{"id":"https://openalex.org/W1670790798","doi":null,"title":"Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes.","display_name":"Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes.","publication_year":2011,"publication_date":"2011-02-17","ids":{"openalex":"https://openalex.org/W1670790798","mag":"1670790798","pmid":"https://pubmed.ncbi.nlm.nih.gov/21365018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3042358"},"language":"en","primary_location":{"id":"pmid:21365018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21365018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3042358/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033789977","display_name":"Ahmed M. Abu El\u2010Asrar","orcid":"https://orcid.org/0000-0003-2226-8617","observed_orcids":["https://orcid.org/0000-0003-2226-8617"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ahmed M Abu El-Asrar","raw_affiliation_strings":["Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. abuasrar@KSU.edu.sa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. abuasrar@KSU.edu.sa","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080029758","display_name":"L Missotten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luc Missotten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084134209","display_name":"Karel J. Geboes","orcid":"https://orcid.org/0000-0003-1132-1080","observed_orcids":["https://orcid.org/0000-0003-1132-1080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karel Geboes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.025,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.94881557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":null,"first_page":"508","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.21860000491142273,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.7960000038146973},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.8730000257492065},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/epiretinal-membrane","display_name":"epiretinal membrane","score":0.8379999995231628},{"id":"https://openalex.org/keywords/proliferative-diabetic-retinopathy","display_name":"proliferative diabetic retinopathy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/proliferative-vitreoretinopathy","display_name":"proliferative vitreoretinopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8479999899864197},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6850000023841858},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.746999979019165},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.6690000295639038},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2779059073","wikidata":"https://www.wikidata.org/wiki/Q7249608","display_name":"Proliferative vitreoretinopathy","level":4,"score":0.8017397522926331},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.7842820882797241},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.7358930110931396},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.7217608094215393},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.7063277363777161},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.5603952407836914},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5281004309654236},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5191930532455444},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4479604661464691},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44232383370399475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42454224824905396},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4163416624069214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37384817004203796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35785916447639465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3173114061355591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29255783557891846},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28751689195632935},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.18677347898483276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1403665840625763},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.11472243070602417},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.05891662836074829},{"id":"https://openalex.org/C2780428090","wikidata":"https://www.wikidata.org/wiki/Q625164","display_name":"Retinal detachment","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019773","descriptor_name":"Epiretinal Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019773","descriptor_name":"Epiretinal Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:21365018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21365018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3042358","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3042358/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:1670790798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21365018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3042358","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3042358/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1551118958","https://openalex.org/W1597543466","https://openalex.org/W1969244496","https://openalex.org/W1980325398","https://openalex.org/W1981895579","https://openalex.org/W1984939059","https://openalex.org/W1986585280","https://openalex.org/W1988975320","https://openalex.org/W2001546115","https://openalex.org/W2003295957","https://openalex.org/W2021882325","https://openalex.org/W2023974524","https://openalex.org/W2024500714","https://openalex.org/W2028127681","https://openalex.org/W2028294482","https://openalex.org/W2034667484","https://openalex.org/W2038776268","https://openalex.org/W2050147761","https://openalex.org/W2059217150","https://openalex.org/W2066650638","https://openalex.org/W2070577035","https://openalex.org/W2073547276","https://openalex.org/W2077654695","https://openalex.org/W2080660353","https://openalex.org/W2083790597","https://openalex.org/W2088780149","https://openalex.org/W2096401506","https://openalex.org/W2101153911","https://openalex.org/W2120194682","https://openalex.org/W2120276758","https://openalex.org/W2122098632","https://openalex.org/W2127730885","https://openalex.org/W2128945729","https://openalex.org/W2129902595","https://openalex.org/W2133864129","https://openalex.org/W2134541063","https://openalex.org/W2134871534","https://openalex.org/W2136005561","https://openalex.org/W2137064182","https://openalex.org/W2137888957","https://openalex.org/W2141461285","https://openalex.org/W2144659434","https://openalex.org/W2145992607","https://openalex.org/W2150989762","https://openalex.org/W2159786641","https://openalex.org/W2160546785","https://openalex.org/W2161793406","https://openalex.org/W2162425800","https://openalex.org/W2167443327","https://openalex.org/W2171296456"],"related_works":["https://openalex.org/W2096607602","https://openalex.org/W2088780149","https://openalex.org/W2967127565","https://openalex.org/W2073547276","https://openalex.org/W1976456061","https://openalex.org/W2099106905","https://openalex.org/W3129182228","https://openalex.org/W7098797082","https://openalex.org/W2774674482","https://openalex.org/W2096982267"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,135,180],"high-mobility":[2],"group":[3],"box":[4],"-1":[5],"(HMGB1)/receptor":[6],"for":[7],"advanced":[8],"glycation":[9],"end":[10],"products":[11],"(RAGE)/osteopontin":[12],"(OPN)/early":[13],"growth":[14],"response-1":[15],"(Egr-1)":[16],"pathway":[17,34,182],"is":[18],"involved":[19,185],"in":[20,35,81,97,157,161,186,192],"inflammation,":[21],"angiogenesis,":[22],"and":[23,40,49,57,79,85,95,101,121,127,133,140,147,149,177,189],"fibrosis.":[24],"We":[25],"investigated":[26],"the":[27,30,110,116,122],"expression":[28],"of":[29,32,112,124,137],"components":[31],"this":[33],"proliferative":[36,41,193],"diabetic":[37],"retinopathy":[38],"(PDR)":[39],"vitreoretinopathy":[42],"(PVR)":[43],"epiretinal":[44],"membranes.":[45,163],"METHODS:":[46],"Nine":[47],"active":[48,158],"13":[50],"inactive":[51,162],"membranes":[52,59,159],"from":[53,60],"patients":[54,61],"with":[55,62],"PDR":[56,70],"21":[58],"PVR":[63,165],"were":[64,107,154],"studied":[65],"by":[66],"immunohistochemistry.":[67],"RESULTS:":[68],"In":[69,164],"membranes,":[71,87,103,166],"vascular":[72],"endothelial":[73],"cells":[74,90,129,142,151],"expressed":[75,91],"HMGB1,":[76,92,131,145,174],"RAGE,":[77,93,132,146,175],"OPN,":[78,94,176],"Egr-1":[80,96,153],"21,":[82,98],"15,":[83],"20,":[84,99,100],"16":[86,102],"respectively.":[88,104],"Stromal":[89],"Significant":[105],"correlations":[106],"detected":[108],"between":[109],"number":[111,123],"blood":[113,125,138],"vessels":[114,126,139],"expressing":[115,130,143,152,169],"panendothelial":[117],"cell":[118],"marker":[119],"CD34":[120],"stromal":[128,141,150],"OPN.":[134],"numbers":[136],"CD34,":[144],"OPN":[148],"significantly":[155],"higher":[156],"than":[160],"spindle-shaped":[167],"myofibroblasts":[168],"\u03b1-smooth":[170],"muscle":[171],"actin":[172],"coexpressed":[173],"Egr-1.":[178],"CONCLUSIONS:":[179],"HMGB1/RAGE/OPN/Egr-1":[181],"may":[183],"be":[184],"inflammatory,":[187],"angiogenic":[188],"fibrotic":[190],"responses":[191],"vitreoretinal":[194],"disorders.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
