{"id":"https://openalex.org/W1668912007","doi":null,"title":"Regulaci\u00f3n del factor de transcripci\u00f3n GATA3 por progest\u00e1genos y su participaci\u00f3n en la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de mama","display_name":"Regulaci\u00f3n del factor de transcripci\u00f3n GATA3 por progest\u00e1genos y su participaci\u00f3n en la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de mama","publication_year":2015,"publication_date":"2015-03-30","ids":{"openalex":"https://openalex.org/W1668912007","mag":"1668912007"},"language":"es","primary_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5710_Izzo_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.12110/tesis_n5710_Izzo","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038258515","display_name":"Franco Izzo","orcid":"https://orcid.org/0000-0002-5813-6504","observed_orcids":["https://orcid.org/0000-0002-5813-6504"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Franco Izzo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5813-6504","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038258515"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.09220000356435776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.9390000104904175},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.8399999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.7429999709129333},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9079999923706055},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.800000011920929},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8240000009536743},{"id":"https://openalex.org/keywords/26s-proteasome-degradation","display_name":"26S proteasome degradation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cyclin-a2","display_name":"cyclin A2","score":0.972000002861023},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.4909999966621399},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5718504190444946},{"id":"https://openalex.org/C102037460","wikidata":"https://www.wikidata.org/wiki/Q18025464","display_name":"GATA3","level":4,"score":0.4530583620071411},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.38235563039779663},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3462955951690674},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.2834283709526062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19239124655723572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5710_Izzo_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:3853389","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12110/tesis_n5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:snrd:Tesis_5710_Izzo","doi":null,"is_oa":true,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&c=tesis&d=Tesis_5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:tesis:tesis_n5710_Izzo","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:RDI UBA:aextesis:Tesis_5710_Izzo_oai","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&c=tesis&d=Tesis_5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Tesis Doctoral"},{"id":"mag:1668912007","doi":null,"is_oa":false,"landing_page_url":"https://bibliotecadigital.exactas.uba.ar/download/tesis/tesis_n5710_Izzo.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5710_Izzo_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5710_Izzo","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W73763563","https://openalex.org/W1504034854","https://openalex.org/W1542090274","https://openalex.org/W1544564404","https://openalex.org/W1569704074","https://openalex.org/W1578883980","https://openalex.org/W1964081894","https://openalex.org/W1976739900","https://openalex.org/W1977090021","https://openalex.org/W1977934858","https://openalex.org/W1980003489","https://openalex.org/W1981472752","https://openalex.org/W1985054310","https://openalex.org/W1986381098","https://openalex.org/W1996487270","https://openalex.org/W1996735209","https://openalex.org/W1998398174","https://openalex.org/W1999668102","https://openalex.org/W2000781313","https://openalex.org/W2004798786","https://openalex.org/W2006840767","https://openalex.org/W2010065461","https://openalex.org/W2013956549","https://openalex.org/W2015446431","https://openalex.org/W2017490712","https://openalex.org/W2018982129","https://openalex.org/W2024373518","https://openalex.org/W2027073895","https://openalex.org/W2027988818","https://openalex.org/W2033478449","https://openalex.org/W2036638605","https://openalex.org/W2040762618","https://openalex.org/W2041313987","https://openalex.org/W2045753672","https://openalex.org/W2045959839","https://openalex.org/W2051325494","https://openalex.org/W2053116646","https://openalex.org/W2057292695","https://openalex.org/W2061996967","https://openalex.org/W2062034356","https://openalex.org/W2062059447","https://openalex.org/W2064879068","https://openalex.org/W2066284955","https://openalex.org/W2066499827","https://openalex.org/W2073131935","https://openalex.org/W2076448756","https://openalex.org/W2078802143","https://openalex.org/W2079611570","https://openalex.org/W2082559087","https://openalex.org/W2082959814","https://openalex.org/W2086745302","https://openalex.org/W2089019735","https://openalex.org/W2094891822","https://openalex.org/W2095002834","https://openalex.org/W2095471691","https://openalex.org/W2096977686","https://openalex.org/W2097255042","https://openalex.org/W2099737493","https://openalex.org/W2102701881","https://openalex.org/W2109424338","https://openalex.org/W2113260405","https://openalex.org/W2116374810","https://openalex.org/W2117326208","https://openalex.org/W2118203903","https://openalex.org/W2119525258","https://openalex.org/W2119801679","https://openalex.org/W2121456510","https://openalex.org/W2123293204","https://openalex.org/W2125496315","https://openalex.org/W2128181270","https://openalex.org/W2128624246","https://openalex.org/W2129353515","https://openalex.org/W2136866084","https://openalex.org/W2139118454","https://openalex.org/W2139866384","https://openalex.org/W2145999402","https://openalex.org/W2146422464","https://openalex.org/W2148131050","https://openalex.org/W2148157474","https://openalex.org/W2154533342","https://openalex.org/W2155916082","https://openalex.org/W2160946478","https://openalex.org/W2167132998","https://openalex.org/W2168164762","https://openalex.org/W2169719363","https://openalex.org/W2200093255","https://openalex.org/W2221671834","https://openalex.org/W2515721699","https://openalex.org/W7074230359","https://openalex.org/W7135390683"],"related_works":["https://openalex.org/W2123293204","https://openalex.org/W2063011856","https://openalex.org/W2736866420","https://openalex.org/W7098201013","https://openalex.org/W2277860036","https://openalex.org/W91131356","https://openalex.org/W2950970876","https://openalex.org/W1975512744","https://openalex.org/W2242646233","https://openalex.org/W2807886628"],"abstract_inverted_index":{"El":[0,28],"factor":[1],"de":[2,12,24,30,34,43,47,50,52,71,77,79,91,96,98,102,111,119,124,133,136,164,168,170,184,194,202,220,222,228,231],"transcripci\u00f3n":[3],"maestro":[4],"GATA3":[5,31,53,165,185,232],"se":[6,128,212],"encuentra":[7,129,213],"involucrado":[8],"en":[9,32,117,145,166,181,218],"el":[10,19,45,60,63,75,146,189,241],"desarrollo":[11],"laglandula":[13],"mamaria":[14],"y":[15,211],"es":[16,54,186],"requerido":[17],"para":[18,235],"mantenimiento":[20],"del":[21,69,89,122,208],"estado":[22],"diferenciado":[23],"lasc\u00e9lulas":[25],"epiteliales":[26],"luminales.":[27],"rol":[29],"c\u00e1ncer":[33,169,221],"mama":[35,171],"como":[36],"supresortumoral":[37],"ha":[38,56],"sido":[39,57],"establecido,":[40],"a":[41,206,215],"pesar":[42],"que":[44,178,226],"mecanismo":[46],"la":[48,67,99,103,109,112,134,137,141,162,173,179,195,198,203,236],"p\u00e9rdida":[49],"expresi\u00f3n":[51,163],"no":[55],"descrito":[58],"hasta":[59],"momento.":[61],"En":[62],"presente":[64],"trabajo,":[65],"demostramosque":[66],"activaci\u00f3n":[68],"Receptor":[70],"Progesterona":[72],"(RP)":[73],"promueve":[74],"co-reclutamiento":[76],"lametiltransferasa":[78],"histonas":[80],"Enhancer":[81],"of":[82],"Zeste":[83],"Homolog":[84],"2":[85],"(EZH2)":[86],"r\u00edo":[87],"arriba":[88],"locus":[90],"GATA3,":[92,139],"incrementando":[93],"los":[94,120,182,229],"niveles":[95,121,183,230],"trimetilaci\u00f3n":[97],"lisina":[100],"27":[101],"histona":[104],"H3":[105],"(H3K27me3)":[106],"e":[107],"induciendo":[108],"compactaci\u00f3n":[110],"cromatina,":[113],"lo":[114],"cual":[115,199],"resulta":[116],"ladisminuci\u00f3n":[118,227],"ARNm":[123],"GATA3.":[125],"Esta":[126],"regulaci\u00f3n":[127],"acopladaa":[130],"una":[131],"disminuci\u00f3n":[132],"estabilidad":[135],"prote\u00edna":[138],"mediante":[140],"fosforilaci\u00f3ninducida":[142],"por":[143,192,247],"progest\u00e1genos":[144,193],"residuo":[147],"serina":[148],"308":[149],"(pSer308-GATA3),":[150],"seguida":[151],"pordegradaci\u00f3n":[152],"v\u00eda":[153],"proteasoma":[154],"26S.":[155],"Ambos":[156],"mecanismos":[157],"moleculares":[158],"convergen":[159],"paralograr":[160],"reducir":[161],"c\u00e9lulas":[167],"tras":[172],"activaci\u00f3ndel":[174],"RP.":[175],"Adem\u00e1s,":[176],"demostramos":[177,225],"reducci\u00f3n":[180],"requeridapara":[187],"lograr":[188],"incremento":[190],"inducido":[191],"ciclina":[196],"A2,":[197],"media":[200],"latransici\u00f3n":[201],"fase":[204],"G1":[205],"S":[207],"ciclo":[209],"celular,":[210],"asociada":[214],"un":[216],"peorpron\u00f3stico":[217],"pacientes":[219],"mama.":[223],"Finalmente,":[224],"son":[233],"necesarios":[234],"proliferaci\u00f3n":[237],"celular":[238],"in":[239,244],"vitroy":[240],"crecimiento":[242],"tumoral":[243],"vivo":[245],"inducidos":[246],"progest\u00e1genos.":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}