{"id":"https://openalex.org/W167047154","doi":"https://doi.org/10.1002/cpt19741661052","title":"Pharmacokinetics of tolbutamide: Prediction by concentration in saliva","display_name":"Pharmacokinetics of tolbutamide: Prediction by concentration in saliva","publication_year":1974,"publication_date":"1974-12-01","ids":{"openalex":"https://openalex.org/W167047154","doi":"https://doi.org/10.1002/cpt19741661052","mag":"167047154","pmid":"https://pubmed.ncbi.nlm.nih.gov/4433472"},"language":"en","primary_location":{"id":"doi:10.1002/cpt19741661052","doi":"https://doi.org/10.1002/cpt19741661052","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt19741661052","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006853244","display_name":"Shaikh B. Matin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaikh B. Matin","raw_affiliation_strings":["Schools of Pharmacy and Medicine, University of California, and Clinical Pharmacology-Toxicology Center, University of Kansas Medical Center, San Francisco, Calif., and Kansas City, Kan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schools of Pharmacy and Medicine, University of California, and Clinical Pharmacology-Toxicology Center, University of Kansas Medical Center, San Francisco, Calif., and Kansas City, Kan","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520553","display_name":"Suk Han Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suk Han Wan","raw_affiliation_strings":["Schools of Pharmacy and Medicine, University of California, and Clinical Pharmacology-Toxicology Center, University of Kansas Medical Center, San Francisco, Calif., and Kansas City, Kan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schools of Pharmacy and Medicine, University of California, and Clinical Pharmacology-Toxicology Center, University of Kansas Medical Center, San Francisco, Calif., and Kansas City, Kan","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112778549","display_name":"John H. Karam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Karam","raw_affiliation_strings":["Schools of Pharmacy and Medicine, University of California, and Clinical Pharmacology-Toxicology Center, University of Kansas Medical Center, San Francisco, Calif., and Kansas City, Kan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schools of Pharmacy and Medicine, University of California, and Clinical Pharmacology-Toxicology Center, University of Kansas Medical Center, San Francisco, Calif., and Kansas City, Kan","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":5.2446,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.96473118,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"16","issue":"6","first_page":"1052","last_page":"1058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.22339999675750732,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.22339999675750732,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.20649999380111694,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.19140000641345978,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tolbutamide","display_name":"tolbutamide","score":1.0},{"id":"https://openalex.org/keywords/salivary-drug-concentration","display_name":"salivary drug concentration","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pharmacokinetic-prediction","display_name":"pharmacokinetic prediction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-excretion","display_name":"drug excretion","score":0.6290000081062317},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ionization","display_name":"ionization","score":0.8550000190734863},{"id":"https://openalex.org/keywords/diabetic-patients","display_name":"diabetic patients","score":0.671999990940094},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.9919348955154419},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.9172627925872803},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8187528848648071},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6522567272186279},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47320669889450073},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.43764957785606384},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4237367510795593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37934067845344543},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3499554395675659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20098599791526794},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.18092221021652222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14976829290390015}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cpt19741661052","doi":"https://doi.org/10.1002/cpt19741661052","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt19741661052","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:4433472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4433472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400659280","https://openalex.org/W2084052997","https://openalex.org/W2078665307","https://openalex.org/W81678675","https://openalex.org/W2111059556","https://openalex.org/W2158382776","https://openalex.org/W1994740999","https://openalex.org/W1965261731","https://openalex.org/W2131368941","https://openalex.org/W2320490428"],"abstract_inverted_index":{"The":[0],"excretion":[1,68],"of":[2,6,13,58,74,79,81,88],"tolbutamide":[3,16,38,47,82],"in":[4,49,52,69,83,99],"saliva":[5,50,70,90],"diabetic":[7],"patients":[8],"receiving":[9],"single":[10],"intravenous":[11],"doses":[12],"1":[14],"gm":[15],"is":[17],"described.":[18],"Gas":[19],"chromatography":[20],"with":[21],"electron":[22],"capture":[23],"was":[24,41,95],"used":[25],"for":[26,66],"analysis.":[27],"Pharmacokinetic":[28],"parameters":[29],"could":[30],"be":[31],"obtained":[32],"from":[33],"either":[34],"salivary":[35,54],"or":[36],"plasma":[37,59,84,92],"levels.":[39,60],"There":[40],"a":[42],"good":[43],"linear":[44],"relationship":[45],"between":[46],"concentration":[48,93],"and":[51,77,85],"plasma;":[53],"levels":[55],"were":[56],"1.2%":[57],"Equations":[61],"are":[62],"presented":[63],"that":[64],"account":[65],"the":[67,89,100],"based":[71],"on":[72,102],"extent":[73],"protein":[75],"binding":[76],"degree":[78],"ionization":[80],"saliva.":[86],"Correlation":[87],"to":[91,97],"ratio":[94],"extended":[96],"data":[98],"literature":[101],"two":[103],"other":[104],"drugs.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
