{"id":"https://openalex.org/W1667979288","doi":null,"title":"[Copy number variation: markers and predictors for type 2 diabetes].","display_name":"[Copy number variation: markers and predictors for type 2 diabetes].","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W1667979288","mag":"1667979288","pmid":"https://pubmed.ncbi.nlm.nih.gov/25984620"},"language":"es","primary_location":{"id":"pmid:25984620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25984620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica del Instituto Mexicano del Seguro Social","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090973166","display_name":"Alan Gilberto Ram\u00edrez Valverde","orcid":"https://orcid.org/0000-0002-9168-2072","observed_orcids":["https://orcid.org/0000-0002-9168-2072"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alan Gilberto Ram\u00edrez-Valverde","raw_affiliation_strings":["Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades \"Bernardo Sep\u00falveda\", Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, M\u00e9xico. mcruzl@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades \"Bernardo Sep\u00falveda\", Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, M\u00e9xico. mcruzl@yahoo.com","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004481405","display_name":"Diana Lizzete Ant\u00fanez-Ortiz","orcid":"https://orcid.org/0000-0003-0928-8357","observed_orcids":["https://orcid.org/0000-0003-0928-8357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Lizzete Ant\u00fanez-Ortiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049297015","display_name":"Alberto M\u00e9ndez-Beleche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto M\u00e9ndez-Beleche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053181178","display_name":"Eugenia Flores\u2010Alfaro","orcid":"https://orcid.org/0000-0002-0816-8874","observed_orcids":["https://orcid.org/0000-0002-0816-8874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugenia Flores-Alfaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079331782","display_name":"Iv\u00e1n de Jes\u00fas Ascencio-Montiel","orcid":"https://orcid.org/0000-0001-7034-0586","observed_orcids":["https://orcid.org/0000-0001-7034-0586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Jes\u00fas Ascencio-Montiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064103007","display_name":"Miguel Cruz","orcid":"https://orcid.org/0000-0001-9985-6172","observed_orcids":["https://orcid.org/0000-0001-9985-6172","https://orcid.org/0000-0003-4280-4501","https://orcid.org/0000-0001-6909-2941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1774,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52875407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"53","issue":"3","first_page":"348","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5249999761581421},{"id":"https://openalex.org/keywords/insulin-deficiency","display_name":"insulin deficiency","score":0.843999981880188},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.7566835880279541},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5861367583274841},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46006619930267334},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4373569190502167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42680075764656067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4218304455280304},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3734425902366638},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.35169368982315063},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.32723546028137207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27023112773895264},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.20343613624572754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15721213817596436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1404813528060913}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:25984620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25984620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica del Instituto Mexicano del Seguro Social","raw_type":"Journal Article"},{"id":"pmh:oai:redalyc.org:457744937016","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=457744937016","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista M\u00e9dica del Instituto Mexicano del Seguro Social (M\u00e9xico) Num.3 Vol.53","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:1667979288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25984620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1602867585","https://openalex.org/W1971321176","https://openalex.org/W1975066506","https://openalex.org/W1975813398","https://openalex.org/W1984251365","https://openalex.org/W1987931937","https://openalex.org/W1989626098","https://openalex.org/W2006136630","https://openalex.org/W2008891310","https://openalex.org/W2011684776","https://openalex.org/W2014606320","https://openalex.org/W2016599733","https://openalex.org/W2018414269","https://openalex.org/W2019037442","https://openalex.org/W2021513620","https://openalex.org/W2021714239","https://openalex.org/W2022343351","https://openalex.org/W2022905671","https://openalex.org/W2025835434","https://openalex.org/W2033756616","https://openalex.org/W2035321983","https://openalex.org/W2037412207","https://openalex.org/W2043277040","https://openalex.org/W2047213526","https://openalex.org/W2056447496","https://openalex.org/W2058805992","https://openalex.org/W2060114404","https://openalex.org/W2061015334","https://openalex.org/W2067897404","https://openalex.org/W2072374023","https://openalex.org/W2074548625","https://openalex.org/W2075690247","https://openalex.org/W2079808908","https://openalex.org/W2084708009","https://openalex.org/W2085755265","https://openalex.org/W2085861881","https://openalex.org/W2094174059","https://openalex.org/W2101230323","https://openalex.org/W2102865103","https://openalex.org/W2109754852","https://openalex.org/W2119402784","https://openalex.org/W2121184698","https://openalex.org/W2126100846","https://openalex.org/W2128847448","https://openalex.org/W2130542470","https://openalex.org/W2130553334","https://openalex.org/W2134646525","https://openalex.org/W2136333185","https://openalex.org/W2136938777","https://openalex.org/W2140570428","https://openalex.org/W2140659735","https://openalex.org/W2140906093","https://openalex.org/W2149129820","https://openalex.org/W2155707112","https://openalex.org/W2157205259","https://openalex.org/W2159379246","https://openalex.org/W2160435411","https://openalex.org/W2165194160","https://openalex.org/W7071999509"],"related_works":["https://openalex.org/W7062737367","https://openalex.org/W2235921384","https://openalex.org/W1989626098","https://openalex.org/W3087038676","https://openalex.org/W2805989743","https://openalex.org/W2772580011","https://openalex.org/W2790389644","https://openalex.org/W2245127420","https://openalex.org/W2122204563","https://openalex.org/W1980913460"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"(T2D)":[3],"is":[4,18,35,108,120],"a":[5,9],"disease":[6],"characterized":[7],"by":[8,101],"deficiency":[10],"in":[11,44],"production":[12],"or":[13],"action":[14],"of":[15,22,25,39,87,96,116,134,138],"insulin.":[16],"It":[17,34],"the":[19,23,26,40,45,51,88,93,114],"result":[20],"mainly":[21],"interaction":[24],"environment,":[27],"lifestyle,":[28],"as":[29,31,37,132],"well":[30],"genetic":[32,135],"factors.":[33],"considered":[36],"one":[38],"major":[41],"health":[42],"issues":[43],"world":[46],"because":[47],"it":[48,59],"affects":[49],"severely":[50],"psychological":[52],"well-being":[53],"and":[54,76,90,98],"overall":[55],"life":[56],"quality.":[57],"Recently":[58],"has":[60],"been":[61],"shown":[62],"that":[63,125],"DNA":[64],"copy":[65],"number":[66],"variations":[67,127],"(CNVs)":[68],"are":[69,80],"associated":[70],"with":[71],"several":[72],"diseases,":[73,118],"including":[74],"obesity":[75],"T2D.":[77,139],"The":[78],"CNVs":[79,137],"present":[81],"from":[82],"9":[83],"to":[84,113,122],"18":[85],"%":[86],"genome":[89],"can":[91,128],"modify":[92],"expression":[94],"levels":[95],"mRNA":[97],"proteins":[99],"encoded":[100],"genes":[102],"located":[103],"near":[104],"their":[105,111],"localization.":[106],"Less":[107],"known":[109],"about":[110],"contribution":[112],"pathogenesis":[115],"metabolic":[117],"which":[119],"necessary":[121],"characterize":[123],"so":[124],"these":[126],"be":[129],"potentially":[130],"used":[131],"biomarkers":[133],"risk":[136]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}