{"id":"https://openalex.org/W1669972939","doi":"https://doi.org/10.1155/2016/7095901","title":"Critical Roles of Reactive Oxygen Species in Age\u2010Related Impairment in Ischemia\u2010Induced Neovascularization by Regulating Stem and Progenitor Cell Function","display_name":"Critical Roles of Reactive Oxygen Species in Age\u2010Related Impairment in Ischemia\u2010Induced Neovascularization by Regulating Stem and Progenitor Cell Function","publication_year":2015,"publication_date":"2015-11-30","ids":{"openalex":"https://openalex.org/W1669972939","doi":"https://doi.org/10.1155/2016/7095901","mag":"1669972939","pmid":"https://pubmed.ncbi.nlm.nih.gov/26697140","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4677240"},"language":"en","primary_location":{"id":"doi:10.1155/2016/7095901","doi":"https://doi.org/10.1155/2016/7095901","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/7095901","pdf_url":null,"source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1155/2016/7095901","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066840342","display_name":"Yuen Ting Lam","orcid":"https://orcid.org/0000-0002-2819-5407","observed_orcids":["https://orcid.org/0000-0002-2819-5407"]},"institutions":[{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Yuen Ting Lam","raw_affiliation_strings":["The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia","institution_ids":["https://openalex.org/I2801241159"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066840342"],"corresponding_institution_ids":["https://openalex.org/I2801241159"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":0.2241,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.16082961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2016","issue":"1","first_page":"7095901","last_page":"7095901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.14139999449253082,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6209999918937683},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stem-cell-function","display_name":"stem cell function","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cell-mobilization","display_name":"cell mobilization","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7095375061035156},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7004481554031372},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6838216781616211},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6521481871604919},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5551702976226807},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5511590242385864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5248416066169739},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5235167145729065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40537264943122864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33788830041885376},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3352794647216797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27646365761756897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17040076851844788}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1155/2016/7095901","doi":"https://doi.org/10.1155/2016/7095901","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/7095901","pdf_url":null,"source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3661907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4677240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4677240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4677240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxid Med Cell Longev","raw_type":"Text"},{"id":"pmid:26697140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26697140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative medicine and cellular longevity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.8362","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.8362","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c2/ab/OMCL2016-7095901.PMC4677240.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3a8ce5a12abf4fe18e79317b1e4102ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3a8ce5a12abf4fe18e79317b1e4102ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2016/7095901","doi":"https://doi.org/10.1155/2016/7095901","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/7095901","pdf_url":null,"source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320966","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W82391255","https://openalex.org/W1568791514","https://openalex.org/W1664379753","https://openalex.org/W1966780233","https://openalex.org/W1967351404","https://openalex.org/W1968261821","https://openalex.org/W1970191803","https://openalex.org/W1970634781","https://openalex.org/W1971218073","https://openalex.org/W1973577066","https://openalex.org/W1974812650","https://openalex.org/W1982861439","https://openalex.org/W1984190184","https://openalex.org/W1985749260","https://openalex.org/W1986419239","https://openalex.org/W1986991023","https://openalex.org/W1987652531","https://openalex.org/W1987672321","https://openalex.org/W1990787920","https://openalex.org/W1991835908","https://openalex.org/W1991962444","https://openalex.org/W1995091371","https://openalex.org/W1995845964","https://openalex.org/W1995886345","https://openalex.org/W1996181447","https://openalex.org/W1999481518","https://openalex.org/W1999705679","https://openalex.org/W2002173046","https://openalex.org/W2002305938","https://openalex.org/W2003996125","https://openalex.org/W2004427135","https://openalex.org/W2004829381","https://openalex.org/W2004857262","https://openalex.org/W2009184449","https://openalex.org/W2009293798","https://openalex.org/W2009621718","https://openalex.org/W2010913383","https://openalex.org/W2017430539","https://openalex.org/W2017965105","https://openalex.org/W2018694503","https://openalex.org/W2022572059","https://openalex.org/W2026316162","https://openalex.org/W2026587757","https://openalex.org/W2026998209","https://openalex.org/W2032767070","https://openalex.org/W2038543378","https://openalex.org/W2039374791","https://openalex.org/W2041897873","https://openalex.org/W2044327891","https://openalex.org/W2044961448","https://openalex.org/W2045907249","https://openalex.org/W2046253273","https://openalex.org/W2048861298","https://openalex.org/W2050560941","https://openalex.org/W2053277760","https://openalex.org/W2053442159","https://openalex.org/W2053704719","https://openalex.org/W2054271984","https://openalex.org/W2055118292","https://openalex.org/W2056351644","https://openalex.org/W2057989547","https://openalex.org/W2058906518","https://openalex.org/W2061990870","https://openalex.org/W2062173751","https://openalex.org/W2073429636","https://openalex.org/W2073692681","https://openalex.org/W2074242691","https://openalex.org/W2077662795","https://openalex.org/W2080095504","https://openalex.org/W2083460692","https://openalex.org/W2084289371","https://openalex.org/W2089039447","https://openalex.org/W2089780116","https://openalex.org/W2091791553","https://openalex.org/W2096493223","https://openalex.org/W2098266872","https://openalex.org/W2099348677","https://openalex.org/W2101875402","https://openalex.org/W2102744645","https://openalex.org/W2103914401","https://openalex.org/W2105241495","https://openalex.org/W2107689453","https://openalex.org/W2110419512","https://openalex.org/W2111004371","https://openalex.org/W2112792041","https://openalex.org/W2117155507","https://openalex.org/W2117427183","https://openalex.org/W2123163588","https://openalex.org/W2123963680","https://openalex.org/W2125635123","https://openalex.org/W2126110575","https://openalex.org/W2127289319","https://openalex.org/W2127296141","https://openalex.org/W2128507677","https://openalex.org/W2130761693","https://openalex.org/W2131109804","https://openalex.org/W2132638049","https://openalex.org/W2132673369","https://openalex.org/W2133274841","https://openalex.org/W2135470678","https://openalex.org/W2135503492","https://openalex.org/W2135932320","https://openalex.org/W2139514988","https://openalex.org/W2139793134","https://openalex.org/W2141138595","https://openalex.org/W2145319267","https://openalex.org/W2146064444","https://openalex.org/W2146159580","https://openalex.org/W2153531211","https://openalex.org/W2154360613","https://openalex.org/W2155857605","https://openalex.org/W2156006656","https://openalex.org/W2162106476","https://openalex.org/W2162989910","https://openalex.org/W2163087495","https://openalex.org/W2163807262","https://openalex.org/W2170871745","https://openalex.org/W2223421358","https://openalex.org/W2315512556","https://openalex.org/W2638561866","https://openalex.org/W3015544325","https://openalex.org/W4251403705"],"related_works":["https://openalex.org/W7100560718","https://openalex.org/W2132638049","https://openalex.org/W982729389","https://openalex.org/W1988087076","https://openalex.org/W2512968756","https://openalex.org/W2128507677","https://openalex.org/W2491237175","https://openalex.org/W2153059526","https://openalex.org/W3204324914","https://openalex.org/W1987652531"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"regulate":[4],"bone":[5,41],"marrow":[6,42],"microenvironment":[7],"for":[8,131],"stem":[9,88,122],"and":[10,17,75,89,103,123],"progenitor":[11,36,90,124],"cells":[12,37,125],"functions":[13],"including":[14],"self-renewal,":[15],"differentiation,":[16],"cell":[18,91],"senescence.":[19],"In":[20],"response":[21],"to":[22,43,51,126],"ischemia,":[23],"ROS":[24,85,98],"also":[25],"play":[26],"a":[27,62],"critical":[28],"role":[29],"in":[30,65,86,109],"mediating":[31],"the":[32,40,44,82,94,104,118,128],"mobilization":[33],"of":[34,46,84,96,121],"endothelial":[35],"(EPCs)":[38],"from":[39],"sites":[45],"ischemic":[47],"injury,":[48],"which":[49],"contributes":[50],"postnatal":[52],"neovascularization.":[53,78,111],"Aging":[54],"is":[55,69],"an":[56],"unavoidable":[57],"biological":[58],"deteriorative":[59],"process":[60],"with":[61,71,106,134],"progressive":[63],"decline":[64],"physiological":[66],"functions.":[67],"It":[68],"associated":[70],"increased":[72],"oxidative":[73,119],"stress":[74],"impaired":[76],"ischemia-induced":[77,110],"This":[79],"review":[80],"discusses":[81,114],"roles":[83],"regulating":[87],"function,":[92],"highlighting":[93],"impact":[95],"unbalanced":[97],"levels":[99,120],"on":[100],"EPC":[101],"dysfunction":[102],"association":[105],"age-related":[107],"impairment":[108],"Furthermore,":[112],"it":[113],"strategies":[115],"that":[116],"modulate":[117],"enhance":[127],"therapeutic":[129],"potential":[130],"elderly":[132],"patients":[133],"cardiovascular":[135],"disease.":[136]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}