{"id":"https://openalex.org/W1664844693","doi":"https://doi.org/10.1111/j.1398-9995.2008.01668.x","title":"A 12\u2010week placebo\u2010controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis","display_name":"A 12\u2010week placebo\u2010controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis","publication_year":2008,"publication_date":"2008-06-13","ids":{"openalex":"https://openalex.org/W1664844693","doi":"https://doi.org/10.1111/j.1398-9995.2008.01668.x","mag":"1664844693","pmid":"https://pubmed.ncbi.nlm.nih.gov/18588560"},"language":"en","primary_location":{"id":"doi:10.1111/j.1398-9995.2008.01668.x","doi":"https://doi.org/10.1111/j.1398-9995.2008.01668.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.2008.01668.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005383086","display_name":"Sara Fantin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Fantin","raw_affiliation_strings":["Hospital Presidente Per\u00f3n, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Presidente Per\u00f3n, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025719019","display_name":"Jorge Fernando Maspero","orcid":"https://orcid.org/0000-0001-9750-2346","observed_orcids":["https://orcid.org/0000-0001-9750-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Maspero","raw_affiliation_strings":["CIDEA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIDEA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Bisbal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118543","display_name":"Hospital Regional Rancagua","ror":"https://ror.org/02f3rn888","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210118543"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"C. Bisbal","raw_affiliation_strings":["Hospital Regional Rancagua, Santiago de Chile, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Regional Rancagua, Santiago de Chile, Chile","institution_ids":["https://openalex.org/I4210118543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030244193","display_name":"Ioana Octavia Agache","orcid":"https://orcid.org/0000-0001-7994-364X","observed_orcids":["https://orcid.org/0000-0001-7994-364X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Agache","raw_affiliation_strings":["SC Radoi Mariana SRL Brasov, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Radoi Mariana SRL Brasov, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736040","display_name":"Esther Donado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154262","display_name":"Uriach (Spain)","ror":"https://ror.org/04jfxq686","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210154262"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Donado","raw_affiliation_strings":["J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]},{"raw_affiliation_string":"J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127315","display_name":"Javier Borja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154262","display_name":"Uriach (Spain)","ror":"https://ror.org/04jfxq686","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210154262"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Borja","raw_affiliation_strings":["J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]},{"raw_affiliation_string":"J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019199417","display_name":"O. Mol\u00e0","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154262","display_name":"Uriach (Spain)","ror":"https://ror.org/04jfxq686","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210154262"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"O. Mola","raw_affiliation_strings":["J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]},{"raw_affiliation_string":"J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039447483","display_name":"I\u00f1aki Izquierdo","orcid":"https://orcid.org/0000-0002-6963-6061","observed_orcids":["https://orcid.org/0000-0002-6963-6061"]},"institutions":[{"id":"https://openalex.org/I4210154262","display_name":"Uriach (Spain)","ror":"https://ror.org/04jfxq686","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210154262"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"I. Izquierdo","raw_affiliation_strings":["J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Uriach y Compan\u0303i\u0301a, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]},{"raw_affiliation_string":"J. Uriach y Compa\u00f1\u00eda, S.A., Clinical Development Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210154262"]}]},{"author_position":"last","author":{"id":null,"display_name":"on behalf of international Rupatadine study group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"on behalf of international Rupatadine study group","raw_affiliation_strings":["see Appendix"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"see Appendix","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039447483"],"corresponding_institution_ids":["https://openalex.org/I4210154262"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":4.474,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94809103,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"63","issue":"7","first_page":"924","last_page":"931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rupatadine","display_name":"rupatadine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cetirizine","display_name":"cetirizine","score":1.0},{"id":"https://openalex.org/keywords/persistent-allergic-rhinitis","display_name":"persistent allergic rhinitis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/histamine-h1-receptor-antagonists","display_name":"histamine H1 receptor antagonists","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nasal-symptoms","display_name":"nasal symptoms","score":0.46700000762939453},{"id":"https://openalex.org/keywords/nasal-obstruction","display_name":"nasal obstruction","score":0.7590000033378601},{"id":"https://openalex.org/keywords/symptom-scores","display_name":"symptom scores","score":0.6359999775886536},{"id":"https://openalex.org/keywords/onset-of-action","display_name":"onset of action","score":0.9639999866485596},{"id":"https://openalex.org/keywords/long-term-treatment-efficacy","display_name":"long-term treatment efficacy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2779463773","wikidata":"https://www.wikidata.org/wiki/Q423075","display_name":"Cetirizine","level":2,"score":0.9251981973648071},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8414486646652222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8233332633972168},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.523101806640625},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5229780673980713},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4777740240097046},{"id":"https://openalex.org/C46821324","wikidata":"https://www.wikidata.org/wiki/Q7094540","display_name":"Onset of action","level":2,"score":0.4765658676624298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41323596239089966},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09096351265907288},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017332","descriptor_name":"Cetirizine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017332","descriptor_name":"Cetirizine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017332","descriptor_name":"Cetirizine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1398-9995.2008.01668.x","doi":"https://doi.org/10.1111/j.1398-9995.2008.01668.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.2008.01668.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:18588560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18588560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W33737902","https://openalex.org/W128209363","https://openalex.org/W1930304642","https://openalex.org/W1987932439","https://openalex.org/W1997294419","https://openalex.org/W2015656958","https://openalex.org/W2017415976","https://openalex.org/W2025004664","https://openalex.org/W2059332672","https://openalex.org/W2075154135","https://openalex.org/W2077165356","https://openalex.org/W2094693214","https://openalex.org/W2095539083","https://openalex.org/W2096210343","https://openalex.org/W2104772877","https://openalex.org/W2155701010","https://openalex.org/W2157801190","https://openalex.org/W2167446184","https://openalex.org/W2185530710","https://openalex.org/W2395244951"],"related_works":["https://openalex.org/W2137991095","https://openalex.org/W2028773433","https://openalex.org/W1994599708","https://openalex.org/W2957788004","https://openalex.org/W2029910677","https://openalex.org/W7096576330","https://openalex.org/W3017992510","https://openalex.org/W2590197432","https://openalex.org/W128209363","https://openalex.org/W2138994012"],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"the":[2,49,105,113,120,165,184],"current":[3],"increasing":[4],"incidence":[5],"of":[6,44,51,56,99,119,179,233,246,252,262],"allergies":[7],"worldwide,":[8],"new":[9],"treatments":[10,190,237],"showing":[11],"efficacy":[12,50,110],"and":[13,96,148,172,254],"long":[14,260],"term":[15],"safety":[16],"are":[17],"needed":[18],"for":[19,188],"chronic":[20],"conditions":[21],"such":[22],"as":[23,102],"persistent":[24],"allergic":[25],"rhinitis":[26],"(PER).":[27],"New":[28],"generation":[29],"H1-antihistamines":[30],"have":[31],"demonstrated":[32],"anti-allergic":[33],"properties,":[34],"which":[35],"could":[36],"possibly":[37],"enhance":[38],"their":[39],"effectiveness":[40],"in":[41,53,73,136,225],"long-term":[42],"periods":[43],"treatment.":[45],"OBJECTIVE:":[46],"To":[47],"investigate":[48],"rupatadine,":[52],"controlling":[54],"symptoms":[55,207,245],"PER":[57,100],"over":[58,258],"a":[59,218,249,259],"12-week":[60,114],"period.":[61],"METHODS:":[62],"A":[63],"randomized,":[64],"double":[65],"blind,":[66],"parallel-group,":[67],"placebo-controlled":[68],"study":[69],"was":[70,112,181],"carried":[71],"out":[72],"patients":[74,127],"aged":[75],"older":[76],"than":[77],"12":[78,176,234],"years":[79],"with":[80,221,227],"PER.":[81],"Main":[82],"inclusion":[83],"criteria":[84],"were:":[85],"instantaneous":[86,204],"total":[87,205],"symptom":[88],"score":[89,94,208],"(i6TSS)":[90],">or=45,":[91],"nasal":[92,206,211],"obstruction":[93],"<or=12,":[95],"overall":[97],"assessment":[98],">or=2":[101],"moderate":[103],"during":[104],"first":[106,185],"visit.":[107],"The":[108],"primary":[109],"endpoint":[111],"average":[115],"change":[116,214],"from":[117,215],"baseline":[118,166,216],"patients'":[121],"i6TSS.":[122],"RESULTS:":[123],"In":[124],"all,":[125],"736":[126],"were":[128,134,238],"selected.":[129],"Of":[130],"them,":[131],"543":[132],"(73.8%)":[133],"randomized":[135],"three":[137],"different":[138],"groups:":[139],"placebo":[140,169],"(n":[141,145,150],"=":[142,146,151,155,161,195,201],"185),":[143],"cetirizine":[144,159,197],"175)":[147],"rupatadine":[149,222],"183).":[152],"Rupatadine":[153,242],"(P":[154,160],"0.008)":[156],"but":[157],"not":[158],"0.07)":[162],"statistically":[163],"reduced":[164],"i6TSS":[167],"vs":[168,192,198],"(47.8%,":[170],"44.7%":[171],"38.8%,":[173],"respectively),":[174],"after":[175],"weeks.":[177,235],"Onset":[178],"action":[180,253],"observed":[182],"at":[183],"24":[186],"h":[187],"both":[189],"(rupatadine":[191],"placebo,":[193,199,228],"P":[194,200],"0.013;":[196],"0.015).":[202],"Furthermore,":[203],"(iTNSS)":[209],"(including":[210],"blockage)":[212],"mean":[213],"showed":[217],"significant":[219],"reduction":[220],"10":[223],"mg":[224],"comparison":[226],"along":[229],"all":[230],"treatment":[231],"duration":[232],"Study":[236],"well":[239],"tolerated.":[240],"CONCLUSION:":[241],"significantly":[243],"relieves":[244],"PER,":[247],"providing":[248],"rapid":[250],"onset":[251],"maintains":[255],"its":[256],"effects":[257],"period":[261],"12-weeks.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}