{"id":"https://openalex.org/W166998358","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.660.12","title":"Interaction of Hepatocyte nuclear factor 4alpha (HNF4alpha) with the TATA box binding protein (TBP) contributes to TFIID recruitment and HNF4alpha dependent transcription","display_name":"Interaction of Hepatocyte nuclear factor 4alpha (HNF4alpha) with the TATA box binding protein (TBP) contributes to TFIID recruitment and HNF4alpha dependent transcription","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W166998358","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.660.12","mag":"166998358"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.660.12","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.660.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.660.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045899068","display_name":"Hidehisa Takahashi","orcid":"https://orcid.org/0000-0001-7181-9863","observed_orcids":["https://orcid.org/0000-0001-7181-9863"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidehisa Takahashi","raw_affiliation_strings":["Stowers Institute for Medical Research Kansas City MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research Kansas City MO","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066752773","display_name":"Skylar Martin\u2010Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skylar Martin\u2010Brown","raw_affiliation_strings":["Stowers Institute for Medical Research Kansas City MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research Kansas City MO","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034566006","display_name":"Michael P. Washburn","orcid":"https://orcid.org/0000-0001-7568-2585","observed_orcids":["https://orcid.org/0000-0001-7568-2585"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Washburn","raw_affiliation_strings":["Stowers Institute for Medical Research Kansas City MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research Kansas City MO","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079392980","display_name":"Laurence A. Florens","orcid":"https://orcid.org/0000-0002-9310-6650","observed_orcids":["https://orcid.org/0000-0002-9310-6650"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Florens","raw_affiliation_strings":["Stowers Institute for Medical Research Kansas City MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research Kansas City MO","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060208809","display_name":"Joan Weliky Conaway","orcid":"https://orcid.org/0000-0002-2786-0663","observed_orcids":["https://orcid.org/0000-0002-2786-0663"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan W. Conaway","raw_affiliation_strings":["Stowers Institute for Medical Research Kansas City MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research Kansas City MO","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054486813","display_name":"Ronald  C. Conaway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C. Conaway","raw_affiliation_strings":["Stowers Institute for Medical Research Kansas City MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research Kansas City MO","institution_ids":["https://openalex.org/I114131015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114131015"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01429308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hnf4a","display_name":"HNF4\u03b1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tfiid","display_name":"TFIID","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.6489999890327454},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.6050000190734863},{"id":"https://openalex.org/keywords/promoter-recruitment","display_name":"promoter recruitment","score":0.7670000195503235},{"id":"https://openalex.org/keywords/glucose-and-lipid-metabolism","display_name":"glycolipid metabolism","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C44498088","wikidata":"https://www.wikidata.org/wiki/Q14878255","display_name":"Transcription factor II A","level":5,"score":0.7400274276733398},{"id":"https://openalex.org/C2909959438","wikidata":"https://www.wikidata.org/wiki/Q14878262","display_name":"TATA-Box Binding Protein","level":5,"score":0.7235132455825806},{"id":"https://openalex.org/C172768829","wikidata":"https://www.wikidata.org/wiki/Q14817959","display_name":"Transcription factor II D","level":5,"score":0.6886265277862549},{"id":"https://openalex.org/C99535661","wikidata":"https://www.wikidata.org/wiki/Q5731779","display_name":"Hepatocyte nuclear factors","level":4,"score":0.5925270915031433},{"id":"https://openalex.org/C144825837","wikidata":"https://www.wikidata.org/wiki/Q2316030","display_name":"General transcription factor","level":5,"score":0.5822321772575378},{"id":"https://openalex.org/C146027311","wikidata":"https://www.wikidata.org/wiki/Q18031820","display_name":"TAF2","level":5,"score":0.5762660503387451},{"id":"https://openalex.org/C2780055153","wikidata":"https://www.wikidata.org/wiki/Q14878262","display_name":"TATA-binding protein","level":5,"score":0.5676962733268738},{"id":"https://openalex.org/C65888428","wikidata":"https://www.wikidata.org/wiki/Q1413955","display_name":"TATA box","level":5,"score":0.5204303860664368},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4613412022590637},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4565829634666443},{"id":"https://openalex.org/C105208137","wikidata":"https://www.wikidata.org/wiki/Q425812","display_name":"Transcription factor II B","level":5,"score":0.4324818551540375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43022334575653076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42125606536865234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3378438949584961},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.24943512678146362},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.16721111536026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15396040678024292},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07537427544593811}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.660.12","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.660.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.660.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044214776","https://openalex.org/W2138910677","https://openalex.org/W2007722784","https://openalex.org/W7096041268","https://openalex.org/W2126319554","https://openalex.org/W2039307052","https://openalex.org/W2033549688","https://openalex.org/W1972027666","https://openalex.org/W7095687326","https://openalex.org/W4402852936"],"abstract_inverted_index":{"HNF4alpha,":[0],"a":[1,9,114,131],"member":[2],"of":[3,13,30,37,113,147],"nuclear":[4],"hormone":[5],"receptor":[6],"superfamily,":[7],"is":[8],"key":[10],"transcriptional":[11],"regulator":[12],"many":[14],"genes":[15],"that":[16,68,90,125,144],"control":[17],"glucose":[18],"and":[19,36,50,62],"lipid":[20],"metabolism.":[21],"We":[22,65],"have":[23,66],"identified":[24],"HNF4alpha":[25,43,54,71,87,126,148],"as":[26],"an":[27,77],"interaction":[28,146],"partner":[29],"the":[31,59,142,145],"general":[32],"transcription":[33,129,135],"factor":[34],"TFIID":[35,73,101],"its":[38],"TATA\u2010box":[39],"binding":[40,61],"subunit":[41],"TBP.":[42,85],"binds":[44],"directly":[45],"to":[46,76,92,102,152],"TBP":[47,75,95,99,150],"in":[48,51,69,104,117,130],"vitro":[49],"vivo":[52],"through":[53,80],"residues":[55],"52\u2010174,":[56],"which":[57],"include":[58],"DNA":[60],"hinge":[63],"domains.":[64],"demonstrated":[67],"vitro,":[70],"recruits":[72],"or":[74,100],"immobilized":[78],"template":[79],"direct":[81],"physical":[82],"interactions":[83],"with":[84,94,110,122,141,149],"An":[86],"point":[88],"mutant":[89],"fails":[91],"interact":[93],"does":[96],"not":[97],"recruit":[98],"promoters":[103],"vitro.":[105],"The":[106],"same":[107],"mutation":[108],"interferes":[109],"HNF4alpha\u2010dependent":[111],"activation":[112],"reporter":[115],"gene":[116],"vivo.":[118],"These":[119],"observations,":[120],"together":[121],"results":[123],"indicating":[124],"can":[127],"activate":[128],"highly":[132],"purified,":[133],"reconstituted":[134],"system":[136],"lacking":[137],"coregulators,":[138],"are":[139],"consistent":[140],"model":[143],"contributes":[151],"HNF4alpha\u2010induced":[153],"transcription.":[154]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
