{"id":"https://openalex.org/W166643326","doi":null,"title":"Arginine transport and nitric oxide production: role in the inflammatory response","display_name":"Arginine transport and nitric oxide production: role in the inflammatory response","publication_year":2008,"publication_date":"2008-03-04","ids":{"openalex":"https://openalex.org/W166643326","mag":"166643326"},"language":"en","primary_location":{"id":"pmh:oai:dspace-unipr.cineca.it:1889/778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/778","pdf_url":"https://air.unipr.it/bitstream/1889/778/1/PhD%20thesis.pdf","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://air.unipr.it/bitstream/1889/778/1/PhD%20thesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006771592","display_name":"Amelia Barilli","orcid":"https://orcid.org/0000-0002-2256-0530","observed_orcids":["https://orcid.org/0000-0002-2256-0530"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Barilli, Amelia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006771592"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arginine-transport","display_name":"arginine transport","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9229999780654907},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8650000095367432},{"id":"https://openalex.org/keywords/system-y","display_name":"system y+","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cationic-amino-acid-transporters","display_name":"cationic amino acid transporters","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6890000104904175},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.6970000267028809},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.7639999985694885},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8069999814033508},{"id":"https://openalex.org/keywords/blood-monocytes","display_name":"blood monocytes","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8515374660491943},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.6251600980758667},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.47236138582229614},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.4542849063873291},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37861931324005127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35195598006248474},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3025937080383301},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22375398874282837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22296357154846191},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20992788672447205},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.07827714085578918},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dspace-unipr.cineca.it:1889/778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/778","pdf_url":"https://air.unipr.it/bitstream/1889/778/1/PhD%20thesis.pdf","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:dspace-unipr.cineca.it:1889/778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/778","pdf_url":"https://air.unipr.it/bitstream/1889/778/1/PhD%20thesis.pdf","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W166643326.pdf","grobid_xml":"https://content.openalex.org/works/W166643326.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W40877440","https://openalex.org/W75614840","https://openalex.org/W83772984","https://openalex.org/W1481797092","https://openalex.org/W1487676457","https://openalex.org/W1540095279","https://openalex.org/W1560301770","https://openalex.org/W1594742256","https://openalex.org/W1617532721","https://openalex.org/W1805538867","https://openalex.org/W1923194856","https://openalex.org/W1927805387","https://openalex.org/W1968537876","https://openalex.org/W1969545692","https://openalex.org/W1969703987","https://openalex.org/W1971428935","https://openalex.org/W1974941957","https://openalex.org/W1978504014","https://openalex.org/W1980528903","https://openalex.org/W1983020442","https://openalex.org/W1983698019","https://openalex.org/W1984870795","https://openalex.org/W1992935306","https://openalex.org/W1994436693","https://openalex.org/W1994554366","https://openalex.org/W1996096481","https://openalex.org/W1997472169","https://openalex.org/W2000731858","https://openalex.org/W2001259221","https://openalex.org/W2003389414","https://openalex.org/W2004343006","https://openalex.org/W2007737411","https://openalex.org/W2009013636","https://openalex.org/W2011007912","https://openalex.org/W2011485783","https://openalex.org/W2012156608","https://openalex.org/W2016293419","https://openalex.org/W2021483365","https://openalex.org/W2021959636","https://openalex.org/W2022719473","https://openalex.org/W2023404740","https://openalex.org/W2026663790","https://openalex.org/W2026707952","https://openalex.org/W2029491963","https://openalex.org/W2032200371","https://openalex.org/W2032350328","https://openalex.org/W2033601159","https://openalex.org/W2033996868","https://openalex.org/W2035088045","https://openalex.org/W2038689279","https://openalex.org/W2039949381","https://openalex.org/W2040319474","https://openalex.org/W2041075406","https://openalex.org/W2042695353","https://openalex.org/W2042782418","https://openalex.org/W2049288643","https://openalex.org/W2054949240","https://openalex.org/W2056440800","https://openalex.org/W2061880513","https://openalex.org/W2063936994","https://openalex.org/W2064554088","https://openalex.org/W2070431647","https://openalex.org/W2074355024","https://openalex.org/W2082207249","https://openalex.org/W2082748378","https://openalex.org/W2083285004","https://openalex.org/W2095104103","https://openalex.org/W2101138552","https://openalex.org/W2101535451","https://openalex.org/W2102052199","https://openalex.org/W2116999983","https://openalex.org/W2119470649","https://openalex.org/W2121203285","https://openalex.org/W2121710221","https://openalex.org/W2122289183","https://openalex.org/W2134138119","https://openalex.org/W2136414832","https://openalex.org/W2143146123","https://openalex.org/W2145642904","https://openalex.org/W2156365086","https://openalex.org/W2157603347","https://openalex.org/W2159157497","https://openalex.org/W2159400209","https://openalex.org/W2160079255","https://openalex.org/W2162572785","https://openalex.org/W2169417490","https://openalex.org/W2172296189","https://openalex.org/W2187350285","https://openalex.org/W2285905111","https://openalex.org/W2400778383","https://openalex.org/W2408805118","https://openalex.org/W2419030918","https://openalex.org/W2419604885","https://openalex.org/W2424047003","https://openalex.org/W2474896145","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2107541275","https://openalex.org/W2101535451","https://openalex.org/W7099044761","https://openalex.org/W2027388172","https://openalex.org/W1970179727","https://openalex.org/W2160302014","https://openalex.org/W1212704","https://openalex.org/W2035177724","https://openalex.org/W1501833360","https://openalex.org/W1979523778"],"abstract_inverted_index":{"The":[0,175],"research":[1],"concerns":[2],"the":[3,6,10,14,32,51,76,88,95,115,119,127,133,162,170],"characterization":[4],"of":[5,12,70,78,90,97,108,118,126,135,164,172,178],"pathways":[7],"responsible":[8],"for":[9,17,42,192],"recruitment":[11],"L-arginine,":[13],"obliged":[15],"substrate":[16],"nitric":[18],"oxide":[19],"biosynthesis,":[20],"in":[21,50,62,86,122,132,147,159,169,197],"human":[22,43,128,193],"cells.":[23],"Endothelial":[24],"cells":[25,125],"and":[26,56,74,92,100,111,181],"monocytes/macrophages":[27],"have":[28,140],"been":[29],"employed,":[30],"as":[31],"cell":[33,109],"types":[34],"more":[35],"directly":[36],"linked":[37],"to":[38,66,75,155],"NO":[39,165,182],"pathway.":[40],"As":[41],"endothelium,":[44],"only":[45],"system":[46,144],"y+":[47],"is":[48,166],"involved":[49],"inflammatory":[52,156,173,185],"response:":[53],"both":[54,82],"TNF\u03b1":[55],"rapamycin,":[57],"an":[58],"mTOR":[59],"inhibitor":[60],"employed":[61],"clinical":[63],"angioplasty,":[64],"lead":[65],"a":[67,105],"massive":[68],"increase":[69],"CAT-mediated":[71],"arginine":[72,136,179],"influx":[73],"activation":[77],"endothelial":[79],"cells;":[80],"however,":[81],"compounds":[83],"are":[84,153],"ineffective":[85],"stimulating":[87],"synthesis":[89],"NO,":[91],"even":[93,168],"diminish":[94],"expression":[96],"eNOS":[98],"mRNA":[99],"protein.":[101],"Rapamycin":[102],"also":[103,158],"causes":[104],"significant":[106],"loss":[107],"viability":[110],"function,":[112],"thus":[113,188],"confirming":[114],"adverse":[116],"effects":[117],"drug":[120],"observed":[121],"vivo.":[123],"Among":[124],"monocyte/macrophage":[129],"lineage,":[130],"differences":[131],"modulation":[134],"transport":[137,180],"by":[138],"cytokines":[139],"emerged:":[141],"IFN\u03b3":[142],"stimulates":[143],"y+L":[145],"activity":[146],"blood":[148],"monocytes,":[149],"while":[150],"alveolar":[151],"macrophages":[152],"insensitive":[154],"stimuli;":[157],"these":[160],"models,":[161],"production":[163],"undetectable":[167],"presence":[171],"cytokines.":[174],"supposed":[176],"co-induction":[177],"biosynthesis":[183],"under":[184],"conditions":[186],"may":[187],"not":[189],"be":[190],"valid":[191],"cells,":[194],"although":[195],"plausible":[196],"animal":[198],"models.":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}