{"id":"https://openalex.org/W1671154881","doi":null,"title":"Ascorbic Acid and Atherosclerosis","display_name":"Ascorbic Acid and Atherosclerosis","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1671154881","mag":"1671154881"},"language":"th","primary_location":{"id":"pmh:oai:li01.tci-thaijo.org:article/37301","doi":null,"is_oa":true,"landing_page_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/view/37301","pdf_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/37301/31027","source":{"id":"https://openalex.org/S7407065993","display_name":"Journal of Basic and Applied Pharmacology","issn_l":"2774-0854","issn":["2774-0854"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2774-0854","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/37301/31027","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037922575","display_name":"Uraiwan Ketsawatsakul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Uraiwan Ketsawatsakul","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, THAILAND. Tel: 4197569, 4115026"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, THAILAND. Tel: 4197569, 4115026","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045479052","display_name":"Pravit Akarasereenont","orcid":"https://orcid.org/0000-0001-5743-3251","observed_orcids":["https://orcid.org/0000-0001-5743-3251","https://orcid.org/0000-0001-9768-8347"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pravit Akarasereenont","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok10700THAILAND"],"raw_orcid":"https://orcid.org/0000-0001-5743-3251","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok10700THAILAND","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"1","first_page":"33","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":1.0},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.4390000104904175},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6629999876022339},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.800000011920929},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/monocyte-adhesion","display_name":"monocyte adhesion","score":0.656000018119812},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.7630000114440918},{"id":"https://openalex.org/keywords/vitamin-supplementation","display_name":"vitamin supplementation","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.9162173271179199},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6231403946876526},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6181579828262329},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5060276389122009},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49968981742858887},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4682886004447937},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.46369683742523193},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.45800185203552246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4542047679424286},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.44726741313934326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43870019912719727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4280715882778168},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4165087640285492},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.4152524173259735},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41086292266845703},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33823785185813904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3031764626502991},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2335560917854309},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.057092130184173584},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:li01.tci-thaijo.org:article/37301","doi":null,"is_oa":true,"landing_page_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/view/37301","pdf_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/37301/31027","source":{"id":"https://openalex.org/S7407065993","display_name":"Journal of Basic and Applied Pharmacology","issn_l":"2774-0854","issn":["2774-0854"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2774-0854","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1671154881","doi":null,"is_oa":false,"landing_page_url":"https://www.tci-thaijo.org/index.php/TJP/article/view/37301","pdf_url":null,"source":{"id":"https://openalex.org/S4306531941","display_name":"\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e27\u0e34\u0e17\u0e22\u0e32 (Thai Journal of Pharmacology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e27\u0e34\u0e17\u0e22\u0e32 (Thai Journal of Pharmacology)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:li01.tci-thaijo.org:article/37301","doi":null,"is_oa":true,"landing_page_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/view/37301","pdf_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/37301/31027","source":{"id":"https://openalex.org/S7407065993","display_name":"Journal of Basic and Applied Pharmacology","issn_l":"2774-0854","issn":["2774-0854"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2774-0854","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1671154881.pdf","grobid_xml":"https://content.openalex.org/works/W1671154881.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1512889873","https://openalex.org/W1560777399","https://openalex.org/W1622648453","https://openalex.org/W1725300350","https://openalex.org/W1857091480","https://openalex.org/W1963495254","https://openalex.org/W1965507115","https://openalex.org/W1981988093","https://openalex.org/W1988587584","https://openalex.org/W2001660885","https://openalex.org/W2005244961","https://openalex.org/W2035433779","https://openalex.org/W2037085202","https://openalex.org/W2038606821","https://openalex.org/W2052364512","https://openalex.org/W2062485846","https://openalex.org/W2064172838","https://openalex.org/W2080480505","https://openalex.org/W2088088730","https://openalex.org/W2092467967","https://openalex.org/W2096527916","https://openalex.org/W2134604571","https://openalex.org/W2162010936","https://openalex.org/W2163485744","https://openalex.org/W2180470224","https://openalex.org/W2187723987","https://openalex.org/W2419395790","https://openalex.org/W4406065675"],"related_works":["https://openalex.org/W133053936","https://openalex.org/W824322337","https://openalex.org/W2031455700","https://openalex.org/W2131058177","https://openalex.org/W2117995138","https://openalex.org/W2074030075","https://openalex.org/W1512889873","https://openalex.org/W2012548222","https://openalex.org/W2569035249","https://openalex.org/W374018946"],"abstract_inverted_index":{"The":[0],"role":[1,278],"of":[2,14,23,41,47,53,66,139,149,158,174,191,210,216,218,224,230,269,279],"ascorbic":[3,24,165,186,211,225,270,280],"acid":[4,25,166,212,226,281],"or":[5],"vitamin":[6,153],"C":[7],"has":[8,167,196],"been":[9,128,168,199],"proposed":[10],"in":[11,50,85,89,102,201,237,248,255,265,272,274,286],"the":[12,20,51,78,137,172,189,194,208,214,221,228,238,283],"prevention":[13,215],"atherosclerosis.The":[15],"possibility":[16],"is":[17,213],"discussed":[18],"that":[19,38,130],"antioxidant":[21,152],"effect":[22,195],"might":[26,243],"be":[27,46,116,253],"protective":[28],"against":[29],"and":[30,98,112,146,155,176,188,232],"possibly":[31],"propitious":[32],"to":[33,63,77,136,170,259],"atherosclerosis.":[34,249],"Growing":[35],"evidence":[36],"suggests":[37],"oxidative":[39,64,123],"modification":[40,65],"lowdensity":[42],"lipoprotein":[43],"(LDL)":[44],"may":[45,115],"particular":[48],"importance":[49],"pathogenesis":[52],"atherosclerosis":[54],"because":[55],"oxidized":[56,121],"LDL":[57,67,133,175],"exhibits":[58],"proatherogenic":[59],"effects.":[60],"In":[61,162],"addition":[62],"hypothesis,":[68],"inflammatory":[69],"process":[70],"potentiated":[71],"by":[72,118],"cytokines":[73],"also":[74],"importantly":[75],"contributes":[76],"pathogenesis.":[79],"These":[80,250],"complex":[81],"mechanisms":[82],"presumably":[83],"participate":[84],"endothelial":[86,246],"injury":[87],"resulting":[88],"impaired":[90],"releasing":[91],"factors,":[92],"such":[93],"as":[94,234,236],"nitric":[95],"oxide":[96],"(NO)":[97],"prostanoids,":[99],"taking":[100],"part":[101],"abnormal":[103],"vascular":[104],"tone.":[105],"Therefore,":[106],"vasoactive":[107],"substances":[108],"produced":[109],"from":[110],"endothelium":[111],"their":[113],"pathways":[114],"modulated":[117],"both":[119],"cytokines-and":[120],"LDL-induced":[122],"stress.":[124],"Recently,":[125],"antioxidants":[126],"have":[127],"determined":[129],"can":[131],"prevent":[132],"oxidation":[134,173,217],"beneficial":[135],"inhibition":[138],"atherosclerotic":[140,177],"process.There":[141],"are":[142],"accumulating":[143],"experimental,":[144],"epidemiological,":[145],"clinical":[147,202,266,287],"evidences":[148],"an":[150,182],"associationbetween":[151],"intake":[154,187],"reduced":[156],"risk":[157],"coronary":[159],"heart":[160],"disease.":[161],"animal":[163],"models,":[164],"shown":[169],"attenuate":[171],"lesions.":[178],"Population":[179],"studies":[180,258,268],"suggest":[181],"inverse":[183],"relationship":[184],"between":[185],"development":[190],"atherosclerosis,":[192],"although":[193],"not":[197],"yet":[198],"proven":[200],"trials.":[203],"A":[204],"possible":[205],"mechanism":[206],"for":[207,282],"antiatherogeniceffect":[209],"LDL.":[219],"Furthermore,":[220],"potential":[222],"effects":[223],"on":[227,240],"metabolism":[229],"NO":[231],"prostanoids":[233],"well":[235],"defense":[239],"monocyte":[241],"adherence":[242],"particularly":[244],"improve":[245],"function":[247],"finding":[251],"should":[252],"pursued":[254],"basic":[256],"research":[257],"elucidate":[260],"its":[261],"molecular":[262],"biological":[263],"mechanisms,additionally":[264],"epidemiological":[267],"supplementation":[271],"populations":[273],"order":[275],"toverify":[276],"a":[277],"practical":[284],"use":[285],"medicine.":[288]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}