"reported":[153],"related":[155,185],"declines":[156],"synthetic":[159],"responsiveness":[162],"anabolic":[164],"growth":[165],"factors":[166],"indicate":[168],"responsible,":[177],"at":[178],"least":[179],"part,":[181],"for":[182],"data":[191],"also":[192],"imply":[193],"people":[195],"vary":[196],"developing":[201],"differences":[205],"onset":[207,256],"senescence;":[210],"and,":[211],"success":[213],"transplantation":[216],"procedures":[217],"performed":[218],"restore":[220],"damaged":[221],"surfaces":[223],"older":[225,234],"patients":[226],"could":[227],"be":[228],"limited":[229],"inability":[232],"form":[237],"new":[238],"cartilage.":[239],"New":[240],"efforts":[241],"prevent":[243],"development":[245],"or":[246,260],"progression":[247],"might":[250],"include":[251],"strategies":[252],"delay":[254],"senescent":[262],"cells.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
