{"id":"https://openalex.org/W166767720","doi":null,"title":"Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1.","display_name":"Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W166767720","mag":"166767720","pmid":"https://pubmed.ncbi.nlm.nih.gov/19079688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2596337"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2596337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2596337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2596337","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101657878","display_name":"Shu Zhu","orcid":"https://orcid.org/0000-0003-2211-9646","observed_orcids":["https://orcid.org/0000-0003-2211-9646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318278","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-7941-7022","observed_orcids":["https://orcid.org/0000-0002-7941-7022","https://orcid.org/0000-0003-2679-4075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391343","display_name":"Jianhua Li","orcid":"https://orcid.org/0000-0001-5227-8627","observed_orcids":["https://orcid.org/0000-0001-5227-8627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianhua Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260091","display_name":"Andrew E. Sama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew E Sama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100452906","display_name":"Haichao Wang","orcid":"https://orcid.org/0000-0002-0211-9000","observed_orcids":["https://orcid.org/0000-0002-0211-9000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haichao Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7221,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84360406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"1","issue":"1","first_page":"64","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.305400013923645,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.859000027179718},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.6690000295639038},{"id":"https://openalex.org/keywords/angelica-sinensis","display_name":"Angelica sinensis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.9929999709129333},{"id":"https://openalex.org/keywords/camellia-sinensis","display_name":"Camellia sinensis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/extracellular-hmgb1","display_name":"extracellular HMGB1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7739999890327454},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.9001553058624268},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8393470048904419},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8296456933021545},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8238239288330078},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.6868352293968201},{"id":"https://openalex.org/C2776332195","wikidata":"https://www.wikidata.org/wiki/Q1000854","display_name":"Salvia miltiorrhiza","level":4,"score":0.6603792309761047},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5644281506538391},{"id":"https://openalex.org/C2909810673","wikidata":"https://www.wikidata.org/wiki/Q261503","display_name":"Chinese herbs","level":4,"score":0.5490539073944092},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45821139216423035},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.416240394115448},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36102038621902466},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.30168479681015015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08661356568336487},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2596337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2596337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:19079688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19079688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:166767720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19079688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2596337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2596337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4729744812","display_name":"Regulation of HMGB1 Release in Endotoxemia.","funder_award_id":"R01GM063075","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6397982580","display_name":"Neuroprotective Role of Fetuin in Cerebral Ischemia","funder_award_id":"R01GM070817","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W31174208","https://openalex.org/W182989442","https://openalex.org/W2413856090"],"related_works":["https://openalex.org/W1971988350","https://openalex.org/W2110057979","https://openalex.org/W1965764984","https://openalex.org/W2157863586","https://openalex.org/W1995368206","https://openalex.org/W1614633287","https://openalex.org/W2128556033","https://openalex.org/W2088155787","https://openalex.org/W1910775999","https://openalex.org/W2160369507"],"abstract_inverted_index":{"Sepsis":[0],"refers":[1],"to":[2,37],"a":[3,10,69,121,128],"systemic":[4],"inflammatory":[5,72],"response":[6],"syndrome":[7],"resulting":[8],"from":[9,101],"microbial":[11],"infection,":[12,57],"which":[13,34],"kills":[14],">":[15],"225,000":[16],"people":[17],"annually":[18],"in":[19,151],"the":[20,112],"U.S.":[21],"alone.":[22],"The":[23],"high":[24],"mortality":[25],"of":[26,60,76,111,131],"sepsis":[27,103],"is":[28],"partly":[29],"mediated":[30],"by":[31],"bacterial":[32],"endotoxin,":[33],"stimulates":[35],"macrophages/monocytes":[36],"sequentially":[38],"release":[39,84],"early":[40,50],"(e.g.,":[41,45,80],"TNF)":[42],"and":[43,94,134,142],"late":[44,129],"HMGB1)":[46,66],"pro-inflammatory":[47],"cytokines.":[48],"Although":[49],"proinflammatory":[51,62],"cytokines":[52],"may":[53,67],"be":[54],"protective":[55],"against":[56],"excessive":[58],"accumulation":[59],"late-acting":[61],"mediators":[63],"(such":[64],"as":[65,127,145],"sustain":[68],"potentially":[70],"injurious":[71],"response.":[73],"Agents":[74],"capable":[75],"inhibiting":[77],"HMGB1":[78,126],"activities":[79],"neutralizing":[81],"antibodies)":[82],"or":[83],"[e.g.,":[85],"Chinese":[86,138],"herbs,":[87],"Danggui":[88],"(Angelica":[89],"sinensis),":[90],"Danshen":[91,141],"(Salvia":[92],"miltiorrhiza)":[93],"Green":[95,143],"tea":[96],"(Camellia":[97],"sinensis)]":[98],"rescue":[99],"mice":[100],"lethal":[102,132],"even":[104],"when":[105],"given":[106],"24":[107],"hours":[108],"after":[109],"onset":[110],"disease.":[113],"Here":[114],"we":[115],"review":[116],"emerging":[117],"evidence":[118],"that":[119],"support":[120],"critical":[122],"role":[123],"for":[124],"extracellular":[125],"mediator":[130],"sepsis,":[133],"several":[135],"commonly":[136],"used":[137],"herbs":[139],"(Danggui,":[140],"tea)":[144],"potential":[146],"HMGB1-":[147],"targeting":[148],"therapeutic":[149],"agents":[150],"experimental":[152],"sepsis.":[153]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
